MLX-interacting protein (MLXIP, also known as MondoA) is a basic helix-loop-helix-leucine zipper transcriptional activator []. It forms a complex with MLX, and this complex regulates glucose-induced gene expression []. The transcriptional activity of the MondoA-Mlx complex is limited by mTOR-MondoA interaction [].The bHLH (basic Helix-Loop-Helix) proteins contain the bHLH domain that is approximately 60 amino acids long and consists of a DNA-binding basic region followed by two a-helices separated by a variable loop region (HLH). The HLH domain promotes dimerisation, allowing the formation of homo- or heterodimeric complexes between different family members. Many bHLH proteins have been shown to act as transcriptional regulators [].
