Epsin-3 belongs to the Epsin family, whose members contain a conserved ENTH (epsin N-terminal homology) domain. In humans, Epsin-3 is detected in chronic wounds, basal cell carcinoma and ulcerative colitis. Epsin-3 may play a role in activated epithelial cells during tissue morphogenesis []. Upregulation of the EPN3 gene is specifically associated with invasive, aggressive cancers [].
