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Search results 201 to 300 out of 1141 for Aim2

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Type Details Score
GO Term
GO:0140972 | negative regulation of AIM2 inflammasome complex assembly
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Protein
D3Z341
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Protein
G3UZ36
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: true
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Publication
29855523 | J:323710
First Author: Rodrigue-Gervais IG
Year: 2018
Journal: Sci Rep
Title: The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes.
Volume: 8
Issue: 1
Pages: 8446
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Publication
24270411 | J:229062
First Author: Wu YH
Year: 2014
Journal: Cell Death Differ
Title: Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation.
Volume: 21
Issue: 3
Pages: 451-61
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Publication
31822523 | J:315641
First Author: Cho SJ
Year: 2020
Journal: Thorax
Title: GLUT1-dependent glycolysis regulates exacerbation of fibrosis via AIM2 inflammasome activation.
Volume: 75
Issue: 3
Pages: 227-236
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Interaction Experiment
Liu T (2016)
Description: TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy.
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Publication
24798340 | J:216031
First Author: Zhao C
Year: 2014
Journal: J Biol Chem
Title: Nuclear factor E2-related factor-2 (Nrf2) is required for NLRP3 and AIM2 inflammasome activation.
Volume: 289
Issue: 24
Pages: 17020-9
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Publication
31914678 | J:299487
First Author: Zhang MJ
Year: 2020
Journal: FASEB J
Title: The HDAC3 inhibitor RGFP966 ameliorated ischemic brain damage by downregulating the AIM2 inflammasome.
Volume: 34
Issue: 1
Pages: 648-662
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Publication
34861878 | J:324799
First Author: Cao LL
Year: 2021
Journal: J Neuroinflammation
Title: Downregulating expression of OPTN elevates neuroinflammation via AIM2 inflammasome- and RIPK1-activating mechanisms in APP/PS1 transgenic mice.
Volume: 18
Issue: 1
Pages: 281
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Publication
32001670 | J:297765
First Author: Yuan B
Year: 2020
Journal: Cell Death Dis
Title: Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage.
Volume: 11
Issue: 1
Pages: 76
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Publication
34471287 | -
First Author: Lee S
Year: 2021
Journal: Nature
Title: AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence.
Volume: 597
Issue: 7876
Pages: 415-419
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Allele
Aim2<em2Smoc> | MGI:7288204
Name: absent in melanoma 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
15896773 | -
First Author: Ludlow LE
Year: 2005
Journal: Exp Cell Res
Title: The HIN-200 family: more than interferon-inducible genes?
Volume: 308
Issue: 1
Pages: 1-17
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Protein Coding Gene
MGI:1347080 | Ifi202a
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Aim2<em1Smoc> | MGI:7288203
Name: absent in melanoma 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Publication
25327779 | -
First Author: Kim HY
Year: 2015
Journal: FEBS J
Title: Activation of NLRP3 and AIM2 inflammasomes in Kupffer cells in hepatic ischemia/reperfusion.
Volume: 282
Issue: 2
Pages: 259-70
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Publication
22483801 | -
First Author: Jin T
Year: 2012
Journal: Immunity
Title: Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor.
Volume: 36
Issue: 4
Pages: 561-71
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Pseudogene
MGI:3649299 | Gm12250
Type: pseudogene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2137355 | Trim11
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96544 | Casp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1312922 | Casp12
Type: protein_coding_gene
Organism: mouse, laboratory
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Pseudogene
MGI:3840117 | Ifi203-ps
Type: pseudogene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3646410 | Ifi206
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2442822 | Ifi208
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3695276 | Ifi213
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2138243 | Ifi209
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3584522 | Ifi214
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2138302 | Ifi207
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3780953 | Mndal
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96428 | Ifi203
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2429943 | Gbp5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:102772 | Gbp2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107700 | Casp4
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Del(1Aim2-Ifi205)1Stsn | MGI:5789602
Name: deletion, Chr 1, Daniel Stetson 1
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
22258606 | J:320140
First Author: Strowig T
Year: 2012
Journal: Nature
Title: Inflammasomes in health and disease.
Volume: 481
Issue: 7381
Pages: 278-86
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Publication
26140588 | J:224532
First Author: Rommereim LM
Year: 2015
Journal: Cell
Title: AIMing 2 Curtail Cancer.
Volume: 162
Issue: 1
Pages: 18-20
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Publication
24492532 | J:244194
 
First Author: Van Opdenbosch N
Year: 2014
Journal: Nat Commun
Title: Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation.
Volume: 5
Pages: 3209
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Strain
MGI:5789962 | B6(129S4)-Del(1Aim2-Ifi205)1Stsn
Attribute String: mutant strain, targeted mutation, chromosome aberration, deletion
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Strain
MGI:5789626 | B6(129S4)-Del(1Aim2-Ifi205)1Stsn/J
Attribute String: mutant strain, deletion
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Genotype
Genotype
Symbol: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn
Background: B6(129S4)-Del(1Aim2-Ifi205)1Stsn
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn
Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N
Zygosity: hm
Has Mutant Allele: true
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Publication
28345580 | J:263294
 
First Author: Man SM
Year: 2017
Journal: Sci Rep
Title: Differential roles of caspase-1 and caspase-11 in infection and inflammation.
Volume: 7
Pages: 45126
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Publication
27800616 | J:247253
First Author: Silveira TN
Year: 2017
Journal: Eur J Immunol
Title: NLRP12 negatively regulates proinflammatory cytokine production and host defense against Brucella abortus.
Volume: 47
Issue: 1
Pages: 51-59
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Publication
24407287 | J:219619
First Author: Dowling JK
Year: 2014
Journal: J Biol Chem
Title: Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation.
Volume: 289
Issue: 10
Pages: 6429-37
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Publication
21957143 | J:179435
First Author: Fang R
Year: 2011
Journal: J Immunol
Title: Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection.
Volume: 187
Issue: 9
Pages: 4890-9
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Publication
36070769 | J:329937
First Author: Maltbaek JH
Year: 2022
Journal: Immunity
Title: ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP.
Volume: 55
Issue: 10
Pages: 1799-1812.e4
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Genotype
Genotype
Symbol: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn Trex1/Trex1
Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(1Aim2-Ifi205)1Stsn/+ Trex1/Trex1
Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N
Zygosity: cx
Has Mutant Allele: true
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Protein Coding Gene
MGI_C57BL6J_1347080 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
11567633 | J:123266
First Author: Rozzo SJ
Year: 2001
Journal: Immunity
Title: Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus.
Volume: 15
Issue: 3
Pages: 435-43
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Publication
1382418 | J:2375
First Author: Lembo D
Year: 1992
Journal: Biochem Biophys Res Commun
Title: Regulation of the 202 gene expression by interferons in L929 cells.
Volume: 187
Issue: 2
Pages: 628-34
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Publication
8454910 | J:17917
First Author: Choubey D
Year: 1993
Journal: J Interferon Res
Title: Interferon action: cytoplasmic and nuclear localization of the interferon-inducible 52-kD protein that is encoded by the Ifi 200 gene from the gene 200 cluster.
Volume: 13
Issue: 1
Pages: 43-52
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Publication
8524315 | J:31083
First Author: Min W
Year: 1996
Journal: Mol Cell Biol
Title: The interferon-inducible p202 protein as a modulator of transcription: inhibition of NF-kappa B, c-Fos, and c-Jun activities.
Volume: 16
Issue: 1
Pages: 359-68
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Publication
30930743 | J:310545
 
First Author: Pronin A
Year: 2019
Journal: Front Mol Neurosci
Title: Inflammasome Activation Induces Pyroptosis in the Retina Exposed to Ocular Hypertension Injury.
Volume: 12
Pages: 36
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Protein Coding Gene
MGI:1931465 | Pycard
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
25043000 | J:217119
First Author: Walle LV
Year: 2014
Journal: Nature
Title: Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis.
Volume: 512
Issue: 7512
Pages: 69-73
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Publication
26814970 | J:229240
First Author: He Y
Year: 2016
Journal: Nature
Title: NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux.
Volume: 530
Issue: 7590
Pages: 354-7
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Publication
30777924 | J:273125
First Author: Murakami T
Year: 2019
Journal: J Immunol
Title: Cutting Edge: G Protein Subunit β 1 Negatively Regulates NLRP3 Inflammasome Activation.
Volume: 202
Issue: 7
Pages: 1942-1947
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Publication
27035940 | J:232121
First Author: Monteith AJ
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Defects in lysosomal maturation facilitate the activation of innate sensors in systemic lupus erythematosus.
Volume: 113
Issue: 15
Pages: E2142-51
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Publication
20890285 | J:166541
First Author: Unterholzner L
Year: 2010
Journal: Nat Immunol
Title: IFI16 is an innate immune sensor for intracellular DNA.
Volume: 11
Issue: 11
Pages: 997-1004
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Publication
36844454 | J:334452
First Author: Traughber CA
Year: 2023
Journal: iScience
Title: Myeloid-cell-specific role of Gasdermin D in promoting lung cancer progression in mice.
Volume: 26
Issue: 2
Pages: 106076
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Publication
27270400 | J:244991
First Author: Akula MK
Year: 2016
Journal: Nat Immunol
Title: Control of the innate immune response by the mevalonate pathway.
Volume: 17
Issue: 8
Pages: 922-9
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Publication
34010627 | J:328725
First Author: Avgustinova A
Year: 2021
Journal: Cell Stem Cell
Title: Repression of endogenous retroviruses prevents antiviral immune response and is required for mammary gland development.
Volume: 28
Issue: 10
Pages: 1790-1804.e8
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Publication
36103544 | J:331763
First Author: de Almeida L
Year: 2022
Journal: Sci Adv
Title: Identification of immunomodulatory drugs that inhibit multiple inflammasomes and impair SARS-CoV-2 infection.
Volume: 8
Issue: 37
Pages: eabo5400
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Publication
32791101 | J:295186
First Author: Hooftman A
Year: 2020
Journal: Cell Metab
Title: The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation.
Volume: 32
Issue: 3
Pages: 468-478.e7
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Publication
23100513 | J:190677
First Author: Hernandez-Cuellar E
Year: 2012
Journal: J Immunol
Title: Cutting edge: nitric oxide inhibits the NLRP3 inflammasome.
Volume: 189
Issue: 11
Pages: 5113-7
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Publication
28397782 | J:250403
 
First Author: Zhong Z
Year: 2017
Journal: Nat Commun
Title: Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice.
Volume: 8
Pages: 15004
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Publication
29531021 | J:262083
 
First Author: Huang Y
Year: 2018
Journal: EMBO Mol Med
Title: Tranilast directly targets NLRP3 to treat inflammasome-driven diseases.
Volume: 10
Issue: 4
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Publication
22105559 | J:187797
First Author: Luheshi NM
Year: 2012
Journal: Eur J Immunol
Title: Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages.
Volume: 42
Issue: 3
Pages: 716-25
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Publication
30940803 | J:276765
First Author: Zhang P
Year: 2019
Journal: Nat Commun
Title: The lncRNA Neat1 promotes activation of inflammasomes in macrophages.
Volume: 10
Issue: 1
Pages: 1495
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Publication
31597705 | J:282055
First Author: Chen Y
Year: 2019
Journal: J Immunol
Title: Gasdermin D Drives the Nonexosomal Secretion of Galectin-3, an Insulin Signal Antagonist.
Volume: 203
Issue: 10
Pages: 2712-2723
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Publication
31914640 | J:299490
First Author: Shi Y
Year: 2020
Journal: FASEB J
Title: Ginsenoside Rg3 suppresses the NLRP3 inflammasome activation through inhibition of its assembly.
Volume: 34
Issue: 1
Pages: 208-221
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Publication
24419611 | J:333978
First Author: Li H
Year: 2014
Journal: Acta Crystallogr F Struct Biol Commun
Title: Structural mechanism of DNA recognition by the p202 HINa domain: insights into the inhibition of Aim2-mediated inflammatory signalling.
Volume: 70
Issue: Pt 1
Pages: 21-9
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Publication
10493828 | J:57929
First Author: Wang H
Year: 1999
Journal: Genomics
Title: Characteristics of three homologous 202 genes (Ifi202a, Ifi202b, and Ifi202c) from the murine interferon-activatable gene 200 cluster.
Volume: 60
Issue: 3
Pages: 281-94
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Publication
16670293 | J:131681
First Author: Xin H
Year: 2006
Journal: J Immunol
Title: Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosis.
Volume: 176
Issue: 10
Pages: 5863-70
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Publication
2457983 | J:9335
First Author: Engel DA
Year: 1988
Journal: Virology
Title: Interferons as gene activators: close linkage of two interferon-activatable murine genes.
Volume: 166
Issue: 1
Pages: 24-9
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Publication
17702989 | J:124676
First Author: Yamauchi M
Year: 2007
Journal: Int Immunol
Title: Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-kappaB activation in dendritic cells.
Volume: 19
Issue: 8
Pages: 935-42
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Publication
31836654 | J:289587
First Author: Bhatta A
Year: 2020
Journal: J Immunol
Title: A Mitochondrial Micropeptide Is Required for Activation of the Nlrp3 Inflammasome.
Volume: 204
Issue: 2
Pages: 428-437
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Publication
22156592 | J:180799
First Author: Koppe U
Year: 2012
Journal: J Immunol
Title: Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungs.
Volume: 188
Issue: 2
Pages: 811-7
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Publication
26590319 | J:253725
First Author: Suschak JJ
Year: 2016
Journal: J Immunol
Title: A cGAS-Independent STING/IRF7 Pathway Mediates the Immunogenicity of DNA Vaccines.
Volume: 196
Issue: 1
Pages: 310-6
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Publication
33721834 | J:339056
 
First Author: Wu M
Year: 2021
Journal: Biochem Biophys Res Commun
Title: cGAS promotes sepsis in radiotherapy of cancer by up-regulating caspase-11 signaling.
Volume: 551
Pages: 86-92
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Publication
28935571 | J:252318
First Author: Durga Devi T
Year: 2017
Journal: Am J Pathol
Title: Aggravated Postinfarct Heart Failure in Type 2 Diabetes Is Associated with Impaired Mitophagy and Exaggerated Inflammasome Activation.
Volume: 187
Issue: 12
Pages: 2659-2673
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Publication
33552083 | J:316719
 
First Author: Song L
Year: 2020
Journal: Front Immunol
Title: Activation of the Nlrp3 Inflammasome Contributes to Shiga Toxin-Induced Hemolytic Uremic Syndrome in a Mouse Model.
Volume: 11
Pages: 619096
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Publication
28928425 | J:287703
First Author: Manils J
Year: 2017
Journal: Sci Rep
Title: Double deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses.
Volume: 7
Issue: 1
Pages: 11902
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Publication
26582950 | J:240016
First Author: Moriwaki K
Year: 2016
Journal: J Immunol
Title: The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages.
Volume: 196
Issue: 1
Pages: 407-15
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Publication
20008285 | J:159411
First Author: Meixenberger K
Year: 2010
Journal: J Immunol
Title: Listeria monocytogenes-infected human peripheral blood mononuclear cells produce IL-1beta, depending on listeriolysin O and NLRP3.
Volume: 184
Issue: 2
Pages: 922-30
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Publication
29549176 | J:260967
First Author: Yin H
Year: 2018
Journal: J Immunol
Title: Curcumin Suppresses IL-1β Secretion and Prevents Inflammation through Inhibition of the NLRP3 Inflammasome.
Volume: 200
Issue: 8
Pages: 2835-2846
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Publication
31170267 | J:288316
First Author: Lin L
Year: 2019
Journal: PLoS Pathog
Title: An NLRP3 inflammasome-triggered cytokine storm contributes to Streptococcal toxic shock-like syndrome (STSLS).
Volume: 15
Issue: 6
Pages: e1007795
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Publication
27806943 | J:238273
First Author: Plazyo O
Year: 2016
Journal: Biol Reprod
Title: HMGB1 Induces an Inflammatory Response in the Chorioamniotic Membranes That Is Partially Mediated by the Inflammasome.
Volume: 95
Issue: 6
Pages: 130
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Publication
27796369 | J:259915
 
First Author: Chung IC
Year: 2016
Journal: Sci Rep
Title: Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis.
Volume: 6
Pages: 36214
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Publication
29191979 | J:256176
First Author: Suzuki S
Year: 2018
Journal: EMBO Rep
Title: Shigella hijacks the glomulin-cIAPs-inflammasome axis to promote inflammation.
Volume: 19
Issue: 1
Pages: 89-101
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Publication
29051224 | J:255154
First Author: Son S
Year: 2017
Journal: J Biol Chem
Title: Advanced glycation end products impair NLRP3 inflammasome-mediated innate immune responses in macrophages.
Volume: 292
Issue: 50
Pages: 20437-20448
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Publication
30842273 | J:274373
First Author: Luo F
Year: 2019
Journal: J Immunol
Title: Nonreceptor Tyrosine Kinase c-Abl- and Arg-Mediated IRF3 Phosphorylation Regulates Innate Immune Responses by Promoting Type I IFN Production.
Volume: 202
Issue: 8
Pages: 2254-2265
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Publication
32038610 | J:297759
 
First Author: Arriola Benitez PC
Year: 2019
Journal: Front Immunol
Title: Brucella abortus Infection Elicited Hepatic Stellate Cell-Mediated Fibrosis Through Inflammasome-Dependent IL-1β Production.
Volume: 10
Pages: 3036
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Publication
33348068 | J:308765
 
First Author: Wortmann M
Year: 2021
Journal: Atherosclerosis
Title: The C57Bl/6J mouse strain is more susceptible to angiotensin II-induced aortic aneurysm formation than C57Bl/6N.
Volume: 318
Pages: 8-13
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Publication
34512673 | J:312743
 
First Author: Tang T
Year: 2021
Journal: Front Immunol
Title: The E3 Ubiquitin Ligase TRIM65 Negatively Regulates Inflammasome Activation Through Promoting Ubiquitination of NLRP3.
Volume: 12
Pages: 741839
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Publication
37497237 | J:338522
 
First Author: Deng Z
Year: 2023
Journal: Front Immunol
Title: The roles of inflammasomes in cancer.
Volume: 14
Pages: 1195572
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Protein Coding Gene
MGP_CAROLIEiJ_G0031743 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0034312 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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