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Search results 501 to 559 out of 559 for Npc1

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0.036s

Type

Details

Score

Allele

Npc1<em1Smoc> | MGI:7291362

Name:	NPC intracellular cholesterol transporter 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type:	Endonuclease-mediated
Attribute String:	Not Specified

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Strain

MGI:6770996 | C57BL/6J-Npc1<em2Smoc>/Smoc

Attribute String:

coisogenic, endonuclease-mediated mutation, mutant strain

•

Strain

MGI:6355074 | C57BL/6J-Npc1<em1(I1060T)Smoc>/Smoc

Attribute String:

coisogenic, mutant strain, endonuclease-mediated mutation

•

Allele

Tg(Npc1-EGFP)KB67Gsat | MGI:4847267

Name:	transgene insertion KB67, GENSAT Project at Rockefeller University
Allele Type:	Transgenic
Attribute String:	Reporter

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Publication

18356535 | J:136627

First Author:	de Vogel-van den Bosch HM
Year:	2008
Journal:	Am J Physiol Gastrointest Liver Physiol
Title:	A cholesterol-free, high-fat diet suppresses gene expression of cholesterol transporters in murine small intestine.
Volume:	294
Issue:	5
Pages:	G1171-80

•

Allele

Tg(APOE-NPC1L1)20Lqyu | MGI:3799059

Name:	transgene insertion 20, Liqing Yu
Allele Type:	Transgenic
Attribute String:	Humanized sequence, Inserted expressed sequence

•

Strain

MGI:5655927 | B6;D2-Tg(APOE-NPC1L1)20Lqyu/J

Attribute String:

mutant stock, transgenic

•

Publication

25600868 | J:222809

First Author:	Warrier M
Year:	2015
Journal:	Cell Rep
Title:	The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance.

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Publication

32123832 | J:283890

First Author:	Toyoda Y
Year:	2019
Journal:	FASEB Bioadv
Title:	Identification of hepatic NPC1L1 as an NAFLD risk factor evidenced by ezetimibe-mediated steatosis prevention and recovery.
Volume:	1
Issue:	5
Pages:	283-295

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Strain

MGI:6315235 | B6.Cg-Npc1<tm1Tacf>/J

Attribute String:

congenic, mutant strain, targeted mutation

•

Strain

MGI:6359476 | B6(Cg)-Npc1<tm1Tacf>

Attribute String:

mutant strain, targeted mutation

•

Allele

Npc1<nmf164> | MGI:2686741

Name:	NPC intracellular cholesterol transporter 1; neuroscience mutagenesis facility, 164
Allele Type:	Chemically induced (ENU)
Attribute String:	Hypomorph

•

Allele

Npc1<tm2Tacf> | MGI:6315236

Name:	NPC intracellular cholesterol transporter 1; targeted mutation 2, The Addi and Cassi Fund
Allele Type:	Targeted
Attribute String:	Humanized sequence

•

Strain

MGI:5004056 | STOCK Tg(Npc1-EGFP)KB67Gsat/Mmucd

Attribute String:

mutant stock, transgenic

•

Allele

Tg(APOE-NPC1L1)112Lqyu | MGI:4822042

Name:	transgene insertion 112, Liqing Yu
Allele Type:	Transgenic
Attribute String:	Inserted expressed sequence

•

Genotype

Symbol:	Tg(APOE-NPC1L1)20Lqyu/?
Background:	involves: C57BL/6 * DBA/2
Zygosity:	ot
Has Mutant Allele:	true

•

Protein

Q3U2B2

Organism:	Mus musculus/domesticus
Length:	1094
Fragment?:	false

•

HT Experiment

E-GEOD-5944 | Transcription profiling of mouse BALB/c Npc1-/- and Npc1+/+ mutant cerebellum

Series Id:	GSE5944
Experiment Type:	transcription profiling by array
Study Type:	WT vs. Mutant
Source:	ArrayExpress

•

Strain

MGI:6315237 | B6.Cg-Npc1<tm2Tacf>/J

Attribute String:

targeted mutation, congenic, mutant strain

•

Strain

MGI:6359478 | B6(Cg)-Npc1<tm2Tacf>

Attribute String:

mutant strain, targeted mutation

•

Genotype

Symbol:	Npc1/Npc1
Background:	B6(Cg)-Npc1
Zygosity:	hm
Has Mutant Allele:	true

•

Strain

MGI:2674921 | C57BL/6J-Npc1<nmf164>/J

Attribute String:

mutant strain, coisogenic, chemically induced mutation

•

Genotype

Symbol:	Npc1/Npc1
Background:	C57BL/6J-Npc1/J
Zygosity:	hm
Has Mutant Allele:	true

•

HT Experiment

E-GEOD-20450 | Microarray analysis in Npc1-/- mouse cerebellum

Series Id:	GSE20450
Experiment Type:	transcription profiling by array
Study Type:	WT vs. Mutant
Source:	ArrayExpress

•

Protein

Q6T3U4

Organism:	Mus musculus/domesticus
Length:	1333
Fragment?:	false

•

Protein

O35604

Organism:	Mus musculus/domesticus
Length:	1277
Fragment?:	false

•

Protein

A3KMG9

Organism:	Mus musculus/domesticus
Length:	1332
Fragment?:	true

•

Protein

Z4YJC9

Organism:	Mus musculus/domesticus
Length:	1333
Fragment?:	false

•

Protein

Q7TMD4

Organism:	Mus musculus/domesticus
Length:	1277
Fragment?:	false

•

Publication

17571164 | J:124193

First Author:	Temel RE
Year:	2007
Journal:	J Clin Invest
Title:	Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe.
Volume:	117
Issue:	7
Pages:	1968-78

•

Publication

20620999 | J:163160

First Author:	Temel RE
Year:	2010
Journal:	Cell Metab
Title:	Biliary sterol secretion is not required for macrophage reverse cholesterol transport.
Volume:	12
Issue:	1
Pages:	96-102

•

Strain

MGI:6359480 | B6(Cg)-Npc1<tm1Tacf> Npc1<tm2Tacf>

Attribute String:

targeted mutation, mutant strain

•

Publication

9211849 | J:41464

First Author:	Carstea ED
Year:	1997
Journal:	Science
Title:	Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis.
Volume:	277
Issue:	5323
Pages:	228-31

•

Publication

28658628 | J:254706

First Author:	Wei J
Year:	2017
Journal:	Cell Rep
Title:	The GARP Complex Is Involved in Intracellular Cholesterol Transport via Targeting NPC2 to Lysosomes.
Volume:	19
Issue:	13
Pages:	2823-2835

•

Publication

18815434 | J:149006

First Author:	Rimkunas VM
Year:	2009
Journal:	J Lipid Res
Title:	TNF-{alpha} plays a role in hepatocyte apoptosis in Niemann-Pick type C liver disease.
Volume:	50
Issue:	2
Pages:	327-33

•

Publication

20416299 | J:161331

First Author:	Peake KB
Year:	2010
Journal:	FEBS Lett
Title:	Defective cholesterol trafficking in Niemann-Pick C-deficient cells.
Volume:	584
Issue:	13
Pages:	2731-9

•

Publication

23992240 | J:216714

First Author:	Maceyka M
Year:	2013
Journal:	FEBS J
Title:	The potential of histone deacetylase inhibitors in Niemann - Pick type C disease.
Volume:	280
Issue:	24
Pages:	6367-72

•

Publication

26784526 | J:229976

First Author:	Bosch M
Year:	2016
Journal:	Am J Pathol
Title:	Hepatic Primary and Secondary Cholesterol Deposition and Damage in Niemann-Pick Disease.
Volume:	186
Issue:	3
Pages:	517-23

•

Publication

29601818 | J:270602

First Author:	Wang Y
Year:	2018
Journal:	Biochem Biophys Res Commun
Title:	Hepatic NPC1L1 promotes hyperlipidemia in LDL receptor deficient mice.
Volume:	499
Issue:	3
Pages:	626-633

•

Publication

15121881 | J:92521

First Author:	Eskelinen EL
Year:	2004
Journal:	Mol Biol Cell
Title:	Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double-deficient fibroblasts.
Volume:	15
Issue:	7
Pages:	3132-45

•

Publication

21569847 | J:173243

First Author:	Belarbi K
Year:	2011
Journal:	Neurobiol Dis
Title:	Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology.
Volume:	43
Issue:	2
Pages:	486-94

•

Publication

18948618 | J:155275

First Author:	Liu W
Year:	2008
Journal:	Circ Res
Title:	Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance.
Volume:	103
Issue:	11
Pages:	1280-8

•

Publication

34183444 | J:338781

First Author:	Guix FX
Year:	2021
Journal:	Life Sci Alliance
Title:	Increased exosome secretion in neurons aging in vitro by NPC1-mediated endosomal cholesterol buildup.
Volume:	4
Issue:	8

•

Publication

36861884 | J:336775

First Author:	Sterling FR
Year:	2023
Journal:	J Cell Sci
Title:	StARD9 is a novel lysosomal kinesin required for membrane tubulation, cholesterol transport and Purkinje cell survival.
Volume:	136
Issue:	5

•

Publication

14963026 | J:89362

First Author:	Kishida T
Year:	2004
Journal:	J Biol Chem
Title:	Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism.
Volume:	279
Issue:	18
Pages:	19276-85

•

Publication

32107002 | J:292259

First Author:	Chatterjee S
Year:	2020
Journal:	Biochem Biophys Res Commun
Title:	Management of metabolic syndrome and reduction in body weight in type II diabetic mice by inhibiting glycosphingolipid synthesis.
Volume:	525
Issue:	2
Pages:	455-461

•

Publication

15666818 | J:97494

First Author:	Mellon S
Year:	2004
Journal:	Endocr Res
Title:	Niemann pick type C disease as a model for defects in neurosteroidogenesis.
Volume:	30
Issue:	4
Pages:	727-35

•

Publication

16141411 | J:154834

First Author:	Rigamonti E
Year:	2005
Journal:	Circ Res
Title:	Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages.
Volume:	97
Issue:	7
Pages:	682-9

•

Publication

24487591 | J:209427

First Author:	te Vruchte D
Year:	2014
Journal:	J Clin Invest
Title:	Relative acidic compartment volume as a lysosomal storage disorder-associated biomarker.
Volume:	124
Issue:	3
Pages:	1320-8

•

Publication

30166346 | J:270265

First Author:	Fleet AJ
Year:	2018
Journal:	J Biol Chem
Title:	The protein-specific activities of the transmembrane modules of Ptch1 and Ptch2 are determined by their adjacent protein domains.
Volume:	293
Issue:	43
Pages:	16583-16595

•

Publication

32244854 | J:301188

First Author:	Klein AD
Year:	2020
Journal:	Int J Mol Sci
Title:	Complement Component C3 Participates in Early Stages of Niemann-Pick C Mouse Liver Damage.
Volume:	21
Issue:	6

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Publication

35095535 | J:319739

First Author:	Du J
Year:	2021
Journal:	Front Pharmacol
Title:	The Effects of Combined Therapy With Metformin and Hydroxypropyl-β-Cyclodextrin in a Mouse Model of Niemann-Pick Disease Type C1.
Volume:	12

Pages:	825425

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Publication

37890669 | J:344360

First Author:	Zhao N
Year:	2023
Journal:	J Lipid Res
Title:	TMEM241 is a UDP-N-acetylglucosamine transporter required for M6P modification of NPC2 and cholesterol transport.
Volume:	64
Issue:	12
Pages:	100465

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Publication

31641049 | J:282353

First Author:	Lei M
Year:	2019
Journal:	J Neurosci
Title:	Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease.
Volume:	39
Issue:	48
Pages:	9645-9659

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Publication

22179027 | J:185098

First Author:	Boadu E
Year:	2012
Journal:	Biochim Biophys Acta
Title:	ABCA1-dependent mobilization of lysosomal cholesterol requires functional Niemann-Pick C2 but not Niemann-Pick C1 protein.
Volume:	1821
Issue:	3
Pages:	396-404

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Publication

- | J:94790

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Mouse Synonym Curation

•

Publication

- | J:84900

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2003
Journal:	Database Download
Title:	Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database

•

Publication

- | J:57747

First Author:	MGI Genome Annotation Group and UniGene Staff
Year:	2015
Journal:	Database Download
Title:	MGI-UniGene Interconnection Effort

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Publication

- | J:100256

First Author:	The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year:	2005
Journal:	Database Download
Title:	MGI download of GENSAT transgene data

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