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Search results 1001 to 1077 out of 1077 for Six1

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Type Details Score
Publication
19726883 | J:152693
First Author: McCoy EL
Year: 2009
Journal: J Clin Invest
Title: Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition.
Volume: 119
Issue: 9
Pages: 2663-77
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HT Experiment
E-GEOD-50023 | Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle
Series Id: GSE50023
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
26500063 | J:226084
First Author: Adrados I
Year: 2016
Journal: Oncogene
Title: The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4A and differentiation-related genes.
Volume: 35
Issue: 27
Pages: 3485-94
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GXD Expression
GXD Expression
Probe: MGI:6504940
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6504949
Age: embryonic day 10.5
Image: 4A
Note: Co-expression with Six1 in nuclei of myogenic progenitor cells.
Specimen Label: 4A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4833962
Assay Type: RNA in situ
Annotation Date: 2010-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1606912
Pattern: Regionally restricted
Stage: TS12
Assay Id: MGI:4833966
Age: embryonic day 8.0
Note: Expression is present in the anterior neural ridge. There was overlap with Six1 expression.
Specimen Label: Not shown
Detected: true
Specimen Num: 1
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Publication
21706047 | -
First Author: Farabaugh SM
Year: 2012
Journal: Oncogene
Title: Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-β signaling, epithelial-mesenchymal transition, and cancer stem cell properties.
Volume: 31
Issue: 5
Pages: 552-62
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Publication
11978764 | -
First Author: Sato S
Year: 2002
Journal: Hum Mol Genet
Title: Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1.
Volume: 11
Issue: 9
Pages: 1045-58
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Interaction Experiment
Ahmed M (2012)
Description: EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear.
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DO Term
DOID:0110553 | autosomal dominant nonsyndromic deafness 23
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Allele
Tg(Rr239-lacZ)#Kwk | MGI:7330177
Name: transgene insertion, Kiyoshi Kawakami
Allele Type: Transgenic
Attribute String: Reporter
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Allele
Tg(Rr234-lacZ)#Kwk | MGI:7330173
Name: transgene insertion, Kiyoshi Kawakami
Allele Type: Transgenic
Attribute String: Reporter
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Allele
Eya1<tm4(Six1)Px> | MGI:7328385
Name: EYA transcriptional coactivator and phosphatase 1; targeted mutation 4, Pin-Xian Xu
Allele Type: Targeted
Attribute String: Inserted expressed sequence
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Allele
Tg(Rr235-lacZ)#Kwk | MGI:7330174
Name: transgene insertion, Kiyoshi Kawakami
Allele Type: Transgenic
Attribute String: Reporter
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Allele
Tg(Rr238-lacZ)#Shisa | MGI:7330087
Name: transgene insertion, Shigeru Sato
Allele Type: Transgenic
Attribute String: Reporter
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Allele
Tg(Rr233-lacZ)#Kwk | MGI:7330172
Name: transgene insertion, Kiyoshi Kawakami
Allele Type: Transgenic
Attribute String: Reporter
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Allele
Tg(Rr237-lacZ)#Kwk | MGI:7330176
Name: transgene insertion, Kiyoshi Kawakami
Allele Type: Transgenic
Attribute String: Reporter
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Allele
Tg(Rr236-lacZ)#Kwk | MGI:7330175
Name: transgene insertion, Kiyoshi Kawakami
Allele Type: Transgenic
Attribute String: Reporter
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Allele
Tg(Rr240-lacZ)#Kwk | MGI:7330178
Name: transgene insertion, Kiyoshi Kawakami
Allele Type: Transgenic
Attribute String: Reporter
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HT Experiment
GSE73866 | Transcriptional profiling of human and mouse nephron progenitor cells
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Allele
Tg(Rr238-lacZ)x4Shisa | MGI:7330088
Name: transgene insertion x4, Shigeru Sato
Allele Type: Transgenic
Attribute String: Reporter
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DO Term
DOID:0060232 | branchiootic syndrome
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HT Experiment
E-GEOD-30076 | Transcription profiling by array of mouse heart mutant for Ezh2
Series Id: GSE30076
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Allele
Six1<tm1(cre)Xli> | MGI:5014213
Name: sine oculis-related homeobox 1; targeted mutation 1, Xue Li
Allele Type: Targeted
Attribute String: Recombinase
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Allele
Tg(Six1-cre)1Kwk | MGI:5698451
Name: transgene insertion 1, Kiyoshi Kawakami
Allele Type: Transgenic
Attribute String: Recombinase
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Genotype
Genotype
Symbol: Eya1/Eya1<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
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Allele
Tg(Rr238*-lacZ)x4Shisa | MGI:7330089
Name: transgene insertion x4, Shigeru Sato
Allele Type: Transgenic
Attribute String: Reporter
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Allele
Tg(Rr232-lacZ)#Kwk | MGI:7330171
Name: transgene insertion, Kiyoshi Kawakami
Allele Type: Transgenic
Attribute String: Reporter
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Genotype
Genotype
Symbol: Six1/Six1<+>
Background: involves: 129
Zygosity: ht
Has Mutant Allele: true
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HT Experiment
E-GEOD-34274 | Gene expression profile of right ventricles from adult wild type and Ezh2-deficient hearts
Series Id: GSE34274
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein Domain
IPR028473 | EYA2
Type: Family
Description: Members of the eye absent (EYA) family were originally characterised in fly eye development. EYA proteins are both transcriptional activators and tyrosine phosphatases [, ], and have been shown to dephosphorylate H2AX, promoting repair and cell survival in the response to DNA damage []. EYA proteins (EYA1-4) are normally expressed early in development [, ]. Their phosphatase activity regulates Six1-Dach-Eya transcriptional effects in precursor cell proliferation and survival in mammalian organogenesis [].EYA2 plays an important role in hypaxial muscle development together with Six1 and Dach2; in this it is functionally redundant with EYA1 []. EYA2 is a necessary co-factor for many of the metastasis promoting functions of Six1 [].
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Publication
23435380 | -
First Author: Patrick AN
Year: 2013
Journal: Nat Struct Mol Biol
Title: Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome.
Volume: 20
Issue: 4
Pages: 447-53
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Protein Domain
IPR031701 | SIX1_SD
Type: Domain
Description: The SD domain is found N-terminal to the homeobox domain in the protein SIX1. As a transcription factor, SIX1 lacks intrinsic activation domains and thus needs to bind to the EYA family of co-factors in order to mediate transcriptional activation. The SD domain is necessary for this protein-protein interaction, binding to the C-terminal region of EYA (Eyes absent homologue proteins) [].
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Allele
Tg(tetO-SIX1)#Hlf | MGI:5795965
Name: transgene insertion, Heide L Ford
Allele Type: Transgenic
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence
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Allele
Tg(Six1-cre)2Kwk | MGI:5700048
Name: transgene insertion 2, Kiyoshi Kawakami
Allele Type: Transgenic
Attribute String: Recombinase
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Genotype
Genotype
Symbol: Eya1/Eya1<+> Six2/Six2
Background: Not Specified
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Six1-cre)1Kwk/?
Background: involves: 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Protein Domain
IPR028479 | EYA3
Type: Family
Description: Members of the eye absent (EYA) family were originally characterised in fly eye development. EYA proteins are both transcriptional activators and tyrosine phosphatases [, ], and have been shown to dephosphorylate H2AX, promoting repair and cell survival in the response to DNA damage []. EYA proteins (EYA1-4) are normally expressed early in development [, ]. Their phosphatase activity regulates Six1-Dach-Eya transcriptional effects in precursor cell proliferation and survival in mammalian organogenesis [].EYA3 forms a complex with Six1 and Ski that regulates muscle terminal differentiation [].
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Genotype
Genotype
Symbol: Fgf8/Fgf8<+> Six1/Six1<+>
Background: involves: 129 * 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ctnnb1/Ctnnb1<+> Six1/Six1<+>
Background: involves: 129
Zygosity: cn
Has Mutant Allele: true
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Publication
9887327 | J:52368
First Author: Borsani G
Year: 1999
Journal: Hum Mol Genet
Title: EYA4, a novel vertebrate gene related to Drosophila eyes absent.
Volume: 8
Issue: 1
Pages: 11-23
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Publication
9020840 | J:38771
First Author: Abdelhak S
Year: 1997
Journal: Nat Genet
Title: A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family.
Volume: 15
Issue: 2
Pages: 157-64
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Publication
19234442 | J:147286
First Author: Cook PJ
Year: 2009
Journal: Nature
Title: Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions.
Volume: 458
Issue: 7238
Pages: 591-6
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Publication
17341163 | -
 
First Author: Jemc J
Year: 2007
Journal: Annu Rev Biochem
Title: The eyes absent family of phosphotyrosine phosphatases: properties and roles in developmental regulation of transcription.
Volume: 76
Pages: 513-38
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Protein
Q3TP96
Organism: Mus musculus/domesticus
Length: 286  
Fragment?: false
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Protein
A2A953
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Six1/Six1<+>
Background: involves: 129/Sv * 129S4/SvJaeSor
Zygosity: cn
Has Mutant Allele: true
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Publication
25816987 | J:239288
First Author: Eisner A
Year: 2015
Journal: Dev Cell
Title: The Eya1 phosphatase promotes Shh signaling during hindbrain development and oncogenesis.
Volume: 33
Issue: 1
Pages: 22-35
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Publication
17540357 | J:122955
First Author: L'Honoré A
Year: 2007
Journal: Dev Biol
Title: Sequential expression and redundancy of Pitx2 and Pitx3 genes during muscle development.
Volume: 307
Issue: 2
Pages: 421-33
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Publication
29483821 | J:272082
First Author: Wang H
Year: 2018
Journal: Int J Biol Sci
Title: Disruption of Gen1 Causes Congenital Anomalies of the Kidney and Urinary Tract in Mice.
Volume: 14
Issue: 1
Pages: 10-20
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Six1-cre)2Kwk/?
Background: involves: 129S4/SvJaeSor * C57BL/6J * DBA/2J
Zygosity: cn
Has Mutant Allele: true
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Protein
Q3TPT0
Organism: Mus musculus/domesticus
Length: 44  
Fragment?: true
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Publication
14628053 | -
First Author: Tootle TL
Year: 2003
Journal: Nature
Title: The transcription factor Eyes absent is a protein tyrosine phosphatase.
Volume: 426
Issue: 6964
Pages: 299-302
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Publication
32277572 | J:292650
First Author: Li C
Year: 2020
Journal: Genesis
Title: Generation and characterization of Six2 conditional mice.
Volume: 58
Issue: 7
Pages: e23365
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Publication
31227770 | J:278634
First Author: Wilkerson BA
Year: 2019
Journal: Sci Rep
Title: Open chromatin dynamics in prosensory cells of the embryonic mouse cochlea.
Volume: 9
Issue: 1
Pages: 9060
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Publication
21129973 | J:171851
First Author: Masumoto KH
Year: 2010
Journal: Curr Biol
Title: Acute induction of Eya3 by late-night light stimulation triggers TSHβ expression in photoperiodism.
Volume: 20
Issue: 24
Pages: 2199-206
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Publication
11856745 | J:76366
First Author: Petropoulos H
Year: 2002
Journal: J Biol Chem
Title: Beta-catenin is essential and sufficient for skeletal myogenesis in P19 cells.
Volume: 277
Issue: 18
Pages: 15393-9
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Publication
24465223 | J:226669
First Author: Ono K
Year: 2014
Journal: PLoS Genet
Title: FGFR1-Frs2/3 signalling maintains sensory progenitors during inner ear hair cell formation.
Volume: 10
Issue: 1
Pages: e1004118
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Publication
10508520 | J:57891
First Author: Schäfer K
Year: 1999
Journal: Nat Genet
Title: Early specification of limb muscle precursor cells by the homeobox gene Lbx1h.
Volume: 23
Issue: 2
Pages: 213-6
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Publication
27224259 | J:328184
First Author: Yajima H
Year: 2016
Journal: Dev Growth Differ
Title: Low Six4 and Six5 gene dosage improves dystrophic phenotype and prolongs life span of mdx mice.
Volume: 58
Issue: 6
Pages: 546-61
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Publication
24002655 | J:211174
First Author: Jefferson WN
Year: 2013
Journal: Mol Endocrinol
Title: Persistently altered epigenetic marks in the mouse uterus after neonatal estrogen exposure.
Volume: 27
Issue: 10
Pages: 1666-77
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Protein
O08575
Organism: Mus musculus/domesticus
Length: 532  
Fragment?: false
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Protein
Q811N8
Organism: Mus musculus/domesticus
Length: 450  
Fragment?: false
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Protein
Q3UV00
Organism: Mus musculus/domesticus
Length: 532  
Fragment?: false
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Protein
Q811N7
Organism: Mus musculus/domesticus
Length: 502  
Fragment?: false
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Protein
Q3UR62
Organism: Mus musculus/domesticus
Length: 614  
Fragment?: true
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Publication
18602390 | J:141881
First Author: Paper W
Year: 2008
Journal: Exp Eye Res
Title: Elevated amounts of myocilin in the aqueous humor of transgenic mice cause significant changes in ocular gene expression.
Volume: 87
Issue: 3
Pages: 257-67
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Protein
Q62233
Organism: Mus musculus/domesticus
Length: 333  
Fragment?: false
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Protein
Q9QZ28
Organism: Mus musculus/domesticus
Length: 246  
Fragment?: false
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Protein
B2RSE8
Organism: Mus musculus/domesticus
Length: 246  
Fragment?: false
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Protein
Q52KB8
Organism: Mus musculus/domesticus
Length: 347  
Fragment?: false
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Protein
P97480
Organism: Mus musculus/domesticus
Length: 510  
Fragment?: false
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Protein
Q62232
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: false
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Protein
Q61321
Organism: Mus musculus/domesticus
Length: 775  
Fragment?: false
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Protein
P70178
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
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Protein
Q6P4T3
Organism: Mus musculus/domesticus
Length: 526  
Fragment?: false
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Protein
H3BL91
Organism: Mus musculus/domesticus
Length: 518  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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