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Search results 101 to 200 out of 415 for Trem2

0.039s
Type Details Score
Publication
First Author: Reifschneider A
Year: 2022
Journal: EMBO J
Title: Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency.
Volume: 41
Issue: 4
Pages: e109108
Publication
First Author: He L
Year: 2022
Journal: Transl Psychiatry
Title: Nrf2 regulates the arginase 1<sup>+</sup> microglia phenotype through the initiation of TREM2 transcription, ameliorating depression-like behavior in mice.
Volume: 12
Issue: 1
Pages: 459
Publication
First Author: Sheng L
Year: 2019
Journal: FASEB J
Title: Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP/PS1 mice.
Volume: 33
Issue: 9
Pages: 10425-10442
Publication
First Author: Wang S
Year: 2022
Journal: Cell
Title: TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways.
Volume: 185
Issue: 22
Pages: 4153-4169.e19
Publication  
First Author: Ellwanger DC
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease.
Volume: 118
Issue: 3
Publication  
First Author: von Saucken VE
Year: 2020
Journal: Neurobiol Dis
Title: The effect of amyloid on microglia-neuron interactions before plaque onset occurs independently of TREM2 in a mouse model of Alzheimer's disease.
Volume: 145
Pages: 105072
Publication
First Author: Meilandt WJ
Year: 2020
Journal: J Neurosci
Title: Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model.
Volume: 40
Issue: 9
Pages: 1956-1974
Publication  
First Author: Castranio EL
Year: 2017
Journal: Neurobiol Dis
Title: Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury.
Volume: 105
Pages: 1-14
Publication
First Author: Zhu C
Year: 2015
Journal: Neurobiol Aging
Title: Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains.
Volume: 36
Issue: 5
Pages: 1994-2003
Publication
First Author: Dejanovic B
Year: 2022
Journal: Nat Aging
Title: Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models.
Volume: 2
Issue: 9
Pages: 837-850
Publication
First Author: Zhou Y
Year: 2020
Journal: Nat Med
Title: Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease.
Volume: 26
Issue: 1
Pages: 131-142
Publication
First Author: Zhang K
Year: 2023
Journal: Nat Metab
Title: TREM2(hi) resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis.
Volume: 5
Issue: 1
Pages: 129-146
Publication
First Author: Lee SH
Year: 2021
Journal: Cell Rep
Title: TREM2-independent oligodendrocyte, astrocyte, and T cell responses to tau and amyloid pathology in mouse models of Alzheimer disease.
Volume: 37
Issue: 13
Pages: 110158
Publication
First Author: Takahashi K
Year: 2005
Journal: J Exp Med
Title: Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2.
Volume: 201
Issue: 4
Pages: 647-57
Publication  
First Author: Qu W
Year: 2018
Journal: Front Immunol
Title: Triggering Receptors Expressed on Myeloid Cells 2 Promotes Corneal Resistance Against Pseudomonas aeruginosa by Inhibiting Caspase-1-Dependent Pyroptosis.
Volume: 9
Pages: 1121
Publication
First Author: Dong Y
Year: 2021
Journal: Nat Neurosci
Title: Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia.
Volume: 24
Issue: 4
Pages: 489-503
Publication
First Author: Das M
Year: 2021
Journal: iScience
Title: Interdependence of neural network dysfunction and microglial alterations in Alzheimer's disease-related models.
Volume: 24
Issue: 11
Pages: 103245
Publication
First Author: Jaitin DA
Year: 2019
Journal: Cell
Title: Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner.
Volume: 178
Issue: 3
Pages: 686-698.e14
Publication
First Author: Sudom A
Year: 2018
Journal: J Biol Chem
Title: Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.
Volume: 293
Issue: 32
Pages: 12634-12646
Publication  
First Author: Ulrich JD
Year: 2014
Journal: Mol Neurodegener
Title: Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2.
Volume: 9
Pages: 20
Publication  
First Author: Vilalta A
Year: 2021
Journal: J Biol Chem
Title: Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation.
Volume: 296
Pages: 100631
Publication      
First Author: Kang SS
Year: 2017
Journal: Hum Mol Genet
Title: Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal.
Publication
First Author: Kawabori M
Year: 2015
Journal: J Neurosci
Title: Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke.
Volume: 35
Issue: 8
Pages: 3384-96
Publication  
First Author: Ye H
Year: 2021
Journal: Mol Cell Endocrinol
Title: Triggering receptor expressed on myeloid Cells-2 (TREM2) inhibits steroidogenesis in adrenocortical cell by macrophage-derived exosomes in lipopolysaccharide-induced septic shock.
Volume: 525
Pages: 111178
Publication  
First Author: Duwat C
Year: 2023
Journal: Neurobiol Dis
Title: Development of an AAV-based model of tauopathy targeting retinal ganglion cells and the mouse visual pathway to study the role of microglia in Tau pathology.
Volume: 181
Pages: 106116
Publication  
First Author: Zhong L
Year: 2017
Journal: Front Aging Neurosci
Title: TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway.
Volume: 9
Pages: 204
Publication
First Author: Cheng Q
Year: 2018
Journal: J Biol Chem
Title: TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function.
Volume: 293
Issue: 32
Pages: 12620-12633
Publication
First Author: Saber M
Year: 2017
Journal: J Neurotrauma
Title: Triggering Receptor Expressed on Myeloid Cells 2 Deficiency Alters Acute Macrophage Distribution and Improves Recovery after Traumatic Brain Injury.
Volume: 34
Issue: 2
Pages: 423-435
Publication
First Author: Atagi Y
Year: 2015
Journal: J Biol Chem
Title: Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).
Volume: 290
Issue: 43
Pages: 26043-50
Publication  
First Author: Zheng H
Year: 2016
Journal: Neurobiol Aging
Title: Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation.
Volume: 42
Pages: 132-41
Publication  
First Author: Lessard CB
Year: 2018
Journal: EMBO Mol Med
Title: High-affinity interactions and signal transduction between Aβ oligomers and TREM2.
Volume: 10
Issue: 11
Publication
First Author: Jiang T
Year: 2014
Journal: Neurobiol Aging
Title: Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice.
Volume: 35
Issue: 6
Pages: 1243-51
Publication
First Author: Park M
Year: 2015
Journal: Diabetes
Title: Triggering receptor expressed on myeloid cells 2 (TREM2) promotes adipogenesis and diet-induced obesity.
Volume: 64
Issue: 1
Pages: 117-27
Publication
First Author: Charles JF
Year: 2008
Journal: Infect Immun
Title: The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12.
Volume: 76
Issue: 6
Pages: 2439-47
Publication
First Author: Gratuze M
Year: 2023
Journal: Neuron
Title: TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4.
Volume: 111
Issue: 2
Pages: 202-219.e7
Publication
First Author: Krasemann S
Year: 2017
Journal: Immunity
Title: The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.
Volume: 47
Issue: 3
Pages: 566-581.e9
Publication  
First Author: Gratuze M
Year: 2021
Journal: J Exp Med
Title: Activated microglia mitigate Aβ-associated tau seeding and spreading.
Volume: 218
Issue: 8
Publication
First Author: Rong Z
Year: 2020
Journal: FASEB J
Title: Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ42 in triggering receptor expressed on myeloid cells 2 loss-of-function murine models.
Volume: 34
Issue: 8
Pages: 10984-10997
Publication
First Author: Sayed FA
Year: 2021
Journal: Sci Transl Med
Title: AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.
Volume: 13
Issue: 622
Pages: eabe3947
Publication  
First Author: Cheng B
Year: 2021
Journal: Front Immunol
Title: Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Interacts With Colony-Stimulating Factor 1 Receptor (CSF1R) but Is Not Necessary for CSF1/CSF1R-Mediated Microglial Survival.
Volume: 12
Pages: 633796
Publication  
First Author: Belloli S
Year: 2017
Journal: Neurobiol Aging
Title: Early upregulation of 18-kDa translocator protein in response to acute neurodegenerative damage in TREM2-deficient mice.
Volume: 53
Pages: 159-168
Publication
First Author: Zhou J
Year: 2019
Journal: Neurochem Res
Title: Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer's Disease and Systemic Inflammation.
Volume: 44
Issue: 5
Pages: 1138-1151
Publication
First Author: Sieber MW
Year: 2013
Journal: PLoS One
Title: Attenuated inflammatory response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke.
Volume: 8
Issue: 1
Pages: e52982
Publication  
First Author: Hoogland ICM
Year: 2022
Journal: Neurosci Lett
Title: Microglial response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice after systemic stimulation with Escherichia coli.
Volume: 790
Pages: 136894
Publication
First Author: Essex AL
Year: 2022
Journal: J Bone Miner Res
Title: Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) R47H Variant Causes Distinct Age- and Sex-Dependent Musculoskeletal Alterations in Mice.
Volume: 37
Issue: 7
Pages: 1366-1381
Publication
First Author: Zhong L
Year: 2018
Journal: Mol Neurodegener
Title: Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2).
Volume: 13
Issue: 1
Pages: 15
Publication
First Author: Zhang P
Year: 2022
Journal: Cell Metab
Title: Neuregulin 4 suppresses NASH-HCC development by restraining tumor-prone liver microenvironment.
Volume: 34
Issue: 9
Pages: 1359-1376.e7
Publication
First Author: McQuade A
Year: 2020
Journal: Nat Commun
Title: Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease.
Volume: 11
Issue: 1
Pages: 5370
Publication  
First Author: Zarb Y
Year: 2021
Journal: Sci Adv
Title: Microglia control small vessel calcification via TREM2.
Volume: 7
Issue: 9
Publication
First Author: Fitz NF
Year: 2021
Journal: Nat Commun
Title: Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer's disease.
Volume: 12
Issue: 1
Pages: 3416
Publication
First Author: Anderson SR
Year: 2019
Journal: Cell Rep
Title: Developmental Apoptosis Promotes a Disease-Related Gene Signature and Independence from CSF1R Signaling in Retinal Microglia.
Volume: 27
Issue: 7
Pages: 2002-2013.e5
Publication
First Author: Wang Y
Year: 2016
Journal: J Exp Med
Title: TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques.
Volume: 213
Issue: 5
Pages: 667-75
Publication
First Author: Gratuze M
Year: 2020
Journal: J Clin Invest
Title: Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration.
Volume: 130
Issue: 9
Pages: 4954-4968
Publication  
First Author: Katsumoto A
Year: 2022
Journal: Front Immunol
Title: Triggering receptor expressed on myeloid cells 2 deficiency exacerbates injury-induced inflammation in a mouse model of tauopathy.
Volume: 13
Pages: 978423
Publication
First Author: Koth LL
Year: 2010
Journal: J Immunol
Title: DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2.
Volume: 184
Issue: 11
Pages: 6522-8
Publication
First Author: Tran KM
Year: 2023
Journal: Mol Neurodegener
Title: A Trem2(R47H) mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques.
Volume: 18
Issue: 1
Pages: 12
Publication
First Author: Peng Q
Year: 2010
Journal: Sci Signal
Title: TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.
Volume: 3
Issue: 122
Pages: ra38
Publication
First Author: Humphrey MB
Year: 2006
Journal: J Bone Miner Res
Title: TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function.
Volume: 21
Issue: 2
Pages: 237-45
Publication
First Author: Kobayashi M
Year: 2016
Journal: J Neurosci
Title: TREM2/DAP12 Signal Elicits Proinflammatory Response in Microglia and Exacerbates Neuropathic Pain.
Volume: 36
Issue: 43
Pages: 11138-11150
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Daws MR
Year: 2001
Journal: Eur J Immunol
Title: Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family.
Volume: 31
Issue: 3
Pages: 783-91
Publication
First Author: Mlodzianoski MJ
Year: 2018
Journal: Nat Methods
Title: Active PSF shaping and adaptive optics enable volumetric localization microscopy through brain sections.
Volume: 15
Issue: 8
Pages: 583-586
Publication
First Author: Hommes TJ
Year: 2015
Journal: Am J Respir Cell Mol Biol
Title: Role of triggering receptor expressed on myeloid cells-1/3 in Klebsiella-derived pneumosepsis.
Volume: 53
Issue: 5
Pages: 647-55
Publication
First Author: Keren-Shaul H
Year: 2017
Journal: Cell
Title: A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.
Volume: 169
Issue: 7
Pages: 1276-1290.e17
Publication  
First Author: Coelho I
Year: 2020
Journal: Front Immunol
Title: Trem-2 Promotes Emergence of Restorative Macrophages and Endothelial Cells During Recovery From Hepatic Tissue Damage.
Volume: 11
Pages: 616044
Publication
First Author: Beckmann N
Year: 2018
Journal: Acta Neuropathol Commun
Title: Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945.
Volume: 6
Issue: 1
Pages: 9
Publication
First Author: Floyd HS
Year: 2006
Journal: Mol Carcinog
Title: Genetic and epigenetic alterations in lung tumors from bitransgenic Ki-rasG12C expressing mice.
Volume: 45
Issue: 7
Pages: 506-17
Publication
First Author: Quan DN
Year: 2008
Journal: Mucosal Immunol
Title: TREM-2 binds to lipooligosaccharides of Neisseria gonorrhoeae and is expressed on reproductive tract epithelial cells.
Volume: 1
Issue: 3
Pages: 229-38
Publication
First Author: Daws MR
Year: 2003
Journal: J Immunol
Title: Pattern recognition by TREM-2: binding of anionic ligands.
Volume: 171
Issue: 2
Pages: 594-9
Publication
First Author: Zhang J
Year: 2020
Journal: J Neuroinflammation
Title: TREM-2-p38 MAPK signaling regulates neuroinflammation during chronic cerebral hypoperfusion combined with diabetes mellitus.
Volume: 17
Issue: 1
Pages: 2
Publication
First Author: Prada I
Year: 2006
Journal: Neuroscience
Title: Triggering receptor expressed in myeloid cells 2 (TREM2) trafficking in microglial cells: continuous shuttling to and from the plasma membrane regulated by cell stimulation.
Volume: 140
Issue: 4
Pages: 1139-48
Publication
First Author: Piccio L
Year: 2007
Journal: Eur J Immunol
Title: Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis.
Volume: 37
Issue: 5
Pages: 1290-301
Publication
First Author: Chang JH
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Enhanced inhibitory effects of a novel CpG motif on osteoclast differentiation via TREM-2 down-regulation.
Volume: 389
Issue: 1
Pages: 28-33
Publication
First Author: Sun M
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: TREM-2 promotes host resistance against Pseudomonas aeruginosa infection by suppressing corneal inflammation via a PI3K/Akt signaling pathway.
Volume: 54
Issue: 5
Pages: 3451-62
Publication
First Author: Wu Y
Year: 2021
Journal: Sci Adv
Title: TREM-2 is a sensor and activator of T cell response in SARS-CoV-2 infection.
Volume: 7
Issue: 50
Pages: eabi6802
GXD Expression      
Probe: MGI:3838121
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689422
Stage: TS22
Assay Id: MGI:3838123
Age: embryonic day 14.0
Specimen Label: E14
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3838121
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:3838123
Age: embryonic day 16.0
Specimen Label: E16
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3838121
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:3838123
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3838121
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:3838123
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3838121
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3838123
Age: postnatal day 5
Specimen Label: P5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3838121
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3838123
Age: postnatal day 15
Specimen Label: P15
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3838121
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3838123
Age: postnatal day 20
Specimen Label: P20
Detected: true
Specimen Num: 7