N-myc downstream regulated gene (NDRG) family members are characterised by an alpha/beta hydrolase-fold motif. NDRG proteins may function as tumour suppressors and may also play important roles in the development of neurological and electrophysiological diseases [, ]. This entry represents NDRG4. It is expressed in brain and heart []. NDRG4 is required for normal myocyte proliferation during early cardiac development in zebrafish []. It plays a role in neurite outgrowth and has an influence on nerve growth factor (NGF)-stimulated transcription factor AP-1 activation []. It has been linked to prolongation of the QT interval, a cardiac electrophysiological disorder that might predispose to sudden cardiac death and ventricular arrhythmias [, ].
