The nonspecific lethal (NSL) complex associates with the histone acetyltransferase MOF (KAT8) in both Drosophila and mammals []. KAT8 regulatory NSL complex subunit 1 (KANSL1 or NSL1) is part of the NSL complex that is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription [].
This entry includes Mis14 from S. pombe, Nsl1 from S. cerevisiae and Nsl1 homologues from animals. MIs14 is a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle []. Nsl1 is an essential component of the kinetochore MIND complex, which is required for the spindle checkpoint and kinetochore integrity [].
This entry represents a group of plant MACPF domain-containing proteins, including CAD1 (also known as Protein CONSTITUTIVELY ACTIVATED CELL DEATH 1) and NSL1 (also known as Protein NECROTIC SPOTTED LESIONS 1) from Arabidopsis thaliana. They play a role in plant immunity acting as negative regulators of the salicylic acid (SA)-mediated pathway of programmed cell death [, , ].
