Type |
Details |
Score |
Allele |
Name: |
ectodysplasin A2 receptor; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
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Publication |
First Author: |
Song L |
Year: |
2021 |
Journal: |
Commun Biol |
Title: |
Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice. |
Volume: |
4 |
Issue: |
1 |
Pages: |
213 |
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•
•
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•
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Publication |
First Author: |
Wisniewski SA |
Year: |
2012 |
Journal: |
J Med Genet |
Title: |
A new mutation resulting in the truncation of the TRAF6-interacting domain of XEDAR: a possible novel cause of hypohidrotic ectodermal dysplasia. |
Volume: |
49 |
Issue: |
8 |
Pages: |
499-501 |
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Publication |
First Author: |
Tanikawa C |
Year: |
2010 |
Journal: |
Mol Cancer Res |
Title: |
Crosstalk of EDA-A2/XEDAR in the p53 signaling pathway. |
Volume: |
8 |
Issue: |
6 |
Pages: |
855-63 |
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•
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Publication |
First Author: |
Tanikawa C |
Year: |
2009 |
Journal: |
Oncogene |
Title: |
XEDAR as a putative colorectal tumor suppressor that mediates p53-regulated anoikis pathway. |
Volume: |
28 |
Issue: |
34 |
Pages: |
3081-92 |
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Publication |
First Author: |
Yan M |
Year: |
2000 |
Journal: |
Science |
Title: |
Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. |
Volume: |
290 |
Issue: |
5491 |
Pages: |
523-7 |
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Protein Domain |
Type: |
Domain |
Description: |
TNFRSF27 (also known as ectodysplasin-A2 receptor (EDA2R), X-linked ectodermal dysplasia receptor (XEDAR), EDAA2R, EDA-A2R) is a member of the TNFR superfamily that is recognised by ectodysplasin-A2 (EDA-A2), which is generated by alternative splicing of the EDA receptor (EDAR) ligand EDA-A1 []. It is highly expressed during embryonic development and binds to ectodysplasin-A2 (EDA-A2), playing a crucial role in the p53-signaling pathway. EDA2R is a direct p53 target that is frequently down-regulated in colorectal cancer tissues due to its epigenetic alterations or through the p53 gene mutations [, ]. Mutations in the EDA-A2/XEDAR signaling give rise to ectodermal dysplasia, characterized by loss of hair, sweat glands, and teeth []. A non-synonymous SNP on EDA2R, along with genetic variants in human androgen receptor is associated with androgenetic alopecia (AGA) [].This entry represents the N-terminal domain of TNFRSF27/XEDAR. TNF-receptors are modular proteins. The N-terminal extracellular part contains a cysteine-rich region responsible for ligand-binding. This region is composed of small modules of about 40 residues containing 6 conserved cysteines; the number and type of modules can vary in different members of the family [, , ]. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
297
![FASTA](model/images/fasta.gif) |
Fragment?: |
false |
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Publication |
First Author: |
Naismith JH |
Year: |
1998 |
Journal: |
Trends Biochem Sci |
Title: |
Modularity in the TNF-receptor family. |
Volume: |
23 |
Issue: |
2 |
Pages: |
74-9 |
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Publication |
First Author: |
Bodmer JL |
Year: |
2002 |
Journal: |
Trends Biochem Sci |
Title: |
The molecular architecture of the TNF superfamily. |
Volume: |
27 |
Issue: |
1 |
Pages: |
19-26 |
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•
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Publication |
First Author: |
Banner DW |
Year: |
1993 |
Journal: |
Cell |
Title: |
Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation. |
Volume: |
73 |
Issue: |
3 |
Pages: |
431-45 |
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Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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