ODF1 is a component of the outer dense fibres (ODF), which are cytoskeletal structures specifically found in the sperm tails of vertebrates. ODF1 has been assigned to the heat shock protein family based on its overall structural features and especially on its conserved alpha-crystallin domain, and it is also known as HSPB10 []. ODF1 is essential for tight linkage of sperm head to tail and is essential for male fertility [].This entry represents the alpha crystallin domain (ACD) of ODF1.
ODF1 is a component of the outer dense fibres (ODF), which are cytoskeletal structures specifically found in the sperm tails of vertebrates. ODF1 has been assigned to the heat shock protein family based on its overall structural features and especially on its conserved alpha-crystallin domain, and it is also known as HSPB10 []. ODF1 is essential for tight linkage of sperm head to tail and is essential for male fertility [].
Sperm-associated antigen 4 protein (SPAG4, also known as SUN4) is a SUN domain containing protein that was originally isolated from the testis []. It binds outer dense-fibre protein Odf1 and localises to microtubules of manchette and axoneme []. SPAG4 was later found expressed ubiquitously in various normal tissues and neoplastic tissues in humans at the mRNA level []. In renal cell carcinoma, SPAG4 is an independent prognostic factor and plays a crucial role in cytokinesis to defend against hypoxia-induced tetraploid formation []. It also promotes renal clear cell carcinoma migration and invasion in vitro [].This entry represents SPAG4 from mammals.
