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Search results 601 to 678 out of 678 for Cxcl10

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Type Details Score
Publication
29112952 | J:253691
First Author: Ivin M
Year: 2017
Journal: PLoS Pathog
Title: Natural killer cell-intrinsic type I IFN signaling controls Klebsiella pneumoniae growth during lung infection.
Volume: 13
Issue: 11
Pages: e1006696
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Publication
25986989 | J:253877
First Author: Manning BM
Year: 2015
Journal: Biochim Biophys Acta
Title: Single-cell analysis of mast cell degranulation induced by airway smooth muscle-secreted chemokines.
Volume: 1850
Issue: 9
Pages: 1862-8
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Publication
28397794 | J:255749
 
First Author: Losada-Barragán M
Year: 2017
Journal: Sci Rep
Title: Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum.
Volume: 7
Pages: 45991
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Publication
28234357 | J:268269
First Author: Garg AD
Year: 2017
Journal: Cell Death Differ
Title: Pathogen response-like recruitment and activation of neutrophils by sterile immunogenic dying cells drives neutrophil-mediated residual cell killing.
Volume: 24
Issue: 5
Pages: 832-843
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Publication
30548340 | J:272500
First Author: Recasens M
Year: 2019
Journal: Glia
Title: Astrocyte-targeted IL-10 production decreases proliferation and induces a downregulation of activated microglia/macrophages after PPT.
Volume: 67
Issue: 4
Pages: 741-758
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Publication
30461288 | J:269588
First Author: Britto CJ
Year: 2019
Journal: Am J Physiol Lung Cell Mol Physiol
Title: BPIFA1 regulates lung neutrophil recruitment and interferon signaling during acute inflammation.
Volume: 316
Issue: 2
Pages: L321-L333
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Publication
31337508 | J:295743
 
First Author: Tatsumi K
Year: 2019
Journal: Cell Immunol
Title: Protease-activated receptor 4 protects mice from Coxsackievirus B3 and H1N1 influenza A virus infection.
Volume: 344
Pages: 103949
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Publication
32943658 | J:296389
First Author: Shono K
Year: 2020
Journal: Sci Rep
Title: Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 axes contributes to antitumor effects in a mouse model of malignant glioma.
Volume: 10
Issue: 1
Pages: 15286
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Publication
33689775 | J:303950
 
First Author: Yan Y
Year: 2021
Journal: Cancer Lett
Title: Interferon regulatory factor 1(IRF-1) activates anti-tumor immunity via CXCL10/CXCR3 axis in hepatocellular carcinoma (HCC).
Volume: 506
Pages: 95-106
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Publication
31578309 | J:329648
 
First Author: Kaesler S
Year: 2019
Journal: JCI Insight
Title: Targeting tumor-resident mast cells for effective anti-melanoma immune responses.
Volume: 4
Issue: 19
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Publication
23431040 | J:315268
First Author: Chandrasekar B
Year: 2013
Journal: J Infect Dis
Title: Regulation of chemokines, CCL3 and CCL4, by interferon γ and nitric oxide synthase 2 in mouse macrophages and during Salmonella enterica serovar typhimurium infection.
Volume: 207
Issue: 10
Pages: 1556-68
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Publication
34272885 | J:309475
First Author: Akeus P
Year: 2021
Journal: Eur J Immunol
Title: Regulatory T cells reduce endothelial neutral sphingomyelinase 2 to prevent T-cell migration into tumors.
Volume: 51
Issue: 9
Pages: 2317-2329
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Publication
28447667 | J:323760
 
First Author: Fernández-Laso V
Year: 2017
Journal: Sci Rep
Title: TWEAK blockade decreases atherosclerotic lesion size and progression through suppression of STAT1 signaling in diabetic mice.
Volume: 7
Pages: 46679
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Publication
25300859 | J:320629
First Author: Ohkuri T
Year: 2014
Journal: Cancer Immunol Res
Title: STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment.
Volume: 2
Issue: 12
Pages: 1199-208
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Publication
35841281 | J:327323
First Author: Antonia RJ
Year: 2022
Journal: J Cell Mol Med
Title: STAT3 regulates inflammatory cytokine production downstream of TNFR1 by inducing expression of TNFAIP3/A20.
Volume: 26
Issue: 16
Pages: 4591-4601
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Publication
37455566 | J:342825
First Author: Schröder LJ
Year: 2023
Journal: Glia
Title: Dynamics of reactive astrocytes fosters tissue regeneration after cuprizone-induced demyelination.
Volume: 71
Issue: 11
Pages: 2573-2590
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Publication
37531413 | J:343618
First Author: Dery KJ
Year: 2023
Journal: Sci Transl Med
Title: Alternative splicing of CEACAM1 by hypoxia-inducible factor-1α enhances tolerance to hepatic ischemia in mice and humans.
Volume: 15
Issue: 707
Pages: eadf2059
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Publication
32485165 | J:305370
First Author: Guo Y
Year: 2020
Journal: Cell Host Microbe
Title: During Aspergillus Infection, Monocyte-Derived DCs, Neutrophils, and Plasmacytoid DCs Enhance Innate Immune Defense through CXCR3-Dependent Crosstalk.
Volume: 28
Issue: 1
Pages: 104-116.e4
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Protein Coding Gene
MGI:102709 | Cav1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
9625760 | -
First Author: Cole KE
Year: 1998
Journal: J Exp Med
Title: Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3.
Volume: 187
Issue: 12
Pages: 2009-21
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Publication
9660793 | -
First Author: Weng Y
Year: 1998
Journal: J Biol Chem
Title: Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.
Volume: 273
Issue: 29
Pages: 18288-91
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Publication
9064356 | -
First Author: Loetscher M
Year: 1996
Journal: J Exp Med
Title: Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes.
Volume: 184
Issue: 3
Pages: 963-9
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Publication
11310833 | -
First Author: García-López MA
Year: 2001
Journal: Lab Invest
Title: CXCR3 chemokine receptor distribution in normal and inflamed tissues: expression on activated lymphocytes, endothelial cells, and dendritic cells.
Volume: 81
Issue: 3
Pages: 409-18
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Publication
12173928 | -
First Author: Booth V
Year: 2002
Journal: Biochemistry
Title: The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions.
Volume: 41
Issue: 33
Pages: 10418-25
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Publication
10233762 | -
First Author: Tensen CP
Year: 1999
Journal: J Invest Dermatol
Title: Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3).
Volume: 112
Issue: 5
Pages: 716-22
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Publication
12750173 | -
First Author: Smit MJ
Year: 2003
Journal: Blood
Title: CXCR3-mediated chemotaxis of human T cells is regulated by a Gi- and phospholipase C-dependent pathway and not via activation of MEK/p44/p42 MAPK nor Akt/PI-3 kinase.
Volume: 102
Issue: 6
Pages: 1959-65
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Publication
11085753 | J:65916
First Author: Hancock WW
Year: 2000
Journal: J Exp Med
Title: Requirement of the chemokine receptor CXCR3 for acute allograft rejection.
Volume: 192
Issue: 10
Pages: 1515-20
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Publication
10525042 | -
First Author: Mach F
Year: 1999
Journal: J Clin Invest
Title: Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells.
Volume: 104
Issue: 8
Pages: 1041-50
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Publication
17538187 | J:153194
First Author: Panzer U
Year: 2007
Journal: J Am Soc Nephrol
Title: Chemokine receptor CXCR3 mediates T cell recruitment and tissue injury in nephrotoxic nephritis in mice.
Volume: 18
Issue: 7
Pages: 2071-84
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Publication
9466968 | -
First Author: Qin S
Year: 1998
Journal: J Clin Invest
Title: The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.
Volume: 101
Issue: 4
Pages: 746-54
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Publication
16127166 | -
First Author: Curbishley SM
Year: 2005
Journal: Am J Pathol
Title: CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow.
Volume: 167
Issue: 3
Pages: 887-99
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Publication
10605606 | -
 
First Author: Loetscher P
Year: 2000
Journal: Adv Immunol
Title: Chemokines and their receptors in lymphocyte traffic and HIV infection.
Volume: 74
Pages: 127-80
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Publication
9987599 | -
First Author: Zlotnik A
Year: 1999
Journal: Crit Rev Immunol
Title: Recent advances in chemokines and chemokine receptors.
Volume: 19
Issue: 1
Pages: 1-47
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Publication
17600132 | J:123926
First Author: Yates CC
Year: 2007
Journal: Am J Pathol
Title: Delayed and deficient dermal maturation in mice lacking the CXCR3 ELR-negative CXC chemokine receptor.
Volume: 171
Issue: 2
Pages: 484-95
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Protein Domain
IPR004070 | Chemokine_CXCR3
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).The CXC chemokine receptors are a subfamily of chemokine receptors that specifically bind and respond to cytokines of the CXC chemokine family. There are currently seven known CXC chemokine receptors in mammals, CXCR1 through to CXCR7.This entry represents CXCR3, which is expressed in natural killer cells and activated T lymphocytes but not in resting T lymphocytes, B lymphocytes, monocytes or granulocytes [, ]. CXCR3 also appears to be constitutively expressed on endothelial cells of medium and large blood vessels []. CXCR3 is able to regulate leukocyte trafficking and binding to various chemokines inducing various cellular responses, most notably integrin activation, cytoskeletal changes and chemotactic migration [, , , ]. The main role of CXCR3 is the selective recruitment of effector T cells in both normal tissues and inflammation []and it is involved in a number of T cell-mediated inflammatory diseases, such as autoimmune diseases, delayed-type hypersensitivity responses, certain viral diseases and acute transplant rejection []. It has been implicated in atherosclerosis [], pulmonary fibrosis [], type 1 diabetes []and nephrotoxic nephritis [], and has been implicated in wound healing [].CXCR3 is the receptor for CXCL9 (Mig), CXCL10 (IP10) and CXCL11 (I-TAC), [, , , ], which are upregulated in response to interferon-gamma and are potent chemoattractants for activated T cells [, ]. All three chemokines elicit an increase in intracellular Ca2+ levels and activate phosphoinositide 3-kinase and mitogen-activated protein kinase (MAPK) []. CXCR3 is also capable of binding a number of CC chemokines with moderate affinity, including CCL11 (eotaxin), CCL13, CCL20, CCL7, CCL5 []. However, it has been reported that CCL11, despite binding with high affinity, may be neither an agonist or an antagonist of the CXCR3 receptor, but sequesters available CCL11 resulting in a lowered response at other receptors [].
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Publication
24470469 | J:209436
First Author: Yamamoto H
Year: 2014
Journal: Infect Immun
Title: Defect of CARD9 leads to impaired accumulation of gamma interferon-producing memory phenotype T cells in lungs and increased susceptibility to pulmonary infection with Cryptococcus neoformans.
Volume: 82
Issue: 4
Pages: 1606-15
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Publication
31376731 | J:304151
 
First Author: Zhong Y
Year: 2019
Journal: Mol Immunol
Title: The novel methyltransferase SETD4 regulates TLR agonist-induced expression of cytokines through methylation of lysine 4 at histone 3 in macrophages.
Volume: 114
Pages: 179-188
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Publication
23250032 | J:194607
First Author: Tan BM
Year: 2013
Journal: Diabetologia
Title: Baculoviral inhibitors of apoptosis repeat containing (BIRC) proteins fine-tune TNF-induced nuclear factor κB and c-Jun N-terminal kinase signalling in mouse pancreatic beta cells.
Volume: 56
Issue: 3
Pages: 520-32
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Publication
35593740 | J:329395
First Author: Fabris L
Year: 2022
Journal: FASEB J
Title: Dysregulation of the Scribble/YAP/β-catenin axis sustains the fibroinflammatory response in a PKHD1-/- mouse model of congenital hepatic fibrosis.
Volume: 36
Issue: 6
Pages: e22364
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Publication
31712384 | J:282217
First Author: Zacharias ZR
Year: 2019
Journal: J Immunol
Title: Chronic Ethanol Consumption Reduces Existing CD8 T Cell Memory and Is Associated with Lesions in Protection against Secondary Influenza A Virus Infections.
Volume: 203
Issue: 12
Pages: 3313-3324
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Publication
21249144 | J:180832
First Author: Wu CL
Year: 2011
Journal: PLoS One
Title: Identification of genes that elicit disuse muscle atrophy via the transcription factors p50 and Bcl-3.
Volume: 6
Issue: 1
Pages: e16171
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Publication
27273587 | J:247260
First Author: Bleau C
Year: 2016
Journal: Immunology
Title: Toll-like receptor-2 exacerbates murine acute viral hepatitis.
Volume: 149
Issue: 2
Pages: 204-24
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Publication
27727269 | J:254475
First Author: Liu Z
Year: 2016
Journal: PLoS One
Title: Characteristics of Allergic Pulmonary Inflammation in CXCR3Knockout Mice Sensitized and Challenged with House Dust Mite Protein.
Volume: 11
Issue: 10
Pages: e0162905
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Publication
21270150 | J:343106
First Author: Stubblefield Park SR
Year: 2011
Journal: J Virol
Title: T cell-, interleukin-12-, and gamma interferon-driven viral clearance in measles virus-infected brain tissue.
Volume: 85
Issue: 7
Pages: 3664-76
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Publication
32238474 | J:328906
First Author: Viau A
Year: 2020
Journal: J Am Soc Nephrol
Title: Tubular STAT3 Limits Renal Inflammation in Autosomal Dominant Polycystic Kidney Disease.
Volume: 31
Issue: 5
Pages: 1035-1049
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Publication
30964207 | J:273129
     
First Author: He Y
Year: 2019
Journal: Hepatology
Title: MicroRNA-223 ameliorates nonalcoholic steatohepatitis and cancer by targeting multiple inflammatory and oncogenic genes in hepatocytes.
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Publication
30202097 | J:314677
First Author: Coburn LA
Year: 2019
Journal: Oncogene
Title: Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis.
Volume: 38
Issue: 7
Pages: 1067-1079
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Publication
29186131 | J:274051
First Author: Rudobeck E
Year: 2017
Journal: PLoS One
Title: Low-dose proton radiation effects in a transgenic mouse model of Alzheimer's disease - Implications for space travel.
Volume: 12
Issue: 11
Pages: e0186168
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Publication
35025971 | J:322524
First Author: Sohail A
Year: 2022
Journal: PLoS Pathog
Title: Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection.
Volume: 18
Issue: 1
Pages: e1010219
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Publication
27709605 | J:246260
First Author: Rodríguez M
Year: 2017
Journal: Immunology
Title: Fungal pattern receptors down-regulate the inflammatory response by a cross-inhibitory mechanism independent of interleukin-10 production.
Volume: 150
Issue: 2
Pages: 184-198
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Publication
32780864 | J:293804
First Author: Bucher F
Year: 2020
Journal: Invest Ophthalmol Vis Sci
Title: CNTF Prevents Development of Outer Retinal Neovascularization Through Upregulation of CxCl10.
Volume: 61
Issue: 10
Pages: 20
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Publication
34557202 | J:311198
 
First Author: Liao YC
Year: 2021
Journal: Front Immunol
Title: NOX2-Deficient Neutrophils Facilitate Joint Inflammation Through Higher Pro-Inflammatory and Weakened Immune Checkpoint Activities.
Volume: 12
Pages: 743030
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Publication
25633245 | J:345748
First Author: Mastronardi CA
Year: 2015
Journal: Neuroimmunomodulation
Title: Temporal gene expression in the hippocampus and peripheral organs to endotoxin-induced systemic inflammatory response in caspase-1-deficient mice.
Volume: 22
Issue: 4
Pages: 263-73
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Publication
20585034 | J:162468
First Author: Ellis SL
Year: 2010
Journal: J Immunol
Title: The cell-specific induction of CXC chemokine ligand 9 mediated by IFN-gamma in microglia of the central nervous system is determined by the myeloid transcription factor PU.1.
Volume: 185
Issue: 3
Pages: 1864-77
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Publication
17114181 | J:118553
First Author: Kaur S
Year: 2007
Journal: J Biol Chem
Title: Regulatory effects of mammalian target of rapamycin-activated pathways in type I and II interferon signaling.
Volume: 282
Issue: 3
Pages: 1757-68
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Publication
21324923 | J:170897
First Author: Fujita M
Year: 2011
Journal: Cancer Res
Title: COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells.
Volume: 71
Issue: 7
Pages: 2664-74
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Publication
22615863 | J:187233
First Author: Chen SH
Year: 2012
Journal: PLoS One
Title: Persistent hepatitis B viral replication in a FVB/N mouse model: impact of host and viral factors.
Volume: 7
Issue: 5
Pages: e36984
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Publication
23872390 | J:207042
 
First Author: Listwak SJ
Year: 2013
Journal: Neuroscience
Title: Minimal NF-κB activity in neurons.
Volume: 250
Pages: 282-299
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Publication
25935869 | J:258776
First Author: Teunissen PF
Year: 2015
Journal: Cardiovasc Res
Title: MAb therapy against the IFN-α/β receptor subunit 1 stimulates arteriogenesis in a murine hindlimb ischaemia model without enhancing atherosclerotic burden.
Volume: 107
Issue: 2
Pages: 255-66
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Publication
29858401 | J:280015
First Author: Tsiantoulas D
Year: 2018
Journal: Circulation
Title: B Cell-Activating Factor Neutralization Aggravates Atherosclerosis.
Volume: 138
Issue: 20
Pages: 2263-2273
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Publication
33717066 | J:308256
 
First Author: Hu L
Year: 2021
Journal: Front Immunol
Title: Interleukin-22 From Type 3 Innate Lymphoid Cells Aggravates Lupus Nephritis by Promoting Macrophage Infiltration in Lupus-Prone Mice.
Volume: 12
Pages: 584414
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Publication
33239787 | J:338001
First Author: Gola A
Year: 2021
Journal: Nature
Title: Commensal-driven immune zonation of the liver promotes host defence.
Volume: 589
Issue: 7840
Pages: 131-136
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Publication
25725353 | J:221046
 
First Author: Syeda S
Year: 2015
Journal: Exp Neurol
Title: Reduced photoreceptor death and improved retinal function during retinal degeneration in mice lacking innate immunity adaptor protein MyD88.
Volume: 267
Pages: 1-12
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Publication
30915078 | J:295867
 
First Author: Berretta F
Year: 2019
Journal: Front Immunol
Title: Plasmodium chabaudi AS Infection Induces CD4+ Th1 Cells and Foxp3+T-bet+ Regulatory T Cells That Express CXCR3 and Migrate to CXCR3 Ligands.
Volume: 10
Pages: 425
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Publication
24930935 | J:336548
 
First Author: Krauthausen M
Year: 2014
Journal: J Neuroinflammation
Title: CXCR3 modulates glial accumulation and activation in cuprizone-induced demyelination of the central nervous system.
Volume: 11
Pages: 109
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Publication
28100749 | J:238396
First Author: Jiang BC
Year: 2017
Journal: J Neurosci
Title: Promoted Interaction of C/EBPα with Demethylated Cxcr3 Gene Promoter Contributes to Neuropathic Pain in Mice.
Volume: 37
Issue: 3
Pages: 685-700
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Publication
34332594 | J:325221
First Author: Guo X
Year: 2021
Journal: J Neuroinflammation
Title: Aicardi-Goutières syndrome-associated mutation at ADAR1 gene locus activates innate immune response in mouse brain.
Volume: 18
Issue: 1
Pages: 169
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Publication
37033925 | J:345685
 
First Author: Church KA
Year: 2023
Journal: Front Immunol
Title: Pharmacological depletion of microglia alleviates neuronal and vascular damage in the diabetic CX3CR1-WT retina but not in CX3CR1-KO or hCX3CR1(I249/M280)-expressing retina.
Volume: 14
Pages: 1130735
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Publication
32050001 | J:285315
First Author: Jodeleit H
Year: 2020
Journal: PLoS One
Title: Autoantibodies as diagnostic markers and potential drivers of inflammation in ulcerative colitis.
Volume: 15
Issue: 2
Pages: e0228615
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Publication
33602265 | J:317317
First Author: Du X
Year: 2021
Journal: Mol Neurodegener
Title: Deletion of Socs3 in LysM+ cells and Cx3cr1 resulted in age-dependent development of retinal microgliopathy.
Volume: 16
Issue: 1
Pages: 9
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Publication
10699158 | -
First Author: Murphy PM
Year: 2000
Journal: Pharmacol Rev
Title: International union of pharmacology. XXII. Nomenclature for chemokine receptors.
Volume: 52
Issue: 1
Pages: 145-76
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Protein
O88410
Organism: Mus musculus/domesticus
Length: 367  
Fragment?: false
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Publication
9689100 | J:49070
First Author: Ma Q
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.
Volume: 95
Issue: 16
Pages: 9448-53
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Publication
11544102 | -
First Author: Horuk R
Year: 2001
Journal: Cytokine Growth Factor Rev
Title: Chemokine receptors.
Volume: 12
Issue: 4
Pages: 313-35
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Publication
10601351 | -
First Author: Charbonnier AS
Year: 1999
Journal: J Exp Med
Title: Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells.
Volume: 190
Issue: 12
Pages: 1755-68
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Publication
9500790 | -
First Author: Sallusto F
Year: 1998
Journal: J Exp Med
Title: Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes.
Volume: 187
Issue: 6
Pages: 875-83
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Publication
7592998 | -
First Author: Strieter RM
Year: 1995
Journal: J Biol Chem
Title: The functional role of the ELR motif in CXC chemokine-mediated angiogenesis.
Volume: 270
Issue: 45
Pages: 27348-57
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Publication
10714678 | -
First Author: Zlotnik A
Year: 2000
Journal: Immunity
Title: Chemokines: a new classification system and their role in immunity.
Volume: 12
Issue: 2
Pages: 121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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