NFAM1 is a cell surface molecule belonging to the Ig superfamily. It contains an N-terminal signal peptide, an immunoglobin domain in the extracellular region, a transmembrane domain and an ITAM (immunoreceptor tyrosine-based activation motif) in the cytoplasmic tail. NFAM1 activates the calcineurin/NFAT-signaling pathway and the downstream cytokine gene promoters []. It has been shown to modulate B cell signaling through its ITAM, which regulates B cell development [].
