Neuropilins are essential multifunctional vertebrate cell surface receptors []. They function as receptors for axon guidance factor semaphorin class 3 (Sema3), vascular endothelial growth factor (VEGF) and placenta growth factor-2 (PLGF-2).Neuropilin-1 is involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, the PLGF-2 isoform of PLGF (placental growth factor), the VEGF-165 isoform of VEGF (vascular endothelial growth factor) and VEGF-B [, , , ].
This domain is found at the N-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55) and contains a coiled-coil domain that plays a critical role in NRP1 alternative splicing activity and self-oligomerization. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation [, ].
This entry represents the RNA recognition motif (RRM) of Nrp1 [], which contains an RNA recognition motif (RRM), two Ran-binding protein zinc fingers (Znf-RanBP), and an asparagine-rich region. The function of Nrp1 is not clear. It may be involved in ribosome biogenesis [].
This domain found at the C-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55) from mammals and aves. This is the RS-like domain, that resembles the arginine/serine-rich (RS) domain in other SR proteins, interacts with two SR proteins and with target mRNA, being essential for NRP1 activity. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation [, ].
Nodulin-related protein 1 (NRP1) may play a role in the negative-feedback regulation of the abscisic acid (ABA) synthesis pathway. Overexpression of NRP1 enhanced susceptibility to heat stress and was accompanied of decreased accumulation of ABA after heat treatment []. The function of NRP2 is not clear.
