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Search results 301 to 390 out of 390 for Dpp4

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Type Details Score
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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HT Experiment
GSE209525 | Senohemostatic role for DPP4 in atherosclerosis
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Dpp4<tm1Ddr> | MGI:6109965
Name: dipeptidylpeptidase 4; targeted mutation 1, DJ Drucker
Allele Type: Targeted
Attribute String: Conditional ready
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Allele
Dpp4<tm1c(EUCOMM)Wtsi> | MGI:7447016
Name: dipeptidylpeptidase 4; targeted mutation 1c, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready
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Publication
24639549 | J:207292
First Author: Pang Z
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Therapeutic vaccine against DPP4 improves glucose metabolism in mice.
Volume: 111
Issue: 13
Pages: E1256-63
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Publication
27535784 | J:257808
 
First Author: Glorie L
Year: 2016
Journal: Bone
Title: Boning up on DPP4, DPP4 substrates, and DPP4-adipokine interactions: Logical reasoning and known facts about bone related effects of DPP4 inhibitors.
Volume: 92
Pages: 37-49
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Publication
33431849 | J:301064
First Author: Lau SKP
Year: 2021
Journal: Nat Commun
Title: Isolation of MERS-related coronavirus from lesser bamboo bats that uses DPP4 and infects human-DPP4-transgenic mice.
Volume: 12
Issue: 1
Pages: 216
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Publication
37097759 | -
 
First Author: Herman AB
Year: 2023
Journal: J Clin Invest
Title: DPP4 inhibition impairs senohemostasis to improve plaque stability in atherosclerotic mice.
Volume: 133
Issue: 12
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Allele
Dpp4<em2(DPP4)Smoc> | MGI:6415291
Name: dipeptidylpeptidase 4; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Inserted expressed sequence
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Strain
MGI:6354744 | C57BL/6J-Dpp4<em2(DPP4)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
30634407 | J:295108
 
First Author: Jiang Y
Year: 2019
Journal: Viruses
Title: Complement Receptor C5aR1 Inhibition Reduces Pyroptosis in hDPP4-Transgenic Mice Infected with MERS-CoV.
Volume: 11
Issue: 1
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Allele
Tg(CAG-DPP4)52Ctkt | MGI:6402051
Name: transgene insertion 52, Chien-Te K Tseng
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
32384116 | J:288262
First Author: Choi JH
Year: 2020
Journal: PLoS One
Title: Characterization of a human monoclonal antibody generated from a B-cell specific for a prefusion-stabilized spike protein of Middle East respiratory syndrome coronavirus.
Volume: 15
Issue: 5
Pages: e0232757
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Publication
25589660 | J:258199
First Author: Agrawal AS
Year: 2015
Journal: J Virol
Title: Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease.
Volume: 89
Issue: 7
Pages: 3659-70
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Allele
Tg(SFTPC-DPP4)3Pbmj | MGI:6402180
Name: transgene insertion 3, Paul B McCray Jr
Allele Type: Transgenic
Attribute String: Epitope tag, Humanized sequence, Inserted expressed sequence
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Allele
Tg(CAG-DPP4)4Yuzh | MGI:6402443
Name: transgene insertion 4, Yusen Zhou
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(DPP4)2Nnag | MGI:6403115
Name: transgene insertion 2, Noriyo Nagata
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
29152574 | J:286231
First Author: Zhou J
Year: 2017
Journal: Sci Adv
Title: Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus.
Volume: 3
Issue: 11
Pages: eaao4966
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Publication
31838832 | J:290259
First Author: Kim J
Year: 2020
Journal: J Microbiol Biotechnol
Title: Middle East Respiratory Syndrome-Coronavirus Infection into Established hDPP4-Transgenic Mice Accelerates Lung Damage Via Activation of the Pro-Inflammatory Response and Pulmonary Fibrosis.
Volume: 30
Issue: 3
Pages: 427-438
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Publication
31296843 | J:279324
First Author: Zhou H
Year: 2019
Journal: Nat Commun
Title: Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein.
Volume: 10
Issue: 1
Pages: 3068
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Publication
2845400 | J:22340
First Author: Charbonneau H
Year: 1988
Journal: Proc Natl Acad Sci U S A
Title: The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase.
Volume: 85
Issue: 19
Pages: 7182-6
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Publication
11593028 | -
First Author: Ishii T
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: CD26-mediated signaling for T cell activation occurs in lipid rafts through its association with CD45RO.
Volume: 98
Issue: 21
Pages: 12138-43
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Protein Domain
IPR016335 | Ptprc
Type: Family
Description: Receptor-type tyrosine-protein phosphatase C, also known as CD45, is a tyrosine-protein phosphatase required for T-cell activation through the antigen receptor []. It acts as a positive regulator of T-cell co-activation upon binding to DPP4 (CD26) [].
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Publication
30626688 | J:283077
 
First Author: Iwata-Yoshikawa N
Year: 2019
Journal: J Virol
Title: TMPRSS2 Contributes to Virus Spread and Immunopathology in the Airways of Murine Models after Coronavirus Infection.
Volume: 93
Issue: 6
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Allele
Dpp4<em1(DPP4)Mbp> | MGI:6856706
Name: dipeptidylpeptidase 4; endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
Allele Type: Endonuclease-mediated
Attribute String: Inserted expressed sequence, Null/knockout
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Publication
26446606 | J:227925
First Author: Tao X
Year: 2015
Journal: J Virol
Title: Characterization and Demonstration of the Value of a Lethal Mouse Model of Middle East Respiratory Syndrome Coronavirus Infection and Disease.
Volume: 90
Issue: 1
Pages: 57-67
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Publication
27269431 | J:291895
First Author: Agrawal AS
Year: 2016
Journal: Hum Vaccin Immunother
Title: Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus.
Volume: 12
Issue: 9
Pages: 2351-6
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Publication
27538452 | J:266753
 
First Author: Agrawal AS
Year: 2016
Journal: Sci Rep
Title: Passive Transfer of A Germline-like Neutralizing Human Monoclonal Antibody Protects Transgenic Mice Against Lethal Middle East Respiratory Syndrome Coronavirus Infection.
Volume: 6
Pages: 31629
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Publication
30256968 | J:286197
First Author: Algaissi A
Year: 2019
Journal: J Infect Dis
Title: Elevated Human Dipeptidyl Peptidase 4 Expression Reduces the Susceptibility of hDPP4 Transgenic Mice to Middle East Respiratory Syndrome Coronavirus Infection and Disease.
Volume: 219
Issue: 5
Pages: 829-835
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Strain
MGI:6455169 | B6;SJL-Tg(SFTPC-DPP4)3Pbmj/J
Attribute String: mutant stock, transgenic
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Allele
Tg(KRT18-DPP4)3Pbmj | MGI:6402178
Name: transgene insertion 3, Paul B McCray Jr
Allele Type: Transgenic
Attribute String: Epitope tag, Humanized sequence, Inserted expressed sequence
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Allele
Tg(Tk1-DPP4)27Ysj | MGI:6443611
Name: transgene insertion 27, Yong-Suk Jang
Allele Type: Transgenic
Attribute String: Epitope tag, Humanized sequence, Inserted expressed sequence
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Strain
MGI:6402444 | C57BL/6-Tg(CAG-DPP4)4Yuzh
Attribute String: transgenic, mutant strain, coisogenic
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Publication
26701103 | J:286175
First Author: Zhao G
Year: 2015
Journal: PLoS One
Title: Multi-Organ Damage in Human Dipeptidyl Peptidase 4 Transgenic Mice Infected with Middle East Respiratory Syndrome-Coronavirus.
Volume: 10
Issue: 12
Pages: e0145561
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Strain
MGI:6403117 | B6.Cg-Tg(DPP4)2Nnag
Attribute String: congenic, mutant strain, transgenic
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Genotype
Genotype
Symbol: Tg(CAG-DPP4)4Yuzh/?
Background: C57BL/6-Tg(CAG-DPP4)4Yuzh
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(CAG-DPP4)52Ctkt/?
Background: involves: C3H/HeJ * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(DPP4)2Nnag/?
Background: B6.Cg-Tg(DPP4)2Nnag
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(SFTPC-DPP4)3Pbmj/?
Background: involves: C57BL/6J * SJL/J
Zygosity: ot
Has Mutant Allele: true
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Publication
26486634 | J:285467
First Author: Li K
Year: 2016
Journal: J Infect Dis
Title: Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4.
Volume: 213
Issue: 5
Pages: 712-22
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Strain
MGI:7607349 | C57BL/6N-Ace2<em1(ACE2)Mbp> Dpp4<em1(DPP4)Mbp>/Mmucd
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:6866095 | C57BL/6N-Dpp4<em1Mbp>/Mmucd
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
31942559 | J:286454
First Author: Hao XY
Year: 2019
Journal: Animal Model Exp Med
Title: The characteristics of hDPP4 transgenic mice subjected to aerosol MERS coronavirus infection via an animal nose-only exposure device.
Volume: 2
Issue: 4
Pages: 269-281
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Strain
MGI:6455170 | B6;SJL-Tg(KRT18-DPP4)3Pbmj/J
Attribute String: transgenic, mutant stock
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Publication
- | J:295365
     
First Author: Knaap RC
Year: 2019
Journal: bioRxiv
Title: The deubiquitinating activity of Middle East respiratory syndrome coronavirus papain-like protease delays the innate immune response and enhances virulence in a mouse model.
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Publication
30631056 | J:291634
First Author: Yuan S
Year: 2019
Journal: Nat Commun
Title: SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target.
Volume: 10
Issue: 1
Pages: 120
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Publication
32747425 | J:291887
     
First Author: Rathnayake AD
Year: 2020
Journal: Sci Transl Med
Title: 3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice.
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Allele
Gt(ROSA)26Sor<em1(DPP4)Yowa> | MGI:6403442
Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Youchun Wang
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Inserted expressed sequence, Reporter
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Genotype
Genotype
Symbol: Tg(Tk1-DPP4)27Ysj/?
Background: involves: C57BL/6 * FVB/N
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(DPP4)2Nnag/? Tmprss2/Tmprss2
Background: involves: C57BL/6NCr * C57BL/6NTac * DBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(KRT18-DPP4)3Pbmj/?
Background: involves: C57BL/6J * SJL/J
Zygosity: ot
Has Mutant Allele: true
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Strain
MGI:6403445 | C57BL/6-Gt(ROSA)26Sor<em1(DPP4)Yowa>
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
30142928 | J:279060
 
First Author: Fan C
Year: 2018
Journal: Viruses
Title: A Human DPP4-Knockin Mouse's Susceptibility to Infection by Authentic and Pseudotyped MERS-CoV.
Volume: 10
Issue: 9
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Background: C57BL/6-Gt(ROSA)26Sor
Zygosity: hm
Has Mutant Allele: true
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Strain
MGI:7514790 | C57BL/6N-Ace2<em1(ACE2)Mbp> Tmprss2<em1(TMPRSS2)Mbp> Dpp4<em1(DPP4)Mbp>/Mmucd
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
27045475 | J:237880
 
First Author: Henderson JM
Year: 2017
Journal: Cancer Lett
Title: Hepatocellular carcinoma: Mouse models and the potential roles of proteases.
Volume: 387
Pages: 106-113
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Publication
31281892 | J:287565
First Author: Lee YS
Year: 2019
Journal: Sci Adv
Title: Hepatocyte-specific HIF-1α ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation.
Volume: 5
Issue: 7
Pages: eaaw4176
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Publication
35300413 | J:321971
 
First Author: Yoshitake R
Year: 2022
Journal: Front Cell Dev Biol
Title: Single-Cell Transcriptomics Identifies Heterogeneity of Mouse Mammary Gland Fibroblasts With Distinct Functions, Estrogen Responses, Differentiation Processes, and Crosstalks With Epithelium.
Volume: 10
Pages: 850568
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Protein
Q05C79
Organism: Mus musculus/domesticus
Length: 164  
Fragment?: true
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Protein
A0A0A6YXM4
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: true
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Publication
25211075 | -
First Author: Wang Q
Year: 2014
Journal: Cell Host Microbe
Title: Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26.
Volume: 16
Issue: 3
Pages: 328-37
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Protein Domain
IPR044378 | Spike_S1_RBD_HKU4-like
Type: Domain
Description: The CoV Spike (S) protein is an envelope glycoprotein that plays the most important role in viral attachment, fusion, and entry into host cells, and serves as a major target for the development of neutralizing antibodies, inhibitors of viral entry, and vaccines. It is synthesised as a precursor protein that is cleaved into an N-terminal S1 subunit (~700 amino acids) and a C-terminal S2 subunit (~600 amino acids) that mediates attachment and membrane fusion, respectively. Three S1/S2 heterodimers assemble to form a trimer spike protruding from the viral envelope. The S1 subunit contains a receptor-binding domain (RBD), while the S2 subunit contains a hydrophobic fusion peptide and two heptad repeat regions. S1 contains two structurally independent domains, the N-terminal domain (NTD) and the C-terminal domain (C-domain). Depending on the virus, either the NTD or the C-domain can serve as the receptor-binding domain (RBD). Most CoVs, including SARS-CoV-2, SARS-CoV, and MERS-CoV use the C-domain to bind their receptors. However, CoV such as mouse hepatitis virus (MHV) uses the NTD to bind its receptor, mouse carcinoembryonic antigen related cell adhesion molecule 1a (mCEACAM1a). The S1 NTD contributes to the Spike trimer interface [, , , , ].This entry represents the receptor-binding domain (RBD) of the S1 subunit of the spike (S) protein from Tylonycteris bat coronavirus HKU4 and other Middle East Respiratory Syndrome (MERS)-related coronaviruses which are phylogenetically closely related, sharing high sequence similarity. HKU4 is able to bind the MERS-CoV receptor, human dipeptidyl peptidase 4 (DPP4), also called CD26 but with lower affinity than MERS-CoV which indicates that HKU4 is less adapted to human DPP4 [].
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Publication
32333487 | J:287925
     
First Author: Natoli S
Year: 2020
Journal: Eur J Neurol
Title: Does SARS-Cov-2 invade the brain? Translational lessons from animal models.
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Publication
37310920 | J:341033
First Author: Strine MS
Year: 2023
Journal: PLoS Biol
Title: DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner.
Volume: 21
Issue: 6
Pages: e3002097
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Publication
29203510 | J:258050
First Author: Briere DA
Year: 2018
Journal: Diabetes
Title: Mechanisms to Elevate Endogenous GLP-1 Beyond Injectable GLP-1 Analogs and Metabolic Surgery.
Volume: 67
Issue: 2
Pages: 309-320
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Publication
35603786 | J:326225
 
First Author: Kim JH
Year: 2022
Journal: JCI Insight
Title: Bap1/SMN axis in Dpp4+ skeletal muscle mesenchymal cells regulates the neuromuscular system.
Volume: 7
Issue: 10
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Publication
19819973 | J:158215
First Author: Danilova OV
Year: 2009
Journal: Endocrinology
Title: Neurogenin 3-specific dipeptidyl peptidase-2 deficiency causes impaired glucose tolerance, insulin resistance, and visceral obesity.
Volume: 150
Issue: 12
Pages: 5240-8
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Publication
35196509 | J:324029
First Author: Takagishi M
Year: 2022
Journal: Curr Biol
Title: Nutritional control of thyroid morphogenesis through gastrointestinal hormones.
Volume: 32
Issue: 7
Pages: 1485-1496.e4
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Publication
28158223 | J:247145
First Author: Tan SY
Year: 2017
Journal: PLoS One
Title: Fibroblast activation protein is dispensable in the anti-influenza immune response in mice.
Volume: 12
Issue: 2
Pages: e0171194
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Publication
26175140 | J:249299
First Author: Zhang H
Year: 2015
Journal: FEBS J
Title: Identification of novel dipeptidyl peptidase 9 substrates by two-dimensional differential in-gel electrophoresis.
Volume: 282
Issue: 19
Pages: 3737-57
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Publication
29040423 | J:261097
First Author: Ziff OJ
Year: 2018
Journal: Cardiovasc Res
Title: Therapeutic strategies utilizing SDF-1α in ischaemic cardiomyopathy.
Volume: 114
Issue: 3
Pages: 358-367
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Publication
24324708 | J:291630
First Author: Du L
Year: 2013
Journal: PLoS One
Title: A truncated receptor-binding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses: implication for developing therapeutics and vaccines.
Volume: 8
Issue: 12
Pages: e81587
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Publication
31988243 | J:286249
First Author: Diaz-Jimenez D
Year: 2020
Journal: J Biol Chem
Title: Glucocorticoids mobilize macrophages by transcriptionally up-regulating the exopeptidase DPP4.
Volume: 295
Issue: 10
Pages: 3213-3227
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Publication
26184451 | J:284000
 
First Author: Gretebeck LM
Year: 2015
Journal: Curr Opin Virol
Title: Animal models for SARS and MERS coronaviruses.
Volume: 13
Pages: 123-9
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Publication
17717280 | J:132326
First Author: Flock G
Year: 2007
Journal: Diabetes
Title: Incretin receptors for glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide are essential for the sustained metabolic actions of vildagliptin in mice.
Volume: 56
Issue: 12
Pages: 3006-13
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Protein
P06800
Organism: Mus musculus/domesticus
Length: 1293  
Fragment?: false
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Protein
S4R1M0
Organism: Mus musculus/domesticus
Length: 1130  
Fragment?: false
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Protein
Q8C6Q7
Organism: Mus musculus/domesticus
Length: 879  
Fragment?: true
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Protein
Q3U382
Organism: Mus musculus/domesticus
Length: 1130  
Fragment?: false
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Protein
Q64730
Organism: Mus musculus/domesticus
Length: 1343  
Fragment?: false
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Publication
20702646 | -
First Author: Lau SK
Year: 2010
Journal: J Virol
Title: Coexistence of different genotypes in the same bat and serological characterization of Rousettus bat coronavirus HKU9 belonging to a novel Betacoronavirus subgroup.
Volume: 84
Issue: 21
Pages: 11385-94
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Publication
29500692 | -
First Author: Luo Y
Year: 2018
Journal: Virol Sin
Title: Longitudinal Surveillance of Betacoronaviruses in Fruit Bats in Yunnan Province, China During 2009-2016.
Volume: 33
Issue: 1
Pages: 87-95
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Publication
32203189 | -
First Author: Tai W
Year: 2020
Journal: Cell Mol Immunol
Title: Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine.
Volume: 17
Issue: 6
Pages: 613-620
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Publication
27578435 | -
First Author: Li F
Year: 2016
Journal: Annu Rev Virol
Title: Structure, Function, and Evolution of Coronavirus Spike Proteins.
Volume: 3
Issue: 1
Pages: 237-261
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Publication
32150576 | J:296119
First Author: Shang J
Year: 2020
Journal: PLoS Pathog
Title: Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry.
Volume: 16
Issue: 3
Pages: e1008392
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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