Type |
Details |
Score |
Publication |
First Author: |
Yamaguchi S |
Year: |
2012 |
Journal: |
Nature |
Title: |
Tet1 controls meiosis by regulating meiotic gene expression. |
Volume: |
492 |
Issue: |
7429 |
Pages: |
443-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Linscott ML |
Year: |
2019 |
Journal: |
PLoS One |
Title: |
TET1 regulates fibroblast growth factor 8 transcription in gonadotropin releasing hormone neurons. |
Volume: |
14 |
Issue: |
7 |
Pages: |
e0220530 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang M |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain. |
Volume: |
12 |
Issue: |
1 |
Pages: |
5091 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen GD |
Year: |
2023 |
Journal: |
Sci Adv |
Title: |
DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation. |
Volume: |
9 |
Issue: |
2 |
Pages: |
eabo7605 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okashita N |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
TET2 catalyzes active DNA demethylation of the Sry promoter and enhances its expression. |
Volume: |
9 |
Issue: |
1 |
Pages: |
13462 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shin SW |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice. |
Volume: |
8 |
Issue: |
1 |
Pages: |
1643 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reyes-Aguirre LI |
Year: |
2016 |
Journal: |
Front Neurosci |
Title: |
Oct4 Methylation-Mediated Silencing As an Epigenetic Barrier Preventing Müller Glia Dedifferentiation in a Murine Model of Retinal Injury. |
Volume: |
10 |
|
Pages: |
523 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dai HQ |
Year: |
2016 |
Journal: |
Nature |
Title: |
TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling. |
Volume: |
538 |
Issue: |
7626 |
Pages: |
528-532 |
|
•
•
•
•
•
|
Publication |
First Author: |
Keil KP |
Year: |
2013 |
Journal: |
Gene Expr Patterns |
Title: |
Catalog of mRNA expression patterns for DNA methylating and demethylating genes in developing mouse lower urinary tract. |
Volume: |
13 |
Issue: |
8 |
Pages: |
413-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu C |
Year: |
2013 |
Journal: |
Science |
Title: |
CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. |
Volume: |
342 |
Issue: |
6165 |
Pages: |
1518-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Manti M |
Year: |
2020 |
Journal: |
FASEB J |
Title: |
Excess of ovarian nerve growth factor impairs embryonic development and causes reproductive and metabolic dysfunction in adult female mice. |
Volume: |
34 |
Issue: |
11 |
Pages: |
14440-14457 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thuret S |
Year: |
2004 |
Journal: |
Mol Cell Neurosci |
Title: |
Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta. |
Volume: |
25 |
Issue: |
3 |
Pages: |
394-405 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wertz K |
Year: |
2000 |
Journal: |
Mech Dev |
Title: |
Large-scale screen for genes involved in gonad development. |
Volume: |
98 |
Issue: |
1-2 |
Pages: |
51-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
MGC Data curation in Mouse Genome Informatics |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
Data Curation Using Mouse Genome Assembly |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Xu Y |
Year: |
2012 |
Journal: |
Cell |
Title: |
Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development. |
Volume: |
151 |
Issue: |
6 |
Pages: |
1200-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jin SG |
Year: |
2016 |
Journal: |
Cell Rep |
Title: |
Tet3 Reads 5-Carboxylcytosine through Its CXXC Domain and Is a Potential Guardian against Neurodegeneration. |
Volume: |
14 |
Issue: |
3 |
Pages: |
493-505 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1803
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1784
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
719
|
Fragment?: |
false |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE61329 |
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Allele |
Name: |
tet methylcytosine dioxygenase 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Allele |
Name: |
tet methylcytosine dioxygenase 3; targeted mutation 1.1, Shanghai Model Organisms Center |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Q |
Year: |
2013 |
Journal: |
Nature |
Title: |
TET2 promotes histone O-GlcNAcylation during gene transcription. |
Volume: |
493 |
Issue: |
7433 |
Pages: |
561-4 |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
141
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Rasmussen KD |
Year: |
2016 |
Journal: |
Genes Dev |
Title: |
Role of TET enzymes in DNA methylation, development, and cancer. |
Volume: |
30 |
Issue: |
7 |
Pages: |
733-50 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene expression []. TET proteins, including TET1/2/3, convert 5-methylcytosine to 5-hydroxymethylcytosine. They can also convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine []. They play roles in epigenetic regulation [, ]. Human TET2 mutations have been linked to various leukaemias. TET2 and TET3 interact with O-GlcNAc transferase (OGT) and promotes OGT-mediated GlcNAcylation []. The double epigenetic modifications on both DNA and histones by TET2 and OGT coordinate together for the regulation of gene transcription []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Tu J |
Year: |
2018 |
Journal: |
Exp Cell Res |
Title: |
MicroRNA-26b promotes transition from Kit- to Kit+ mouse spermatogonia. |
Volume: |
373 |
Issue: |
1-2 |
Pages: |
71-79 |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Dawlaty MM |
Year: |
2013 |
Journal: |
Dev Cell |
Title: |
Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development. |
Volume: |
24 |
Issue: |
3 |
Pages: |
310-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Canzio D |
Year: |
2019 |
Journal: |
Cell |
Title: |
Antisense lncRNA Transcription Mediates DNA Demethylation to Drive Stochastic Protocadherin α Promoter Choice. |
Volume: |
177 |
Issue: |
3 |
Pages: |
639-653.e15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hahn MA |
Year: |
2013 |
Journal: |
Cell Rep |
Title: |
Dynamics of 5-hydroxymethylcytosine and chromatin marks in Mammalian neurogenesis. |
Volume: |
3 |
Issue: |
2 |
Pages: |
291-300 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu X |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis. |
Volume: |
9 |
Issue: |
1 |
Pages: |
3509 |
|
•
•
•
•
•
|
Publication |
First Author: |
Weng YL |
Year: |
2017 |
Journal: |
Neuron |
Title: |
An Intrinsic Epigenetic Barrier for Functional Axon Regeneration. |
Volume: |
94 |
Issue: |
2 |
Pages: |
337-346.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mi Y |
Year: |
2015 |
Journal: |
Int J Mol Sci |
Title: |
A Novel Function of TET2 in CNS: Sustaining Neuronal Survival. |
Volume: |
16 |
Issue: |
9 |
Pages: |
21846-57 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1912
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1921
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
267
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1668
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1920
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
179
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
138
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
68
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
399
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
157
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Yan H |
Year: |
2020 |
Journal: |
Clin Epigenetics |
Title: |
Ten-eleven translocation methyl-cytosine dioxygenase 2 deficiency exacerbates renal ischemia-reperfusion injury. |
Volume: |
12 |
Issue: |
1 |
Pages: |
98 |
|
•
•
•
•
•
|
Publication |
First Author: |
Veloso Pereira BM |
Year: |
2023 |
Journal: |
Front Endocrinol (Lausanne) |
Title: |
DNA methylation enzymes in the kidneys of male and female BTBR ob/ob mice. |
Volume: |
14 |
|
Pages: |
1167546 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Z |
Year: |
2015 |
Journal: |
Int J Mol Sci |
Title: |
Gene Expression Profiles of Main Olfactory Epithelium in Adenylyl Cyclase 3 Knockout Mice. |
Volume: |
16 |
Issue: |
12 |
Pages: |
28320-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sakashita A |
Year: |
2014 |
Journal: |
Genes Cells |
Title: |
Dynamics of genomic 5-hydroxymethylcytosine during mouse oocyte growth. |
Volume: |
19 |
Issue: |
8 |
Pages: |
629-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Seshagiri S |
Year: |
2012 |
Journal: |
Nature |
Title: |
Recurrent R-spondin fusions in colon cancer. |
Volume: |
488 |
Issue: |
7413 |
Pages: |
660-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ko M |
Year: |
2013 |
Journal: |
Nature |
Title: |
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX. |
Volume: |
497 |
Issue: |
7447 |
Pages: |
122-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang P |
Year: |
2017 |
Journal: |
Nucleic Acids Res |
Title: |
Methyl-CpG binding domain protein 1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner. |
Volume: |
45 |
Issue: |
12 |
Pages: |
7118-7136 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shukla V |
Year: |
2022 |
Journal: |
Nat Immunol |
Title: |
TET deficiency perturbs mature B cell homeostasis and promotes oncogenesis associated with accumulation of G-quadruplex and R-loop structures. |
Volume: |
23 |
Issue: |
1 |
Pages: |
99-108 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu M |
Year: |
2023 |
Journal: |
Front Genet |
Title: |
Nrf2(-/-) regulated lung DNA demethylation and CYP2E1 DNA methylation under PM(2.5) exposure. |
Volume: |
14 |
|
Pages: |
1144903 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2007
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2039
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2039
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo A |
Year: |
2014 |
Journal: |
Mol Cell Proteomics |
Title: |
Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. |
Volume: |
13 |
Issue: |
1 |
Pages: |
372-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
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