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Search results 101 to 189 out of 189 for Wrn

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Type Details Score
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication
First Author: Wang L
Year: 2000
Journal: Genetics
Title: Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene.
Volume: 154
Issue: 1
Pages: 357-62
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
HT Experiment
Series Id: GSE14549
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Protein
Organism: Mus musculus/domesticus
Length: 1401  
Fragment?: false
Publication
First Author: Si X
Year: 2018
Journal: Int J Biol Sci
Title: Loss of p21 promoted tumorigenesis in the background of telomere dysfunctions induced by TRF2 and Wrn deficiency.
Volume: 14
Issue: 2
Pages: 165-177
Allele
Name: Werner syndrome RecQ like helicase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: transgene insertion 5025, Warren C Ladiges
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Genotype
Symbol: Tg(CAG-WRN*K577M)5025Wcl/?
Background: involves: C3H * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
Publication
First Author: Liu H
Year: 2002
Journal: Nucleic Acids Res
Title: Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation.
Volume: 30
Issue: 11
Pages: 2417-26
Allele
Name: Werner syndrome RecQ like helicase; targeted mutation 1, Philip Leder
Allele Type: Targeted
Attribute String: Null/knockout
Allele
Name: Werner syndrome RecQ like helicase; targeted mutation 1, Leonard Guarente
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Strain
Attribute String: congenic, mutant strain, transgenic
Publication
First Author: Yamamoto ML
Year: 2008
Journal: Mutat Res
Title: Effects of human Werner helicase on intrachromosomal homologous recombination mediated DNA deletions in mice.
Volume: 644
Issue: 1-2
Pages: 11-6
Transgene
Type: transgene
Organism: mouse, laboratory
Genotype
Symbol: Wrn/Wrn
Background: B6.129S6(BKSW)-Wrn
Zygosity: hm
Has Mutant Allele: true
DO Term
Genotype
Symbol: Terc/Terc Wrn/Wrn
Background: involves: 129/Sv * BALB/c * C57BL/6 * SLJ
Zygosity: cx
Has Mutant Allele: true
Allele
Name: telomerase RNA component; targeted mutation 1, Ronald DePinho
Allele Type: Targeted
Attribute String: Null/knockout
Publication
First Author: Gray MD
Year: 1997
Journal: Nat Genet
Title: The Werner syndrome protein is a DNA helicase.
Volume: 17
Issue: 1
Pages: 100-3
Publication
First Author: Yan H
Year: 1998
Journal: Nat Genet
Title: Replication focus-forming activity 1 and the Werner syndrome gene product.
Volume: 19
Issue: 4
Pages: 375-8
Publication
First Author: Suzuki N
Year: 1997
Journal: Nucleic Acids Res
Title: DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system.
Volume: 25
Issue: 15
Pages: 2973-8
Publication
First Author: Pezo V
Year: 2021
Journal: Science
Title: Noncanonical DNA polymerization by aminoadenine-based siphoviruses.
Volume: 372
Issue: 6541
Pages: 520-524
Publication
First Author: Andraos N
Year: 2004
Journal: J Biol Chem
Title: The highly processive DNA polymerase of bacteriophage T5. Role of the unique N and C termini.
Volume: 279
Issue: 48
Pages: 50609-18
Protein Domain
Type: Domain
Description: This entry represents the domain that is responsible for the 3'-5' exonuclease proofreading activity of Escherichia coli DNA polymerase I (polI) and other enzymes which catalyse the hydrolysis of unpaired or mismatched nucleotides. This domain consists of the amino-terminal half of the Klenow fragment in E. coli polI and is also found in the Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (also known as Werner syndrome helicase), focus forming activity 1 protein (FFA-1) and ribonuclease D (RNase D) [].Werner syndrome is a human genetic disorder causing premature ageing; the WRN protein has helicase activity in the 3'-5' direction [, ]. The FFA-1 protein is required for formation of a replication foci and also has helicase activity; it is a homologue of the WRN protein []. RNase D is a 3'-5' exonuclease involved in tRNA processing. Also found in this family is the autoantigen PM/Scl thought to be involved in polymyositis-scleroderma overlap syndrome.This domain is also found in some DNA polymerases from phages, including the DNA polymerase from Escherichia phage T5, exonucleolytic activity [], and the DNA polymerase DpoZ from Acinetobacter phage SH-Ab 15497, which preferentially incorporates the non-canonical base aminoadenine/dZTP instead of adenine into the synthesized DNA [].
Publication
First Author: Ichikawa K
Year: 2002
Journal: Nihon Yakurigaku Zasshi
Title: [Preparation of the gene targeted knockout mice for human premature aging diseases, Werner syndrome, and Rothmund-Thomson syndrome caused by the mutation of DNA helicases].
Volume: 119
Issue: 4
Pages: 219-26
Protein
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 650  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 265  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 650  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: true
Publication
First Author: Cheng WH
Year: 2007
Journal: Exp Gerontol
Title: Werner syndrome protein: functions in the response to DNA damage and replication stress in S-phase.
Volume: 42
Issue: 9
Pages: 871-8
Publication
First Author: Fang EF
Year: 2019
Journal: Nat Commun
Title: NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome.
Volume: 10
Issue: 1
Pages: 5284
Protein Domain
Type: Homologous_superfamily
Description: This superfamily represents the HRDC (helicase and RNaseD C-terminal) domain, which comprises two orthogonally packed α-hairpin subdomains, and is involved in interactions with DNA and protein. The HRDC (helicase and RNaseD C-terminal) domain is found at the C terminus of many RecQ helicases, including the human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN and RecQ-like DNA helicase BLM (previously known as Werner and Bloom syndrome proteins) []. RecQ helicases have been shown to unwind DNA in an ATP-dependent manner. The structure of the HRDC domain consists of a 4-5 helical bundle of two orthogonally packed α-hairpins, and as such it resembles auxiliary domains in bacterial DNA helicases and other proteins that interact with nucleic acids. A positively charged region on the surface of the HRDC domain is able to interact with DNA.The HRDC domain is also present in eukaryotic and archaeal RNA polymerase II subunit RBP4, the N-terminal of which forms a heterodimerisation α-hairpin [, ].
Protein
Organism: Mus musculus/domesticus
Length: 517  
Fragment?: true
Gene
Type: gene
Organism: human
Publication
First Author: Liu Z
Year: 1999
Journal: Structure
Title: The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins.
Volume: 7
Issue: 12
Pages: 1557-66
Publication
First Author: Armache KJ
Year: 2005
Journal: J Biol Chem
Title: Structures of complete RNA polymerase II and its subcomplex, Rpb4/7.
Volume: 280
Issue: 8
Pages: 7131-4
Protein
Organism: Mus musculus/domesticus
Length: 887  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 705  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 887  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 618  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 887  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
Publication
First Author: Morozov V
Year: 1997
Journal: Trends Biochem Sci
Title: A putative nucleic acid-binding domain in Bloom's and Werner's syndrome helicases.
Volume: 22
Issue: 11
Pages: 417-8
Publication
First Author: Ohhata T
Year: 2000
Journal: Gene
Title: Cloning, genomic structure and chromosomal localization of the gene encoding mouse DNA helicase RecQ helicase protein-like 4.
Volume: 261
Issue: 2
Pages: 251-8
Publication
First Author: Pereira M
Year: 2007
Journal: Mech Ageing Dev
Title: Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality.
Volume: 128
Issue: 11-12
Pages: 609-17
Publication
First Author: Paul E
Year: 2009
Journal: Mamm Genome
Title: Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death.
Volume: 20
Issue: 2
Pages: 92-108
Publication  
First Author: Bopp A
Year: 2013
Journal: Cell Death Dis
Title: Rac1 modulates acute and subacute genotoxin-induced hepatic stress responses, fibrosis and liver aging.
Volume: 4
Pages: e558
Publication
First Author: Morales C
Year: 2020
Journal: J Biol Chem
Title: PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection.
Volume: 295
Issue: 1
Pages: 146-157
Publication
First Author: Zhao J
Year: 2019
Journal: Int J Biol Sci
Title: p53 Mutant p53N236S Induces Neural Tube Defects in Female Embryos.
Volume: 15
Issue: 9
Pages: 2006-2015
Publication
First Author: Croteau DL
Year: 2012
Journal: Aging Cell
Title: RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity.
Volume: 11
Issue: 3
Pages: 456-66
Protein
Organism: Mus musculus/domesticus
Length: 72  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 42  
Fragment?: true
Protein Domain
Type: Domain
Description: The HRDC (helicase and RNaseD C-terminal) domain is comprised of two orthogonally packed α-hairpin subdomains, and is involved in interactions with DNA and protein. It has been suggested that this domain plays a role dissolving double Holliday junctions efficiently [].HRDC domains are found at the C terminus of many RecQ helicases, including the human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN and RecQ-like DNA helicase BLM [, ]. RecQ helicases have been shown to unwind DNA in an ATP-dependent manner. The structure of the HRDC domain consists of a 4-5 helical bundle of two orthogonally packed alpha-hairpins, and as such it resembles auxiliary domains in bacterial DNA helicases and other proteins that interact with nucleic acids. A positively charged region on the surface of the HRDC domain is able to interact with DNA.The HRDC domain is also present in eukaryotic and archaeal RNA polymerase II subunit RBP4, the N-terminal of which forms a heterodimerisation α-hairpin [, ].The HRDC domain has a putative role in nucleic acid binding. Mutations in the HRDC domain associated with the human BLM gene result in Bloom Syndrome (BS), an autosomal recessive disorder characterised by proportionate pre- and postnatal growth deficiency; sun-sensitive, telangiectatic, hypo- and hyperpigmented skin; predisposition to malignancy; and chromosomal instability [].
Protein Domain
Type: Homologous_superfamily
Description: The HRDC (helicase and RNaseD C-terminal) domain is comprised of two orthogonally packed α-hairpin subdomains, and is involved in interactions with DNA and protein. It has been suggested that this domain plays a role dissolving double Holliday junctions efficiently [].HRDC domains are found at the C terminus of many RecQ helicases, including the human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN and RecQ-like DNA helicase BLM [, ]. RecQ helicases have been shown to unwind DNA in an ATP-dependent manner. The structure of the HRDC domain consists of a 4-5 helical bundle of two orthogonally packed alpha-hairpins, and as such it resembles auxiliary domains in bacterial DNA helicases and other proteins that interact with nucleic acids. A positively charged region on the surface of the HRDC domain is able to interact with DNA.The HRDC domain is also present in eukaryotic and archaeal RNA polymerase II subunit RBP4, the N-terminal of which forms a heterodimerisation α-hairpin [, ].The HRDC domain has a putative role in nucleic acid binding. Mutations in the HRDC domain associated with the human BLM gene result in Bloom Syndrome (BS), an autosomal recessive disorder characterised by proportionate pre- and postnatal growth deficiency; sun-sensitive, telangiectatic, hypo- and hyperpigmented skin; predisposition to malignancy; and chromosomal instability [].
Publication
First Author: Newman JA
Year: 2015
Journal: Nucleic Acids Res
Title: Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes.
Volume: 43
Issue: 10
Pages: 5221-35
Protein
Organism: Mus musculus/domesticus
Length: 497  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 436  
Fragment?: true
Publication
First Author: Todone F
Year: 2001
Journal: Mol Cell
Title: Structure of an archaeal homolog of the eukaryotic RNA polymerase II RPB4/RPB7 complex.
Volume: 8
Issue: 5
Pages: 1137-43
Protein
Organism: Mus musculus/domesticus
Length: 789  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1416  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1419  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1158  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: false