Splicing by the spliceosome involves branching and exon ligation. The branching reaction leads to the formation of the catalytic step I spliceosome (C complex). This entry includes budding yeast Yuj2 and its human homologue, CCDC94. They are part of the C complex []. Yju2 is a splicing factor associated with the Prp19-associated complex and acts after Prp2 in promoting the first catalytic reaction of pre-mRNA splicing [].
This entry includes Probable splicing factor YJU2B (also known as CCDC130) and Splicing factor YJU2 (also known as CCDC94) from humans, Saf4 from fission yeasts and Yju2 from budding yeasts. Saf4 (also known as cwc16) is involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome []. Yju2 is a splicing factor that is associated with the Prp19-associated complex and acts after Prp2 in promoting the first catalytic reaction of pre-mRNA splicing. It may play a role in stabilizing the structure of the spliceosome catalytic core [, ].
