Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
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•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
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•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
•
•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
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Publication |
First Author: |
Miyazaki M |
Year: |
2009 |
Journal: |
Biochem Biophys Res Commun |
Title: |
DOC2b is a SNARE regulator of glucose-stimulated delayed insulin secretion. |
Volume: |
384 |
Issue: |
4 |
Pages: |
461-5 |
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•
•
•
•
•
|
Allele |
Name: |
double C2, beta; endonuclease-mediated mutation 1, Channabasavaiah Gurumurthy |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Inducible, Recombinase |
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•
•
•
•
•
|
Publication |
First Author: |
Yao J |
Year: |
2011 |
Journal: |
Cell |
Title: |
Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release. |
Volume: |
147 |
Issue: |
3 |
Pages: |
666-77 |
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•
•
•
•
•
|
Publication |
First Author: |
Sato M |
Year: |
2010 |
Journal: |
J Neurochem |
Title: |
Role of the polybasic sequence in the Doc2alpha C2B domain in dense-core vesicle exocytosis in PC12 cells. |
Volume: |
114 |
Issue: |
1 |
Pages: |
171-81 |
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•
•
•
•
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Protein Domain |
Type: |
Family |
Description: |
Doc2a (double C2-like domain-containing protein alpha) and Doc2b (double C2-like domain-containing protein beta) are members of the double C2 domain protein family. Doc2a is expressed in neuronal cells and has been implicated in Ca2+-dependent neurotransmitter release [, ]. Doc2a exhibits Ca2+-dependent phospholipid-binding activity through its C2A domain, which is thought to be important for the regulation of Ca2+-dependent exocytosis. The C2B domain is required for binding of syntaxin-1a/synaptosome-associated protein of 25kDa (SNAP-25) heterodimer []. Doc2a is also expressed in pancreatic islets, and has been implicated together with Doc2b in the synergistic regulation of glucose-stimulated insulin secretion [].Doc2b contains two calcium and phospholipid binding domains in its C terminus []. It interacts with the SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) complex composed of SNAP25, STX1A and VAMP2. Doc2b regulates SNARE-dependent fusion of vesicles with membranes in a calcium-dependent manner. It is involved in calcium-dependent spontaneous release of neurotransmitter, with a function analogous to synaptotagmin-1, but with a higher Ca2+ sensitivity []. Doc2b is a positive SNARE regulator for glucose transporter GLUT4 vesicle fusion and mediates insulin-stimulated glucose transport in adipocytes []. It is involved in both insulin-stimulated glucose uptake in adipocytes and glucose-stimulated insulin secretion in pancreatic cells, as well as insulin responsiveness in skeletal muscle [, ]. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
83
|
Fragment?: |
true |
|
•
•
•
•
•
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Genotype |
Symbol: |
Doc2b/Doc2b<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> |
Background: |
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl |
Zygosity: |
cn |
Has Mutant Allele: |
true |
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•
•
•
•
•
|
Publication |
First Author: |
Fukuda M |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
The C2A domain of double C2 protein gamma contains a functional nuclear localization signal. |
Volume: |
276 |
Issue: |
27 |
Pages: |
24441-4 |
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•
•
•
•
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Protein Domain |
Type: |
Family |
Description: |
This entry represents double C2-like domain-containing protein gamma (Doc2g). The Doc2 (double C2) family members Doc2a and Doc2b are characterised by an N-terminal Munc13-1 interacting domain, and two C2 domains that interact with Ca(2+) and phospholipid at the C terminus. In contrast, the C2 domains of Doc2g impair Ca(2+)-dependent phospholipid binding activity. The Ca2+-independent C2A domain of Doc2g seems to have a nuclear localisation function []. Doc2g may also function as an effector for Munc13-1, and it may be involved in the regulation of vesicular trafficking []. |
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Publication |
First Author: |
Verhage M |
Year: |
1997 |
Journal: |
Neuron |
Title: |
DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion. |
Volume: |
18 |
Issue: |
3 |
Pages: |
453-61 |
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•
•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
133
|
Fragment?: |
true |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
405
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
412
|
Fragment?: |
false |
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•
•
•
•
•
|
Publication |
First Author: |
Fukuda M |
Year: |
2000 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Doc2gamma, a third isoform of double C2 protein, lacking calcium-dependent phospholipid binding activity. |
Volume: |
276 |
Issue: |
2 |
Pages: |
626-32 |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
211
|
Fragment?: |
true |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
262
|
Fragment?: |
true |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
405
|
Fragment?: |
true |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
177
|
Fragment?: |
true |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
196
|
Fragment?: |
true |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
387
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
387
|
Fragment?: |
false |
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•
•
•
•
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