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Search results 201 to 258 out of 258 for Letm1

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Type Details Score
GXD Expression
GXD Expression
   
Probe: MGI:6176385
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190703
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Letmd1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6176385
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6190703
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Letmd1
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6176385
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6190703
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Letmd1
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:6176385
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6190703
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Letmd1
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:6176385
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190703
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Letmd1
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6176385
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190703
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Letmd1
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6176385
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190703
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Letmd1
Detected: true
Specimen Num: 7
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Allele
Letmd1<em2Gpt> | MGI:7301601
Name: LETM1 domain containing 1; endonuclease-mediated mutation 2, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Letmd1<Gt(OST279538)Lex> | MGI:4261833
 
Name: LETM1 domain containing 1; gene trap OST279538, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Letmd1<em1Etch> | MGI:7388301
Name: LETM1 domain containing 1; endonuclease-mediated mutation 1, Edward T Chouchani
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Letmd1<em1Gpt> | MGI:7301600
Name: LETM1 domain containing 1; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Publication
37353518 | J:337469
First Author: Park A
Year: 2023
Journal: Nat Commun
Title: Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice.
Volume: 14
Issue: 1
Pages: 3746
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Allele
Letmd1<tm1a(EUCOMM)Hmgu> | MGI:4843873
Name: LETM1 domain containing 1; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Letmd1<Gt(IST13629D5)Tigm> | MGI:5178070
 
Name: LETM1 domain containing 1; gene trap IST13629D5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Letmd1<em1Mbp> | MGI:6887450
Name: LETM1 domain containing 1; endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Letmd1<tm1e(EUCOMM)Hmgu> | MGI:4843882
Name: LETM1 domain containing 1; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Letmd1<em1(IMPC)Kmpc> | MGI:6336122
Name: LETM1 domain containing 1; endonuclease-mediated mutation 1, Korea Mouse Phenotyping Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Letmd1<tm1c(EUCOMM)Hmgu> | MGI:7495511
Name: LETM1 domain containing 1; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready
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Allele
Letmd1<Gt(IST13947B3)Tigm> | MGI:5195768
 
Name: LETM1 domain containing 1; gene trap IST13947B3, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Publication
12879013 | -
First Author: Ko J
Year: 2003
Journal: Oncogene
Title: Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilization.
Volume: 22
Issue: 30
Pages: 4679-89
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Strain
MGI:6887645 | C57BL/6J-Letmd1<em1Mbp>
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:6424128 | C57BL/6N-Letmd1<em1(IMPC)Kmpc>/Kmpc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:7471609 | C57BL/6NTac-Letmd1<em1(IMPC)Kmpc>/Kmpc
Attribute String: coisogenic
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Genotype
Genotype
Symbol: Letmd1/Letmd1
Background: C57BL/6J-Letmd1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Letmd1/Letmd1
Background: C57BL/6NTac-Letmd1/Kmpc
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Letmd1/Letmd1
Background: involves: C57BL/6N
Zygosity: hm
Has Mutant Allele: true
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Publication
10071211 | -
First Author: Caggese C
Year: 1999
Journal: Mol Gen Genet
Title: Identification of nuclear genes encoding mitochondrial proteins: isolation of a collection of D. melanogaster cDNAs homologous to sequences in the Human Gene Index database.
Volume: 261
Issue: 1
Pages: 64-70
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Publication
15904662 | -
First Author: Froschauer E
Year: 2005
Journal: Biochim Biophys Acta
Title: Electroneutral K+/H+ exchange in mitochondrial membrane vesicles involves Yol027/Letm1 proteins.
Volume: 1711
Issue: 1
Pages: 41-8
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Publication
21718401 | -
First Author: Lupo D
Year: 2011
Journal: Traffic
Title: Mdm38 is a 14-3-3-like receptor and associates with the protein synthesis machinery at the inner mitochondrial membrane.
Volume: 12
Issue: 10
Pages: 1457-66
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Protein Domain
IPR033122 | LETM1-like_RBD
Type: Domain
Description: Mitochondrial ribosomes synthesise core subunits of the inner membranerespiratory chain complexes. In mitochondria, ribosomes are mainly membraneassociated and translation is tightly coupled to the inner mitochondrialmembrane. Mdm38/Letm1 is a conserved membrane receptor for mitochondrialribosomes and specifically involved in respiratory chain biogenesis.These proteins play a role in potassium and hydrogen ion exchange [, ]. Some features found in LETM1, such as a transmembrane domain and a CK2 and PKC phosphorylation site [], are relatively conserved throughout the family. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans [].This entry represents the Letm1 ribosome-binding domain (RBD) of Letm1 from animals and MDM38 from yeast. This domain is necessary and sufficient forinteraction with mitochondrial ribosomes. It exhibits a predominantly α-helical compact fold and contains extended, highly chargedsurface patches. The conserved regions most probably represent interactionsites for ribosomal RNA or protein subunits, or for proteins involved inmitochondrial protein biogenesis [, ].
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Publication
20427570 | -
First Author: Bauerschmitt H
Year: 2010
Journal: Mol Biol Cell
Title: Ribosome-binding proteins Mdm38 and Mba1 display overlapping functions for regulation of mitochondrial translation.
Volume: 21
Issue: 12
Pages: 1937-44
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Publication
15138253 | -
First Author: Nowikovsky K
Year: 2004
Journal: J Biol Chem
Title: The LETM1/YOL027 gene family encodes a factor of the mitochondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome.
Volume: 279
Issue: 29
Pages: 30307-15
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Protein Domain
IPR044202 | LETM1/MDM38-like
Type: Family
Description: This family represents a group of LETM1-like mitochondrial inner membrane proteins, including LETM1/LETM2 from mammals and YLH47/MDM38 from yeastsLETM1 is a proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion []. LETM2 is preferentially expressed in testis and sperm. In humans, deletion of LETM1 causes Wolf-Hirschhorn syndrome []. MDM38 is involved in potassium homeostasis []and, with MBA1, it plays a role in ribosomal translation and protein insertion into the inner membrane [].
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Protein
Q9Z2I0
Organism: Mus musculus/domesticus
Length: 738  
Fragment?: false
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Publication
20824095 | J:165023
 
First Author: Hwang SK
Year: 2010
Journal: PLoS One
Title: Suppression of lung tumorigenesis by leucine zipper/EF hand-containing transmembrane-1.
Volume: 5
Issue: 9
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
- | J:66660
       
First Author: Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration
Year: 2001
Title: LocusLink Collaboration
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:73796
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
11042159 | J:68323
First Author: Carninci P
Year: 2000
Journal: Genome Res
Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Volume: 10
Issue: 10
Pages: 1617-30
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Publication
10349636 | J:80645
 
First Author: Carninci P
Year: 1999
Journal: Methods Enzymol
Title: High-efficiency full-length cDNA cloning.
Volume: 303
Pages: 19-44
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Publication
11076861 | J:68324
First Author: Shibata K
Year: 2000
Journal: Genome Res
Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Volume: 10
Issue: 11
Pages: 1757-71
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Publication
16141073 | -
First Author: Katayama S
Year: 2005
Journal: Science
Title: Antisense transcription in the mammalian transcriptome.
Volume: 309
Issue: 5740
Pages: 1564-6
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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