Search our database by keyword

Examples

Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 501 to 531 out of 531 for Ung

<< First < Previous | Next > Last >>

0.019s

Type

Details

Score

Publication

34344536 | J:322019

First Author:	Boitnott A
Year:	2021
Journal:	Biol Psychiatry
Title:	Developmental and Behavioral Phenotypes in a Mouse Model of DDX3X Syndrome.
Volume:	90
Issue:	11
Pages:	742-755

•

Publication

33417013 | J:316220

First Author:	Jeanne M
Year:	2021
Journal:	Hum Genet
Title:	Haploinsufficiency of the HIRA gene located in the 22q11 deletion syndrome region is associated with abnormal neurodevelopment and impaired dendritic outgrowth.
Volume:	140
Issue:	6
Pages:	885-896

•

Publication

33176134 | J:299937

First Author:	Rodriguez-Romaguera J
Year:	2020
Journal:	Cell Rep
Title:	Prepronociceptin-Expressing Neurons in the Extended Amygdala Encode and Promote Rapid Arousal Responses to Motivationally Salient Stimuli.
Volume:	33
Issue:	6
Pages:	108362

•

Publication

37698928 | J:342906

First Author:	Kho I
Year:	2023
Journal:	JCI Insight
Title:	Severe kidney dysfunction in sialidosis mice reveals an essential role for neuraminidase 1 in reabsorption.
Volume:	8
Issue:	20

•

Publication

17717151 | -

First Author:	Rosado CJ
Year:	2007
Journal:	Science
Title:	A common fold mediates vertebrate defense and bacterial attack.
Volume:	317
Issue:	5844
Pages:	1548-51

•

Publication

34160349 | J:313902

First Author:	Tang CC
Year:	2021
Journal:	Elife
Title:	Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption.
Volume:	10

•

Publication

29273772 | J:258015

First Author:	Apicco DJ
Year:	2018
Journal:	Nat Neurosci
Title:	Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo.
Volume:	21
Issue:	1
Pages:	72-80

•

Publication

31825825 | J:292698

First Author:	Feng WW
Year:	2019
Journal:	Cell Rep
Title:	CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies.
Volume:	29
Issue:	11
Pages:	3405-3420.e5

•

Publication

19008197 | -

First Author:	Visnes T
Year:	2009
Journal:	Philos Trans R Soc Lond B Biol Sci
Title:	Uracil in DNA and its processing by different DNA glycosylases.
Volume:	364
Issue:	1517
Pages:	563-8

•

Publication

29596604 | -

First Author:	Earl C
Year:	2018
Journal:	Nucleic Acids Res
Title:	A structurally conserved motif in γ-herpesvirus uracil-DNA glycosylases elicits duplex nucleotide-flipping.
Volume:	46
Issue:	8
Pages:	4286-4300

•

Protein Domain

IPR002043 | UDG_fam1

Type:

Family

Description:

Uracil-DNA glycosylase (UDG, UNG) []is a DNA repair enzyme that excises uracil residues from DNA by cleaving the N-glycosylic bond. Uracil in DNA can arise as a result of mis-incorporation of dUMP residues by DNA polymerase or deamination of cytosine. UDGs were classified into 4 families [, ].Family 1 enzymes are active against uracil in both ssDNA and dsDNA, and recognise uracil explicitly in an extrahelical conformation via a combination of protein and bound-water interactions []. Family 1 enzymes are present in Eubacteria, Eukarya and in some eukaryotic viruses. The sequence of uracil-DNA glycosylases is extremely well conserved []in bacteria and eukaryotes as well as in herpes viruses []. More distantly related uracil-DNA glycosylases are also found in poxviruses []. In eukaryotic cells, UNG activity is found in both the nucleus and the mitochondria. Human nuclear UNG2 and mitochondrial UNG1are both encoded by the UNG gene [, ]. The N-terminal 77 amino acids of UNG1 seem to be required for mitochondrial localisation []. The catalytic C-terminal domains of UNGs are highly conserved at both the sequence and structure level while the N-terminal domains are diverse and are thought to be involved in subcellular localisation and protein-protein interactions [].

•

Publication

3052275 | -

First Author:	Sancar A
Year:	1988
Journal:	Annu Rev Biochem
Title:	DNA repair enzymes.
Volume:	57

Pages:	29-67

•

Publication

8332455 | -

First Author:	Slupphaug G
Year:	1993
Journal:	Nucleic Acids Res
Title:	Nuclear and mitochondrial forms of human uracil-DNA glycosylase are encoded by the same gene.
Volume:	21
Issue:	11
Pages:	2579-84

•

Protein

A0A0G2JDS8

Organism:	Mus musculus/domesticus
Length:	132
Fragment?:	false

•

Protein

P97931

Organism:	Mus musculus/domesticus
Length:	306
Fragment?:	false

•

Protein

D3YW18

Organism:	Mus musculus/domesticus
Length:	185
Fragment?:	true

•

Publication

11483530 | J:70852

First Author:	Nilsen H
Year:	2001
Journal:	EMBO J
Title:	Excision of deaminated cytosine from the vertebrate genome: role of the SMUG1 uracil-DNA glycosylase.
Volume:	20
Issue:	15
Pages:	4278-86

•

Publication

20065039 | J:161735

First Author:	Lauritzen KH
Year:	2010
Journal:	Mol Cell Biol
Title:	Mitochondrial DNA toxicity in forebrain neurons causes apoptosis, neurodegeneration, and impaired behavior.
Volume:	30
Issue:	6
Pages:	1357-67

•

Publication

29496532 | J:329569

First Author:	Green B
Year:	2018
Journal:	Exp Hematol
Title:	Deficiency in the DNA glycosylases UNG1 and OGG1 does not potentiate c-Myc-induced B-cell lymphomagenesis.
Volume:	61

Pages:	52-58

•

Publication

11223884 | -

First Author:	Schärer OD
Year:	2001
Journal:	Bioessays
Title:	Recent progress in the biology, chemistry and structural biology of DNA glycosylases.
Volume:	23
Issue:	3
Pages:	270-81

•

Publication

10946227 | -

First Author:	Pearl LH
Year:	2000
Journal:	Mutat Res
Title:	Structure and function in the uracil-DNA glycosylase superfamily.
Volume:	460
Issue:	3-4
Pages:	165-81

•

Publication

7845459 | -

First Author:	Savva R
Year:	1995
Journal:	Nature
Title:	The structural basis of specific base-excision repair by uracil-DNA glycosylase.
Volume:	373
Issue:	6514
Pages:	487-93

•

Protein Domain

IPR018085 | Ura-DNA_Glyclase_AS

Type:

Active_site

Description:

Uracil-DNA glycosylase (UNG) []is a DNA repair enzyme that excises uracil residues from DNA by cleaving the N-glycosylic bond. Uracil in DNA can arise as a result of mis-incorporation of dUMP residues by DNA polymerase or deamination of cytosine.The sequence of uracil-DNA glycosylase is extremely well conserved []in bacteria and eukaryotes as well as in herpes viruses. More distantly related uracil-DNA glycosylases are also found in poxviruses []. In eukaryotic cells, UNG activity is found in both the nucleus and the mitochondria. Human UNG1 protein is transported to both the mitochondria and the nucleus []. The N-terminal 77 amino acids of UNG1 seem to be required for mitochondrial localisation [], but the presence of a mitochondrial transitpeptide has not been directly demonstrated. The most N-terminal conserved region contains an aspartic acid residue which has been proposed, based on X-ray structures [, ]to act as a general base in the catalytic mechanism.This signature pattern covers the most N-terminal conserved region, which contains an aspartic acid residue that has been proposed, based on X-ray structures [, ]to act as a general base in the catalytic mechanism.

•

Publication

2555154 | -

First Author:	Olsen LC
Year:	1989
Journal:	EMBO J
Title:	Molecular cloning of human uracil-DNA glycosylase, a highly conserved DNA repair enzyme.
Volume:	8
Issue:	10
Pages:	3121-5

•

Publication

8389453 | -

First Author:	Upton C
Year:	1993
Journal:	Proc Natl Acad Sci U S A
Title:	Identification of a poxvirus gene encoding a uracil DNA glycosylase.
Volume:	90
Issue:	10
Pages:	4518-22

•

Publication

12718543 | J:83349

First Author:	Masaoka A
Year:	2003
Journal:	Biochemistry
Title:	Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions.
Volume:	42
Issue:	17
Pages:	5003-12

•

Publication

17591858 | J:125867

First Author:	Wu X
Year:	2007
Journal:	J Exp Med
Title:	DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination.
Volume:	204
Issue:	7
Pages:	1677-89

•

Publication

34819671 | J:322351

First Author:	Rogier M
Year:	2021
Journal:	Nature
Title:	Fam72a enforces error-prone DNA repair during antibody diversification.
Volume:	600
Issue:	7888
Pages:	329-333

•

Publication

35450882 | J:343116

First Author:	Wu L
Year:	2022
Journal:	Genes Dev
Title:	HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation.
Volume:	36
Issue:	7-8
Pages:	433-450

•

Publication

26267846 | J:242780

First Author:	Kadungure T
Year:	2015
Journal:	PLoS One
Title:	Individual substitution mutations in the AID C terminus that ablate IgH class switch recombination.
Volume:	10
Issue:	8
Pages:	e0134397

•

Publication

7697717 | -

First Author:	Mol CD
Year:	1995
Journal:	Cell
Title:	Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis.
Volume:	80
Issue:	6
Pages:	869-78

•

Questions? Comments? Click here!

MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Your name:
Your email address:
Subject:
Message:	---- Current page: ---- /mousemine/keywordSearchResults.do;jsessionid=AB4390FE4357DA6BA3A401C970B83E8E?searchTerm=Ung&searchBag=&searchOffset=500

MouseMine

Search our database by keyword

Examples

Search results 501 to 531 out of 531 for Ung

Categories

Hits by Pathway

Hits by Strain

Hits by Category