Search our database by keyword

Examples

Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 101 to 113 out of 113 for Eda2r

<< First < Previous | Next > Last >>

0.022s

Type

Details

Score

Allele

Eda2r<em1Smoc> | MGI:7289440

Name:	ectodysplasin A2 receptor; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type:	Endonuclease-mediated
Attribute String:	Null/knockout

•

Strain

MGI:6428558 | C57BL/6J-Eda2R<em1Smoc>/Smoc

Attribute String:

coisogenic, mutant strain, endonuclease-mediated mutation

•

Publication

33594251 | J:334111

First Author:	Song L
Year:	2021
Journal:	Commun Biol
Title:	Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice.
Volume:	4
Issue:	1
Pages:	213

•

Publication

22889853 | -

First Author:	Wisniewski SA
Year:	2012
Journal:	J Med Genet
Title:	A new mutation resulting in the truncation of the TRAF6-interacting domain of XEDAR: a possible novel cause of hypohidrotic ectodermal dysplasia.
Volume:	49
Issue:	8
Pages:	499-501

•

Publication

20501644 | -

First Author:	Tanikawa C
Year:	2010
Journal:	Mol Cancer Res
Title:	Crosstalk of EDA-A2/XEDAR in the p53 signaling pathway.
Volume:	8
Issue:	6
Pages:	855-63

•

Publication

19543321 | -

First Author:	Tanikawa C
Year:	2009
Journal:	Oncogene
Title:	XEDAR as a putative colorectal tumor suppressor that mediates p53-regulated anoikis pathway.
Volume:	28
Issue:	34
Pages:	3081-92

•

Publication

11039935 | -

First Author:	Yan M
Year:	2000
Journal:	Science
Title:	Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors.
Volume:	290
Issue:	5491
Pages:	523-7

•

Protein Domain

IPR034060 | TNFRSF27_N

Type:

Domain

Description:

TNFRSF27 (also known as ectodysplasin-A2 receptor (EDA2R), X-linked ectodermal dysplasia receptor (XEDAR), EDAA2R, EDA-A2R) is a member of the TNFR superfamily that is recognised by ectodysplasin-A2 (EDA-A2), which is generated by alternative splicing of the EDA receptor (EDAR) ligand EDA-A1 []. It is highly expressed during embryonic development and binds to ectodysplasin-A2 (EDA-A2), playing a crucial role in the p53-signaling pathway. EDA2R is a direct p53 target that is frequently down-regulated in colorectal cancer tissues due to its epigenetic alterations or through the p53 gene mutations [, ]. Mutations in the EDA-A2/XEDAR signaling give rise to ectodermal dysplasia, characterized by loss of hair, sweat glands, and teeth []. A non-synonymous SNP on EDA2R, along with genetic variants in human androgen receptor is associated with androgenetic alopecia (AGA) [].This entry represents the N-terminal domain of TNFRSF27/XEDAR. TNF-receptors are modular proteins. The N-terminal extracellular part contains a cysteine-rich region responsible for ligand-binding. This region is composed of small modules of about 40 residues containing 6 conserved cysteines; the number and type of modules can vary in different members of the family [, , ].

•

Protein

Q8BX35

Organism:	Mus musculus/domesticus
Length:	297
Fragment?:	false

•

Publication

9538693 | -

First Author:	Naismith JH
Year:	1998
Journal:	Trends Biochem Sci
Title:	Modularity in the TNF-receptor family.
Volume:	23
Issue:	2
Pages:	74-9

•

Publication

11796220 | -

First Author:	Bodmer JL
Year:	2002
Journal:	Trends Biochem Sci
Title:	The molecular architecture of the TNF superfamily.
Volume:	27
Issue:	1
Pages:	19-26

•

Publication

8387891 | -

First Author:	Banner DW
Year:	1993
Journal:	Cell
Title:	Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.
Volume:	73
Issue:	3
Pages:	431-45

•

Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

•

Questions? Comments? Click here!

MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Your name:
Your email address:
Subject:
Message:	---- Current page: ---- /mousemine/keywordSearchResults.do;jsessionid=B20699687DE43873EEAB7A000339C5F6?searchTerm=Eda2r&searchBag=&searchOffset=100

MouseMine

Search our database by keyword

Examples

Search results 101 to 113 out of 113 for Eda2r

Categories

Hits by Pathway

Hits by Strain

Hits by Category