Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:3526169 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-02-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3747020 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:3526175 |
Age: |
embryonic day 12.5 |
Image: |
2C |
|
Specimen Label: |
2C |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3526169 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-02-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3747022 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:3526175 |
Age: |
embryonic day 14.5 |
Image: |
2D |
|
Specimen Label: |
2D |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3526169 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-02-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3747120 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:3526175 |
Age: |
embryonic day 12.5 |
Image: |
2C |
|
Specimen Label: |
2C |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3526169 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-02-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3747122 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:3526175 |
Age: |
embryonic day 14.5 |
Image: |
2D |
|
Specimen Label: |
2D |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu Z |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
Fscn1 is required for the trafficking of TGF-β family type I receptors during endoderm formation. |
Volume: |
7 |
|
Pages: |
12603 |
|
•
•
•
•
•
|
Publication |
First Author: |
Edwards RA |
Year: |
1995 |
Journal: |
J Biol Chem |
Title: |
Cloning and expression of a murine fascin homolog from mouse brain. |
Volume: |
270 |
Issue: |
18 |
Pages: |
10764-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li X |
Year: |
2012 |
Journal: |
Oncogene |
Title: |
Semaphorin 5A and plexin-B3 regulate human glioma cell motility and morphology through Rac1 and the actin cytoskeleton. |
Volume: |
31 |
Issue: |
5 |
Pages: |
595-610 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ma Y |
Year: |
2013 |
Journal: |
Development |
Title: |
Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation. |
Volume: |
140 |
Issue: |
10 |
Pages: |
2203-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang J |
Year: |
2024 |
Journal: |
J Neuroinflammation |
Title: |
Fascin-1 limits myosin activity in microglia to control mechanical characterization of the injured spinal cord. |
Volume: |
21 |
Issue: |
1 |
Pages: |
88 |
|
•
•
•
•
•
|
Publication |
First Author: |
De Arcangelis A |
Year: |
2004 |
Journal: |
Gene Expr Patterns |
Title: |
Expression of fascin-1, the gene encoding the actin-bundling protein fascin-1, during mouse embryogenesis. |
Volume: |
4 |
Issue: |
6 |
Pages: |
637-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blumenthal D |
Year: |
2020 |
Journal: |
Elife |
Title: |
Mouse T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex. |
Volume: |
9 |
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|
•
•
•
•
•
|
Publication |
First Author: |
Ma Y |
Year: |
2013 |
Journal: |
Biol Open |
Title: |
Fascin 1 is dispensable for developmental and tumour angiogenesis. |
Volume: |
2 |
Issue: |
11 |
Pages: |
1187-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamakita Y |
Year: |
2009 |
Journal: |
Cell Motil Cytoskeleton |
Title: |
Fascin1 is dispensable for mouse development but is favorable for neonatal survival. |
Volume: |
66 |
Issue: |
8 |
Pages: |
524-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suzuki S |
Year: |
2015 |
Journal: |
Exp Anim |
Title: |
Quantitative trait loci on chromosome 5 for susceptibility to frequency-specific effects on hearing in DBA/2J mice. |
Volume: |
64 |
Issue: |
3 |
Pages: |
241-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsumura F |
Year: |
2021 |
Journal: |
J Immunol |
Title: |
Investigation of Fascin1, a Marker of Mature Dendritic Cells, Reveals a New Role for IL-6 Signaling in CCR7-Mediated Chemotaxis. |
Volume: |
207 |
Issue: |
3 |
Pages: |
938-949 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim JK |
Year: |
2011 |
Journal: |
J Immunol |
Title: |
A novel pathway responsible for lipopolysaccharide-induced translational regulation of TNF-α and IL-6 expression involves protein kinase C and fascin. |
Volume: |
187 |
Issue: |
12 |
Pages: |
6327-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wei Z |
Year: |
2014 |
Journal: |
J Neurochem |
Title: |
Rufy3, a protein specifically expressed in neurons, interacts with actin-bundling protein Fascin to control the growth of axons. |
Volume: |
130 |
Issue: |
5 |
Pages: |
678-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mejillano MR |
Year: |
2004 |
Journal: |
Cell |
Title: |
Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end. |
Volume: |
118 |
Issue: |
3 |
Pages: |
363-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miao Q |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair. |
Volume: |
10 |
Issue: |
1 |
Pages: |
4042 |
|
•
•
•
•
•
|
Publication |
First Author: |
Neidhardt LM |
Year: |
1997 |
Journal: |
Dev Genes Evol |
Title: |
A mouse gene of the paired-related homeobox class expressed in the caudal somite compartment and in the developing vertebral column, kidney and nervous system. |
Volume: |
207 |
Issue: |
5 |
Pages: |
330-339 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schwartz B |
Year: |
2014 |
Journal: |
Mech Dev |
Title: |
SRF is essential for mesodermal cell migration during elongation of the embryonic body axis. |
Volume: |
133 |
|
Pages: |
23-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wertz K |
Year: |
2000 |
Journal: |
Mech Dev |
Title: |
Large-scale screen for genes involved in gonad development. |
Volume: |
98 |
Issue: |
1-2 |
Pages: |
51-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Werner HB |
Year: |
2007 |
Journal: |
J Neurosci |
Title: |
Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. |
Volume: |
27 |
Issue: |
29 |
Pages: |
7717-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brady KP |
Year: |
1997 |
Journal: |
Genome Res |
Title: |
Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. |
Volume: |
7 |
Issue: |
11 |
Pages: |
1085-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
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•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
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•
•
•
•
•
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Publication |
First Author: |
Koscielny G |
Year: |
2014 |
Journal: |
Nucleic Acids Res |
Title: |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
Volume: |
42 |
Issue: |
Database issue |
Pages: |
D802-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data |
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|
•
•
•
•
•
|
Publication |
First Author: |
International Knockout Mouse Consortium |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
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•
•
•
•
•
|
Publication |
First Author: |
Lennon G |
Year: |
1999 |
Journal: |
Database Download |
Title: |
WashU-HHMI Mouse EST Project |
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•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
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•
•
•
•
•
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Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
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•
•
•
•
•
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Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
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•
•
•
•
•
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Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
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•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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•
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•
•
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Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
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•
•
•
•
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Publication |
First Author: |
GOA curators |
Year: |
2016 |
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Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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•
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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•
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Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
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Pages: |
e86 |
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•
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Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
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Issue: |
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Pages: |
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Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
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Issue: |
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Pages: |
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Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
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Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
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Issue: |
8002 |
Pages: |
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Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
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•
•
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•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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Publication |
First Author: |
GemPharmatech |
Year: |
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Title: |
GemPharmatech Website. |
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Publication |
First Author: |
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Year: |
2011 |
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Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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Publication |
First Author: |
Okazaki Y |
Year: |
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Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
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Issue: |
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Pages: |
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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•
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
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Pages: |
e1000582 |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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Publication |
First Author: |
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Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
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Journal: |
Database Release |
Title: |
Entrez Gene Load |
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•
•
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•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
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Publication |
First Author: |
Hashimoto Y |
Year: |
2005 |
Journal: |
Int J Biochem Cell Biol |
Title: |
Roles of fascin in human carcinoma motility and signaling: prospects for a novel biomarker? |
Volume: |
37 |
Issue: |
9 |
Pages: |
1787-804 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents fascin (FSCN) and its homologues, including FSCN1/2/3 from mammals and protein singed from fruit flies. Fascin is a globular actin cross-linking protein, which functions in forming parallel actin bundles in cell protrusions that are key specialisations of the plasma membrane for environmental guidance and cell migration []. Human FSCN1 organises filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Overexpression of fascin has been linked to a more aggressive clinical course of cancer []. |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE5510 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Cheng Y |
Year: |
2007 |
Journal: |
Mol Cell Biol |
Title: |
Abnormal sperm in mice lacking the Taf7l gene. |
Volume: |
27 |
Issue: |
7 |
Pages: |
2582-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bros M |
Year: |
2011 |
Journal: |
Gene |
Title: |
Differential gene expression analysis identifies murine Cacnb3 as strongly upregulated in distinct dendritic cell populations upon stimulation. |
Volume: |
472 |
Issue: |
1-2 |
Pages: |
18-27 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
498
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
492
|
Fragment?: |
false |
|
•
•
•
•
•
|