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Search results 201 to 220 out of 220 for Rnf4

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0.017s

Type

Details

Score

Publication

26299341 | -

First Author:	Tan B
Year:	2015
Journal:	FEBS Lett
Title:	RNF4 negatively regulates NF-κB signaling by down-regulating TAB2.
Volume:	589
Issue:	19 Pt B
Pages:	2850-8

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Publication

28612051 | -

First Author:	Aguilar-Martinez E
Year:	2016
Journal:	Wellcome Open Res
Title:	RNF4 interacts with multiSUMOylated ETV4.
Volume:	1

Pages:	3

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Publication

10713105 | J:69260

First Author:	Fedele M
Year:	2000
Journal:	J Biol Chem
Title:	A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor.
Volume:	275
Issue:	11
Pages:	7894-901

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Publication

18408734 | -

First Author:	Tatham MH
Year:	2008
Journal:	Nat Cell Biol
Title:	RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation.
Volume:	10
Issue:	5
Pages:	538-46

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Interaction Experiment

Liew CW (2010)

Description:

RING domain dimerization is essential for RNF4 function.

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Publication

12874792 | -

First Author:	Pero R
Year:	2003
Journal:	Mol Reprod Dev
Title:	Translational regulation of a novel testis-specific RNF4 transcript.
Volume:	66
Issue:	1
Pages:	1-7

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Interaction Experiment

Liu Y (2017)

Description:

Manipulating PML SUMOylation via Silencing UBC9 and RNF4 Regulates Cardiac Fibrosis.

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Publication

28143738 | -

First Author:	Liu Y
Year:	2017
Journal:	Mol Ther
Title:	Manipulating PML SUMOylation via Silencing UBC9 and RNF4 Regulates Cardiac Fibrosis.
Volume:	25
Issue:	3
Pages:	666-678

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GO Term

GO:0033768 | SUMO-targeted ubiquitin ligase complex

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Publication

22842904 | -

First Author:	Plechanovová A
Year:	2012
Journal:	Nature
Title:	Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis.
Volume:	489
Issue:	7414
Pages:	115-20

•

Publication

26450775 | -

First Author:	Her J
Year:	2015
Journal:	FEBS Lett
Title:	PIAS1-mediated sumoylation promotes STUbL-dependent proteasomal degradation of the human telomeric protein TRF2.
Volume:	589
Issue:	21
Pages:	3277-86

•

Publication

25969536 | -

First Author:	Hendriks IA
Year:	2015
Journal:	J Biol Chem
Title:	Ubiquitin-specific Protease 11 (USP11) Deubiquitinates Hybrid Small Ubiquitin-like Modifier (SUMO)-Ubiquitin Chains to Counteract RING Finger Protein 4 (RNF4).
Volume:	290
Issue:	25
Pages:	15526-37

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Publication

26148049 | -

First Author:	Branigan E
Year:	2015
Journal:	Nat Struct Mol Biol
Title:	Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains.
Volume:	22
Issue:	8
Pages:	597-602

•

Protein Domain

IPR043295 | RING-HC_RNF4

Type:

Domain

Description:

RNF4 is a SUMO-targeted E3 ubiquitin-protein ligase with a pivotal function in the DNA damage response (DDR) through interacting with the deubiquitinating enzyme ubiquitin-specific protease 11 (USP11), a known DDR-component, and further facilitating DNA repair []. It plays a novel role in preventing the loss of intact chromosomes and ensures the maintenance of chromosome integrity. Moreover, RNF4 is responsible for the UbcH5A-catalyzed formation of K48 chains that target SUMO-modified promyelocytic leukemia (PML) protein for proteasomal degradation in response to arsenic treatment []. It also interacts with telomeric repeat binding factor 2 (TRF2) in a small ubiquitin-like modifiers (SUMO)-dependent manner and preferentially targets SUMO-conjugated TRF2 for ubiquitination through SUMO-interacting motifs (SIMs) []. Furthermore, RNF4 can form a complex with a Ubc13-ubiquitin conjugate and Ube2V2. It catalyzes K63-linked polyubiquitination by the Ube2V2-Ubc13 (ubiquitin-loaded) complex []. Meanwhile, RNF4 negatively regulates nuclear factor kappa B (NF-kappaB) signaling by down-regulating transforming growth factor beta (TGF-beta)-activated kinase 1 (TAK1)-TAK1-binding protein2 (TAB2) []. RNF4 contains four SIMs followed by a C3HC4-type RING-HC finger at the C-terminal [].This entry represents the C3HC4-type RING-HC finger.

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Protein

Q3TXE6

Organism:	Mus musculus/domesticus
Length:	194
Fragment?:	false

•

Protein

Q3ULB8

Organism:	Mus musculus/domesticus
Length:	202
Fragment?:	false

•

Publication

17242355 | -

First Author:	Villén J
Year:	2007
Journal:	Proc Natl Acad Sci U S A
Title:	Large-scale phosphorylation analysis of mouse liver.
Volume:	104
Issue:	5
Pages:	1488-93

•

Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

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Publication

21183079 | J:292518

First Author:	Huttlin EL
Year:	2010
Journal:	Cell
Title:	A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume:	143
Issue:	7
Pages:	1174-89

•

Publication

19468303 | -

First Author:	Church DM
Year:	2009
Journal:	PLoS Biol
Title:	Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume:	7
Issue:	5
Pages:	e1000112

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