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Search results 201 to 300 out of 307 for Sorcs2

0.041s
Type Details Score
GXD Expression    
Probe: MGI:6189572
Assay Type: RNA in situ
Annotation Date: 2018-07-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189602
Age: postnatal day 7
Specimen Label: Table 2 P7
Detected: true
Specimen Num: 16
GXD Expression    
Probe: MGI:6189572
Assay Type: RNA in situ
Annotation Date: 2018-07-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189602
Age: postnatal day 7
Specimen Label: Table 2 P7
Detected: true
Specimen Num: 16
GXD Expression    
Probe: MGI:6189572
Assay Type: RNA in situ
Annotation Date: 2018-07-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189602
Age: postnatal day 7
Specimen Label: Table 2 P7
Detected: true
Specimen Num: 16
GXD Expression  
Probe: MGI:6189572
Assay Type: RNA in situ
Annotation Date: 2018-07-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3585928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6189602
Age: postnatal day 7
Note: Expression is in the lateral posterior thalamic nucleus and the medial thalamus nuclei.
Specimen Label: Table 2 P7
Detected: true
Specimen Num: 16
GXD Expression    
Probe: MGI:6189572
Assay Type: RNA in situ
Annotation Date: 2018-07-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3566628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189602
Age: postnatal adult
Specimen Label: Table 2 adult
Detected: true
Specimen Num: 17
GXD Expression    
Probe: MGI:6189572
Assay Type: RNA in situ
Annotation Date: 2018-07-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189602
Age: postnatal adult
Specimen Label: Table 2 adult
Detected: true
Specimen Num: 17
GXD Expression    
Probe: MGI:6189572
Assay Type: RNA in situ
Annotation Date: 2018-07-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1903728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189602
Age: postnatal adult
Specimen Label: Table 2 adult
Detected: true
Specimen Num: 17
GXD Expression    
Probe: MGI:6189572
Assay Type: RNA in situ
Annotation Date: 2018-07-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189602
Age: postnatal adult
Specimen Label: Table 2 adult
Detected: true
Specimen Num: 17
GXD Expression    
Probe: MGI:6189572
Assay Type: RNA in situ
Annotation Date: 2018-07-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189602
Age: postnatal adult
Specimen Label: Table 2 adult
Detected: true
Specimen Num: 17
GXD Expression    
Probe: MGI:6189572
Assay Type: RNA in situ
Annotation Date: 2018-07-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189602
Age: postnatal adult
Specimen Label: Table 2 adult
Detected: true
Specimen Num: 17
GXD Expression    
Probe: MGI:6189572
Assay Type: RNA in situ
Annotation Date: 2018-07-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189602
Age: postnatal adult
Specimen Label: Table 2 adult
Detected: true
Specimen Num: 17
GXD Expression    
Probe: MGI:6189572
Assay Type: RNA in situ
Annotation Date: 2018-07-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3673128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189602
Age: postnatal adult
Specimen Label: Table 2 adult
Detected: true
Specimen Num: 17
GXD Expression  
Probe: MGI:6189572
Assay Type: RNA in situ
Annotation Date: 2018-07-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3585928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6189602
Age: postnatal adult
Note: Expression is in the anteroventral thalamic nucleus.
Specimen Label: Table 2 adult
Detected: true
Specimen Num: 17
GXD Expression
Probe: MGI:6414636
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1906127
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:6414808
Age: postnatal day 0
Image: 2G
Note: Expression is localised to hair cells and supporting cells.
Specimen Label: 2G
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:6414636
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-05
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1906127
Stage: TS27
Assay Id: MGI:6414808
Age: postnatal day 0
Image: 2H
Note: No expression is seen in hair cells and supporting cells.
Specimen Label: 2H
Detected: false
Specimen Num: 8
GXD Expression
Probe: MGI:6414636
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3553526
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6414808
Age: embryonic day 18.0
Image: 2D
Note: Expression is localized to presumptive immature hair cells lacking stereociliary bundles and in hair cells with bundles.
Specimen Label: 2D
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:6414636
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3553526
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6414808
Age: embryonic day 18.0
Image: 2E
Note: Expression is localized to presumptive immature hair cells lacking stereociliary bundles and in hair cells with bundles.
Specimen Label: 2E
Detected: true
Specimen Num: 5
GXD Expression
Probe: MGI:6414636
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3279126
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6414808
Age: embryonic day 18.0
Image: 2F
Note: Expression is localized to presumptive immature hair cells lacking stereociliary bundles and in hair cells with bundles.
Specimen Label: 2F
Detected: true
Specimen Num: 6
GXD Expression
Probe: MGI:6414641
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1906127
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:6414812
Age: postnatal day 1
Image: S2A
Note: Expression is localised to supporting cells surrounding the outer hair cells and to the inner hair cells and their supporting cells.
Specimen Label: S2A
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:6414641
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3553527
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:6414812
Age: postnatal day 1
Image: S2B
Note: Expression is localised to hair cells.
Specimen Label: S2B
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:6414636
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6414808
Age: postnatal day 30
Image: S2G
Note: Expression is primarily seen in supporting cells.
Specimen Label: S2G
Detected: true
Specimen Num: 13
GXD Expression  
Probe: MGI:6414636
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-05
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1759723
Stage: TS23
Assay Id: MGI:6414808
Age: embryonic day 15.0-15.5
Image: 2A
Note: No expression is seen in the cochlear basal turn.
Specimen Label: 2A
Detected: false
Specimen Num: 1
GXD Expression
Probe: MGI:6414636
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3524726
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6414808
Age: embryonic day 18.0
Image: 2B
Note: Expression is localized to inner and outer hair cells in the basal turn.
Specimen Label: 2B
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:6414636
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3524726
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6414808
Age: embryonic day 18.0
Image: 2C
Note: Expression is localized to inner hair cells in the apical turn.
Specimen Label: 2C
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:6414636
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3524727
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:6414808
Age: postnatal day 1
Image: S2C
Note: Expression is localized to hair cells and supporting cells in the basal turn.
Specimen Label: S2C
Detected: true
Specimen Num: 9
GXD Expression
Probe: MGI:6414636
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3524727
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:6414808
Age: postnatal day 1
Image: S2D
Note: Expression is localized to hair cells and supporting cells in the apical turn.
Specimen Label: S2D
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:6414636
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-05
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3524727
Stage: TS27
Assay Id: MGI:6414808
Age: postnatal day 1
Image: S2E
Note: No expression was detected in the basal turn.
Specimen Label: S2E
Detected: false
Specimen Num: 11
GXD Expression  
Probe: MGI:6414636
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-05
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3524727
Stage: TS27
Assay Id: MGI:6414808
Age: postnatal day 1
Image: S2F
Note: No expression was detected in the apical turn.
Specimen Label: S2F
Detected: false
Specimen Num: 12
Publication
First Author: Oetjen S
Year: 2014
Journal: J Comp Neurol
Title: Spatiotemporal expression analysis of the growth factor receptor SorCS3.
Volume: 522
Issue: 15
Pages: 3386-402
Publication
First Author: Vignoli B
Year: 2021
Journal: Commun Biol
Title: Astrocytic microdomains from mouse cortex gain molecular control over long-term information storage and memory retention.
Volume: 4
Issue: 1
Pages: 1152
Publication
First Author: Siao CJ
Year: 2012
Journal: J Exp Med
Title: ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation.
Volume: 209
Issue: 12
Pages: 2291-305
Publication
First Author: Simon R
Year: 2003
Journal: Mol Cell Biol
Title: Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation.
Volume: 23
Issue: 24
Pages: 9046-60
Publication
First Author: Okazaki N
Year: 2002
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 9
Issue: 5
Pages: 179-88
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration
Year: 2001
Title: LocusLink Collaboration
Publication
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Component
Name: SorCS2 122 kDa chain
Component
Name: SorCS2 104 kDa chain
Component
Name: SorCS2 18 kDa chain
UniProt Feature  
Description: SorCS2 122 kDa chain
Type: chain
End: 1159
UniProt Feature
Begin: 50
Description: VPS10 domain-containing receptor SorCS2
Type: chain
End: 1159
UniProt Feature
Begin: 118
Description: SorCS2 104 kDa chain
Type: chain
End: 1030
UniProt Feature
Begin: 1031
Description: SorCS2 18 kDa chain
Type: chain
End: 1159
Protein
Organism: Mus musculus/domesticus
Length: 1159  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: false
Interaction Experiment
Description: SorCS2 is required for BDNF-dependent plasticity in the hippocampus.
Publication
First Author: Leloup N
Year: 2018
Journal: Nat Commun
Title: Structural insights into SorCS2-Nerve Growth Factor complex formation.
Volume: 9
Issue: 1
Pages: 2979
Publication
First Author: Deinhardt K
Year: 2011
Journal: Sci Signal
Title: Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac.
Volume: 4
Issue: 202
Pages: ra82
Publication
First Author: Giza JI
Year: 2018
Journal: Neuron
Title: The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior.
Volume: 99
Issue: 1
Pages: 163-178.e6
Publication
First Author: Hampe W
Year: 2001
Journal: Hum Genet
Title: The genes for the human VPS10 domain-containing receptors are large and contain many small exons.
Volume: 108
Issue: 6
Pages: 529-36
Protein Domain
Type: Domain
Description: The PKD (Polycystic Kidney Disease) domain was first identified in the Polycystic Kidney Disease protein, polycystin-1 (PDK1 gene), and contains an Ig-like fold consisting of a β-sandwich of seven strands in two sheets with a Greek key topology, although some members have additional strands []. Polycystin-1 is a large cell-surface glycoprotein involved in adhesive protein-protein and protein-carbohydrate interactions; however it is not clear if the PKD domain mediates any of these interactions. PKD domains are also found in other proteins, usually in the extracellular parts of proteins involved in interactions with other proteins. For example, domains with a PKD-type fold are found in archaeal surface layer proteins that protect the cell from extreme environments [], and in the human VPS10 domain-containing receptor SorCS2 [].
Publication
First Author: Jing H
Year: 2002
Journal: Structure
Title: Archaeal surface layer proteins contain beta propeller, PKD, and beta helix domains and are related to metazoan cell surface proteins.
Volume: 10
Issue: 10
Pages: 1453-64
Publication
First Author: Gundry RL
Year: 2009
Journal: Mol Cell Proteomics
Title: The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation.
Volume: 8
Issue: 11
Pages: 2555-69
Protein
Organism: Mus musculus/domesticus
Length: 574  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1048  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1081  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 626  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 838  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 574  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 626  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 526  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 574  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 574  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 782  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 985  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1085  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 574  
Fragment?: false
Publication
First Author: Bycroft M
Year: 1999
Journal: EMBO J
Title: The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease.
Volume: 18
Issue: 2
Pages: 297-305
Protein
Organism: Mus musculus/domesticus
Length: 2615  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2521  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 4293  
Fragment?: false
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90