Proteins in this family contain a highly conserved tripeptide motif LYR close to the N terminus. Human LYR motif-containing protein 1 (LYRM1) is highly expressed in omental adipose tissue of obese subjects, promotes preadipocyte proliferation, and inhibits apoptosis of preadipocytes [].
LYR motif-containing protein 1 (LYRM1) may promote cell proliferation and inhibition of apoptosis of preadipocytes []. Overexpression of the human LYRM1 causes mitochondrial dysfunction and induces insulin resistance in 3T3-L1 adipocytes []. LYRM1 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N terminus.
