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Search results 1 to 100 out of 404 for Atxn1

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Hits by Strain

Hits by Category

Type Details Score
Gene
6310 | ATXN1
Type: gene
Organism: human
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Gene
616399 | ATXN1
Type: gene
Organism: cattle
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Gene
702975 | ATXN1
Type: gene
Organism: macaque, rhesus
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Gene
100492711 | atxn1
Type: gene
Organism: frog, western clawed
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Gene
121106455 | ATXN1
Type: gene
Organism: chicken
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Gene
25049 | Atxn1
Type: gene
Organism: rat
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Gene
488232 | ATXN1
Type: gene
Organism: dog, domestic
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Gene
747421 | ATXN1
Type: gene
Organism: chimpanzee
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Protein Domain
IPR040172 | ATXN1
Type: Family
Description: Ataxin-1 (ATXN1) is involved in the formation and regulation of multimeric protein complexes within the nucleus []. It is the causative factor for spinocerebellar ataxia type 1 (SCA1), which manifests in poor co-ordination of hand and feet movement []. ATXN1 is a transcription repressor in the Notch signalling pathway []and colocalizes with the deubiquitinating enzyme USP7 in the nucleus [].
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Protein Coding Gene
MGI:104783 | Atxn1
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
101928433 | ATXN1-AS1
Type: gene
Organism: human
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Publication
19500214 | J:150968
First Author: Jorgensen ND
Year: 2009
Journal: J Neurochem
Title: Phosphorylation of ATXN1 at Ser776 in the cerebellum.
Volume: 110
Issue: 2
Pages: 675-86
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Publication
33554954 | J:305291
 
First Author: Nitschke L
Year: 2021
Journal: JCI Insight
Title: Modulation of ATXN1 S776 phosphorylation reveals the importance of allele-specific targeting in SCA1.
Volume: 6
Issue: 3
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Publication
36577402 | J:332730
     
First Author: Coffin SL
Year: 2022
Journal: Neuron
Title: Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1.
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Publication
7647801 | -
First Author: Servadio A
Year: 1995
Journal: Nat Genet
Title: Expression analysis of the ataxin-1 protein in tissues from normal and spinocerebellar ataxia type 1 individuals.
Volume: 10
Issue: 1
Pages: 94-8
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Publication
11001934 | -
First Author: Davidson JD
Year: 2000
Journal: Hum Mol Genet
Title: Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein.
Volume: 9
Issue: 15
Pages: 2305-12
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Publication
21475249 | -
First Author: Tong X
Year: 2011
Journal: EMBO Rep
Title: Ataxin-1 and Brother of ataxin-1 are components of the Notch signalling pathway.
Volume: 12
Issue: 5
Pages: 428-35
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Publication
12093161 | J:77464
First Author: Hong S
Year: 2002
Journal: Mol Cell Neurosci
Title: USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene product.
Volume: 20
Issue: 2
Pages: 298-306
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Publication
36577403 | J:343335
First Author: Handler HP
Year: 2023
Journal: Neuron
Title: Decreasing mutant ATXN1 nuclear localization improves a spectrum of SCA1-like phenotypes and brain region transcriptomic profiles.
Volume: 111
Issue: 4
Pages: 493-507.e6
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Publication
22014525 | J:178303
First Author: Lee Y
Year: 2011
Journal: Dev Cell
Title: ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization.
Volume: 21
Issue: 4
Pages: 746-57
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Publication
33478569 | J:309978
First Author: Ma Q
Year: 2021
Journal: Mol Brain
Title: The novel multiple sclerosis susceptibility gene ATXN1 regulates B cell receptor signaling in B-1a cells.
Volume: 14
Issue: 1
Pages: 19
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Protein
P54254
Organism: Mus musculus/domesticus
Length: 791  
Fragment?: false
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Protein
J3QPR1
Organism: Mus musculus/domesticus
Length: 799  
Fragment?: false
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Publication
26948890 | J:240150
First Author: Ingram M
Year: 2016
Journal: Neuron
Title: Cerebellar Transcriptome Profiles of ATXN1 Transgenic Mice Reveal SCA1 Disease Progression and Protection Pathways.
Volume: 89
Issue: 6
Pages: 1194-1207
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GXD Expression
GXD Expression
     
Probe: MGI:6168034
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6189828
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Atxn1
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6168034
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6189828
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Atxn1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6168034
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6189828
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Atxn1
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6168034
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6189828
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Atxn1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6168034
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189828
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Atxn1
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6168034
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189828
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Atxn1
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6168034
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189828
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Atxn1
Detected: true
Specimen Num: 7
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Publication
33436887 | J:300272
First Author: Asher M
Year: 2021
Journal: Sci Rep
Title: Mood alterations in mouse models of Spinocerebellar Ataxia type 1.
Volume: 11
Issue: 1
Pages: 713
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Publication
20869591 | J:166951
First Author: Duvick L
Year: 2010
Journal: Neuron
Title: SCA1-like disease in mice expressing wild-type ataxin-1 with a serine to aspartic acid replacement at residue 776.
Volume: 67
Issue: 6
Pages: 929-35
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Publication
25595967 | J:221437
 
First Author: Cvetanovic M
Year: 2015
Journal: Neuroscience
Title: Early activation of microglia and astrocytes in mouse models of spinocerebellar ataxia type 1.
Volume: 289
Pages: 289-99
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Publication
25446943 | J:218783
 
First Author: Öz G
Year: 2015
Journal: Neurobiol Dis
Title: Assessing recovery from neurodegeneration in spinocerebellar ataxia 1: Comparison of in vivo magnetic resonance spectroscopy with motor testing, gene expression and histology.
Volume: 74
Pages: 158-66
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Publication
23536093 | J:196583
First Author: Ebner BA
Year: 2013
Journal: J Neurosci
Title: Purkinje cell ataxin-1 modulates climbing fiber synaptic input in developing and adult mouse cerebellum.
Volume: 33
Issue: 13
Pages: 5806-20
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Publication
22001907 | J:178113
First Author: Cvetanovic M
Year: 2011
Journal: Nat Med
Title: Vascular endothelial growth factor ameliorates the ataxic phenotype in a mouse model of spinocerebellar ataxia type 1.
Volume: 17
Issue: 11
Pages: 1445-7
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Publication
26673892 | J:269462
   
First Author: Lasagna-Reeves CA
Year: 2015
Journal: Elife
Title: Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows Spinocerebellar ataxia type 1 phenotypes.
Volume: 4
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Publication
22884877 | J:197504
First Author: Cvetanovic M
Year: 2012
Journal: Neurobiol Dis
Title: LANP mediates neuritic pathology in Spinocerebellar ataxia type 1.
Volume: 48
Issue: 3
Pages: 526-32
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Publication
17322884 | J:119643
First Author: Bowman AB
Year: 2007
Journal: Nat Genet
Title: Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes.
Volume: 39
Issue: 3
Pages: 373-9
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Publication
23719801 | J:198661
First Author: Ju H
Year: 2013
Journal: J Neurosci
Title: Polyglutamine disease toxicity is regulated by Nemo-like kinase in spinocerebellar ataxia type 1.
Volume: 33
Issue: 22
Pages: 9328-36
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Publication
32620905 | J:293838
First Author: Zhang S
Year: 2020
Journal: Nat Commun
Title: The ataxin-1 interactome reveals direct connection with multiple disrupted nuclear transport pathways.
Volume: 11
Issue: 1
Pages: 3343
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Publication
21900557 | J:176576
First Author: Barnes JA
Year: 2011
Journal: J Neurosci
Title: Abnormalities in the climbing fiber-Purkinje cell circuitry contribute to neuronal dysfunction in ATXN1[82Q] mice.
Volume: 31
Issue: 36
Pages: 12778-89
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Publication
23630944 | J:199131
First Author: Sánchez I
Year: 2013
Journal: Hum Mol Genet
Title: A novel function of Ataxin-1 in the modulation of PP2A activity is dysregulated in the spinocerebellar ataxia type 1.
Volume: 22
Issue: 17
Pages: 3425-37
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Publication
29533923 | J:262714
First Author: Edamakanti CR
Year: 2018
Journal: J Clin Invest
Title: Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1.
Volume: 128
Issue: 6
Pages: 2252-2265
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Publication
31696233 | J:285794
First Author: Asher M
Year: 2020
Journal: Hum Mol Genet
Title: Cerebellar contribution to the cognitive alterations in SCA1: evidence from mouse models.
Volume: 29
Issue: 1
Pages: 117-131
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Publication
23328439 | J:197752
 
First Author: Takechi Y
Year: 2013
Journal: Neurosci Lett
Title: Impairment of spinal motor neurons in spinocerebellar ataxia type 1-knock-in mice.
Volume: 535
Pages: 67-72
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Publication
29419414 | J:257505
 
First Author: Orengo JP
Year: 2018
Journal: Dis Model Mech
Title: Motor neuron degeneration correlates with respiratory dysfunction in SCA1.
Volume: 11
Issue: 2
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Publication
23719381 | J:198731
First Author: Park J
Year: 2013
Journal: Nature
Title: RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1.
Volume: 498
Issue: 7454
Pages: 325-331
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Publication
22053053 | J:177841
First Author: Fryer JD
Year: 2011
Journal: Science
Title: Exercise and genetic rescue of SCA1 via the transcriptional repressor Capicua.
Volume: 334
Issue: 6056
Pages: 690-3
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Publication
25988806 | J:223296
   
First Author: Lasagna-Reeves CA
Year: 2015
Journal: Elife
Title: A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1.
Volume: 4
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Publication
29192206 | J:255878
First Author: Fujita K
Year: 2017
Journal: Nat Commun
Title: Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1.
Volume: 8
Issue: 1
Pages: 1864
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Publication
37827155 | J:342178
First Author: Gall-Duncan T
Year: 2023
Journal: Cell
Title: Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability.
Volume: 186
Issue: 22
Pages: 4898-4919.e25
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Publication
17110330 | J:116123
First Author: Serra HG
Year: 2006
Journal: Cell
Title: RORalpha-mediated Purkinje cell development determines disease severity in adult SCA1 mice.
Volume: 127
Issue: 4
Pages: 697-708
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Publication
17540008 | J:125062
First Author: Jorgensen ND
Year: 2007
Journal: J Neurochem
Title: Hsp70/Hsc70 regulates the effect phosphorylation has on stabilizing ataxin-1.
Volume: 102
Issue: 6
Pages: 2040-8
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Publication
18337722 | J:133952
First Author: Lim J
Year: 2008
Journal: Nature
Title: Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1.
Volume: 452
Issue: 7188
Pages: 713-8
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Publication
26876606 | J:235812
 
First Author: Asher M
Year: 2016
Journal: Neuroscience
Title: Ataxin-1 regulates proliferation of hippocampal neural precursors.
Volume: 322
Pages: 54-65
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Publication
21427130 | J:171629
First Author: Gehrking KM
Year: 2011
Journal: Hum Mol Genet
Title: Partial loss of Tip60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model.
Volume: 20
Issue: 11
Pages: 2204-12
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Publication
21245341 | J:169114
First Author: Jafar-Nejad P
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Regional rescue of spinocerebellar ataxia type 1 phenotypes by 14-3-3epsilon haploinsufficiency in mice underscores complex pathogenicity in neurodegeneration.
Volume: 108
Issue: 5
Pages: 2142-7
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Publication
17599952 | J:142935
First Author: Goold R
Year: 2007
Journal: Hum Mol Genet
Title: Down-regulation of the dopamine receptor D2 in mice lacking ataxin 1.
Volume: 16
Issue: 17
Pages: 2122-34
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Publication
24594842 | J:210660
First Author: Venkatraman A
Year: 2014
Journal: Hum Mol Genet
Title: The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1.
Volume: 23
Issue: 14
Pages: 3733-45
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Publication
25510912 | J:232602
First Author: Ito H
Year: 2015
Journal: EMBO Mol Med
Title: HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice.
Volume: 7
Issue: 1
Pages: 78-101
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Publication
20628574 | J:162235
First Author: Crespo-Barreto J
Year: 2010
Journal: PLoS Genet
Title: Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis.
Volume: 6
Issue: 7
Pages: e1001021
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Publication
31442405 | J:290398
First Author: Suh J
Year: 2019
Journal: Cell
Title: Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription.
Volume: 178
Issue: 5
Pages: 1159-1175.e17
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Publication
32878998 | J:296220
First Author: Didonna A
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Ataxin-1 regulates B cell function and the severity of autoimmune experimental encephalomyelitis.
Volume: 117
Issue: 38
Pages: 23742-23750
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Publication
27466200 | J:238569
First Author: Sánchez I
Year: 2016
Journal: Hum Mol Genet
Title: Ataxin-1 regulates the cerebellar bioenergetics proteome through the GSK3β-mTOR pathway which is altered in Spinocerebellar ataxia type 1 (SCA1).
Volume: 25
Issue: 18
Pages: 4021-4040
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Publication
29526553 | J:261279
First Author: Rousseaux MWC
Year: 2018
Journal: Neuron
Title: ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism.
Volume: 97
Issue: 6
Pages: 1235-1243.e5
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Protein Coding Gene
MGP_CAROLIEiJ_G0018479 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0020509 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0020463 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0020440 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0020459 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0020258 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_104783 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0020892 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0019773 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0020219 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0020341 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0020320 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0020416 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0020349 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0020935 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0019529 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0019835 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0019546 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0019357 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
9778246 | J:81242
First Author: Klement IA
Year: 1998
Journal: Cell
Title: Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.
Volume: 95
Issue: 1
Pages: 41-53
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Publication
12086639 | J:77225
First Author: Watase K
Year: 2002
Journal: Neuron
Title: A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration.
Volume: 34
Issue: 6
Pages: 905-19
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Publication
7553854 | J:28932
First Author: Burright EN
Year: 1995
Journal: Cell
Title: SCA1 transgenic mice: a model for neurodegeneration caused by an expanded CAG trinucleotide repeat.
Volume: 82
Issue: 6
Pages: 937-48
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Publication
9353120 | J:44095
First Author: Skinner PJ
Year: 1997
Journal: Nature
Title: Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures.
Volume: 389
Issue: 6654
Pages: 971-4
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Publication
30507379 | J:277255
   
First Author: Driessen TM
Year: 2018
Journal: Elife
Title: Molecular pathway analysis towards understanding tissue vulnerability in spinocerebellar ataxia type 1.
Volume: 7
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Publication
9295384 | J:43363
First Author: Clark HB
Year: 1997
Journal: J Neurosci
Title: Purkinje cell expression of a mutant allele of SCA1 in transgenic mice leads to disparate effects on motor behaviors, followed by a progressive cerebellar dysfunction and histological alterations.
Volume: 17
Issue: 19
Pages: 7385-95
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Publication
10749985 | J:61398
First Author: Lorenzetti D
Year: 2000
Journal: Hum Mol Genet
Title: Repeat instability and motor incoordination in mice with a targeted expanded CAG repeat in the Sca1 locus.
Volume: 9
Issue: 5
Pages: 779-85
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Publication
9651231 | J:48508
First Author: Matilla A
Year: 1998
Journal: J Neurosci
Title: Mice lacking ataxin-1 display learning deficits and decreased hippocampal paired-pulse facilitation.
Volume: 18
Issue: 14
Pages: 5508-16
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Publication
36078042 | J:328919
 
First Author: Luttik K
Year: 2022
Journal: Cells
Title: Identifying Disease Signatures in the Spinocerebellar Ataxia Type 1 Mouse Cortex.
Volume: 11
Issue: 17
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Publication
21420496 | J:177962
First Author: Chen KA
Year: 2011
Journal: Mol Cell Neurosci
Title: Cellular fusion for gene delivery to SCA1 affected Purkinje neurons.
Volume: 47
Issue: 1
Pages: 61-70
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Publication
23936457 | J:205774
First Author: Perroud B
Year: 2013
Journal: PLoS One
Title: Pharmacometabolomic signature of ataxia SCA1 mouse model and lithium effects.
Volume: 8
Issue: 8
Pages: e70610
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Publication
26531852 | J:274084
 
First Author: Hatanaka Y
Year: 2015
Journal: Sci Rep
Title: Abnormalities in synaptic dynamics during development in a mouse model of spinocerebellar ataxia type 1.
Volume: 5
Pages: 16102
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Publication
32214165 | J:286855
First Author: Tichanek F
Year: 2020
Journal: Sci Rep
Title: Hippocampal mitochondrial dysfunction and psychiatric-relevant behavioral deficits in spinocerebellar ataxia 1 mouse model.
Volume: 10
Issue: 1
Pages: 5418
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Publication
37445867 | J:337896
 
First Author: Sucha M
Year: 2023
Journal: Int J Mol Sci
Title: Experimental Treatment with Edaravone in a Mouse Model of Spinocerebellar Ataxia 1.
Volume: 24
Issue: 13
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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