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Search results 1 to 100 out of 209 for Polg

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Hits by Strain

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Type Details Score
Gene
5428 | POLG
Type: gene
Organism: human
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Gene
533090 | POLG
Type: gene
Organism: cattle
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Gene
100856383 | POLG
Type: gene
Organism: dog, domestic
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Gene
404292 | POLG
Type: gene
Organism: chicken
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Gene
100150924 | polg
Type: gene
Organism: zebrafish
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Gene
699750 | POLG
Type: gene
Organism: macaque, rhesus
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Gene
100488393 | polg
Type: gene
Organism: frog, western clawed
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Gene
85472 | Polg
Type: gene
Organism: rat
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Gene
467754 | POLG
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:1196389 | Polg
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
119545629 | POLG-DT
Type: gene
Organism: human
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Gene
125316803 | POLGARF
Type: gene
Organism: human
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Publication
29109127 | J:316083
First Author: Nikkanen J
Year: 2018
Journal: EMBO Mol Med
Title: A complex genomic locus drives mtDNA replicase POLG expression to its disease-related nervous system regions.
Volume: 10
Issue: 1
Pages: 13-21
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Publication
24722488 | J:215087
First Author: Hauser DN
Year: 2014
Journal: PLoS One
Title: Post-translational decrease in respiratory chain proteins in the Polg mutator mouse brain.
Volume: 9
Issue: 4
Pages: e94646
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Publication
26212336 | J:270683
 
First Author: Ni T
Year: 2015
Journal: Sci Rep
Title: MitoRCA-seq reveals unbalanced cytocine to thymine transition in Polg mutant mice.
Volume: 5
Pages: 12049
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Publication
29875308 | J:264412
First Author: Faraci C
Year: 2018
Journal: Reproduction
Title: Impact of exercise on oocyte quality in the POLG mitochondrial DNA mutator mouse.
Volume: 156
Issue: 2
Pages: 185-194
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Publication
26464968 | J:229612
 
First Author: Hauser DN
Year: 2015
Journal: eNeuro
Title: The Polg Mutator Phenotype Does Not Cause Dopaminergic Neurodegeneration in DJ-1-Deficient Mice.
Volume: 2
Issue: 1
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Publication
22225879 | J:303120
First Author: Ahlqvist KJ
Year: 2012
Journal: Cell Metab
Title: Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice.
Volume: 15
Issue: 1
Pages: 100-9
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Publication
21109200 | J:168109
First Author: Williams SL
Year: 2010
Journal: Cell Metab
Title: The mtDNA mutation spectrum of the progeroid Polg mutator mouse includes abundant control region multimers.
Volume: 12
Issue: 6
Pages: 675-82
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Publication
30240410 | J:266732
First Author: Faraci C
Year: 2018
Journal: PLoS One
Title: Calorie restriction does not influence oocyte quality in oocytes from POLG mitochondrial mutator mice.
Volume: 13
Issue: 9
Pages: e0204373
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Publication
28158260 | J:252031
First Author: Someya S
Year: 2017
Journal: PLoS One
Title: Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice.
Volume: 12
Issue: 2
Pages: e0171159
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Publication
26294258 | J:232253
First Author: Clark-Matott J
Year: 2015
Journal: Neurobiol Aging
Title: Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain.
Volume: 36
Issue: 11
Pages: 2972-2983
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Publication
32119683 | J:286178
First Author: Maclaine KD
Year: 2020
Journal: PLoS One
Title: Voluntary wheel running has no impact on brain and liver mitochondrial DNA copy number or mutation measures in the PolG mouse model of aging.
Volume: 15
Issue: 3
Pages: e0226860
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Publication
17122057 | J:116179
First Author: Kubota M
Year: 2006
Journal: J Neurosci
Title: Abnormal Ca2+ dynamics in transgenic mice with neuron-specific mitochondrial DNA defects.
Volume: 26
Issue: 47
Pages: 12314-24
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Publication
16619054 | J:127895
First Author: Kasahara T
Year: 2006
Journal: Mol Psychiatry
Title: Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes.
Volume: 11
Issue: 6
Pages: 577-93, 523
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Publication
9465903 | J:45383
First Author: Zullo SJ
Year: 1997
Journal: Cytogenet Cell Genet
Title: Localization by fluorescence in situ hybridization (FISH) of human mitochondrial polymerase gamma (POLG) to human chromosome band 15q24-->q26, and of mouse mitochondrial polymerase gamma (Polg) to mouse chromosome band 7E, with confirmation by direct sequence analysis of bacterial artificial chromosomes (BACs).
Volume: 78
Issue: 3-4
Pages: 281-4
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Publication
29950568 | J:266489
First Author: Nissanka N
Year: 2018
Journal: Nat Commun
Title: The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions.
Volume: 9
Issue: 1
Pages: 2491
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Publication
31621839 | J:286789
First Author: Ma H
Year: 2020
Journal: Biol Reprod
Title: Deleterious mtDNA mutations are common in mature oocytes.
Volume: 102
Issue: 3
Pages: 607-619
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Publication
30040856 | J:267870
First Author: Ma H
Year: 2018
Journal: PLoS One
Title: Germline and somatic mtDNA mutations in mouse aging.
Volume: 13
Issue: 7
Pages: e0201304
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Publication
26124126 | J:223723
First Author: Wall CE
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice.
Volume: 112
Issue: 28
Pages: 8714-9
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Publication
23935986 | J:204458
First Author: Joseph AM
Year: 2013
Journal: PLoS One
Title: Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging.
Volume: 8
Issue: 7
Pages: e69327
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Publication
17363114 | J:140916
First Author: Someya S
Year: 2008
Journal: Neurobiol Aging
Title: The role of mtDNA mutations in the pathogenesis of age-related hearing loss in mice carrying a mutator DNA polymerase gamma.
Volume: 29
Issue: 7
Pages: 1080-92
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Publication
25106705 | J:220113
 
First Author: Kolesar JE
Year: 2014
Journal: Free Radic Biol Med
Title: Defects in mitochondrial DNA replication and oxidative damage in muscle of mtDNA mutator mice.
Volume: 75
Pages: 241-51
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Publication
34975341 | J:322271
First Author: Wang P
Year: 2022
Journal: Int J Biol Sci
Title: DNA Polymerase Gamma Recovers Mitochondrial Function and Inhibits Vascular Calcification by Interacted with p53.
Volume: 18
Issue: 1
Pages: 409-425
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Publication
17310215 | J:122507
First Author: Lewis W
Year: 2007
Journal: Lab Invest
Title: Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma.
Volume: 87
Issue: 4
Pages: 326-35
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Publication
21332926 | J:217048
First Author: Kong YX
Year: 2011
Journal: Aging Cell
Title: Increase in mitochondrial DNA mutations impairs retinal function and renders the retina vulnerable to injury.
Volume: 10
Issue: 4
Pages: 572-83
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Publication
30990467 | J:294375
   
First Author: Woodall BP
Year: 2019
Journal: JCI Insight
Title: Parkin does not prevent accelerated cardiac aging in mitochondrial DNA mutator mice.
Volume: 5
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Publication
15888483 | J:99794
First Author: Hance N
Year: 2005
Journal: Hum Mol Genet
Title: Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis.
Volume: 14
Issue: 13
Pages: 1775-83
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HT Experiment
E-GEOD-55188 | RNA-Seq of Aged Polg Mutator Mouse Brains
Series Id: GSE55188
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein Coding Gene
MGP_CAROLIEiJ_G0029880 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032389 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032368 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032304 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032380 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032093 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1196389 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0032872 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031421 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0032059 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032214 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032169 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032295 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032206 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0032890 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031141 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031539 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013102 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0030982 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
11058962 | J:65559
First Author: Mott JL
Year: 2000
Journal: DNA Cell Biol
Title: Genomic structure of murine mitochondrial DNA polymerase-gamma.
Volume: 19
Issue: 10
Pages: 601-5
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Publication
18232733 | J:131839
First Author: Stewart JB
Year: 2008
Journal: PLoS Biol
Title: Strong purifying selection in transmission of mammalian mitochondrial DNA.
Volume: 6
Issue: 1
Pages: e10
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Publication
21311045 | J:183593
First Author: Dai DF
Year: 2011
Journal: Circ Res
Title: Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure.
Volume: 108
Issue: 7
Pages: 837-46
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Publication
17334366 | J:141666
First Author: Vermulst M
Year: 2007
Journal: Nat Genet
Title: Mitochondrial point mutations do not limit the natural lifespan of mice.
Volume: 39
Issue: 4
Pages: 540-3
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Publication
37020546 | J:345241
 
First Author: Limper CB
Year: 2023
Journal: Front Immunol
Title: Effective differentiation of double negative thymocytes requires high fidelity replication of mitochondrial DNA in an age dependent manner.
Volume: 14
Pages: 1128626
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Publication
23965628 | J:205430
First Author: Ross JM
Year: 2013
Journal: Nature
Title: Germline mitochondrial DNA mutations aggravate ageing and can impair brain development.
Volume: 501
Issue: 7467
Pages: 412-5
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Publication
23418460 | J:199416
First Author: Mito T
Year: 2013
Journal: PLoS One
Title: Mitochondrial DNA mutations in mutator mice confer respiration defects and B-cell lymphoma development.
Volume: 8
Issue: 2
Pages: e55789
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Publication
16020738 | J:99764
First Author: Kujoth GC
Year: 2005
Journal: Science
Title: Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging.
Volume: 309
Issue: 5733
Pages: 481-4
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Publication
22345551 | J:187490
First Author: Fox RG
Year: 2012
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption.
Volume: 302
Issue: 9
Pages: G914-24
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Publication
31344454 | J:293498
 
First Author: Kim MJ
Year: 2019
Journal: Exp Gerontol
Title: Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice.
Volume: 125
Pages: 110675
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Publication
32744417 | J:307644
First Author: Yang L
Year: 2020
Journal: Aging Cell
Title: Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD+ redox.
Volume: 19
Issue: 9
Pages: e13206
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Publication
33193604 | J:308311
 
First Author: Kuroki R
Year: 2020
Journal: Front Genet
Title: Establishment of Quantitative PCR Assays for Active Long Interspersed Nuclear Element-1 Subfamilies in Mice and Applications to the Analysis of Aging-Associated Retrotransposition.
Volume: 11
Pages: 519206
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Publication
26027936 | J:268294
First Author: Hämäläinen RH
Year: 2015
Journal: Cell Rep
Title: mtDNA Mutagenesis Disrupts Pluripotent Stem Cell Function by Altering Redox Signaling.
Volume: 11
Issue: 10
Pages: 1614-24
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Publication
26686024 | J:232814
First Author: Wiley CD
Year: 2016
Journal: Cell Metab
Title: Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype.
Volume: 23
Issue: 2
Pages: 303-14
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Publication
21368114 | J:170832
First Author: Safdar A
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice.
Volume: 108
Issue: 10
Pages: 4135-40
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Publication
16870370 | J:119971
First Author: Yamasoba T
Year: 2007
Journal: Hear Res
Title: Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss.
Volume: 226
Issue: 1-2
Pages: 185-93
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Publication
21664445 | J:220431
First Author: Crawley BK
Year: 2011
Journal: Hear Res
Title: Effects of mitochondrial mutations on hearing and cochlear pathology with age.
Volume: 280
Issue: 1-2
Pages: 201-8
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Publication
32669663 | J:294198
First Author: Dobson PF
Year: 2020
Journal: Sci Rep
Title: Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss.
Volume: 10
Issue: 1
Pages: 11643
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Publication
31992827 | J:294597
First Author: Geurts J
Year: 2020
Journal: Sci Rep
Title: Prematurely aging mitochondrial DNA mutator mice display subchondral osteopenia and chondrocyte hypertrophy without further osteoarthritis features.
Volume: 10
Issue: 1
Pages: 1296
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Publication
20628647 | J:163116
First Author: Hiona A
Year: 2010
Journal: PLoS One
Title: Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice.
Volume: 5
Issue: 7
Pages: e11468
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Publication
15164064 | J:91077
First Author: Trifunovic A
Year: 2004
Journal: Nature
Title: Premature ageing in mice expressing defective mitochondrial DNA polymerase.
Volume: 429
Issue: 6990
Pages: 417-23
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Publication
23090476 | J:193209
First Author: Wanrooij S
Year: 2012
Journal: EMBO Rep
Title: In vivo mutagenesis reveals that OriL is essential for mitochondrial DNA replication.
Volume: 13
Issue: 12
Pages: 1130-7
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Publication
38397399 | J:345960
 
First Author: Ross JM
Year: 2024
Journal: Biomolecules
Title: Mitochondrial Dysfunction and Protein Homeostasis in Aging: Insights from a Premature-Aging Mouse Model.
Volume: 14
Issue: 2
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Publication
32107436 | J:291764
First Author: McLaughlin KL
Year: 2020
Journal: Sci Rep
Title: Subcellular proteomics combined with bioenergetic phenotyping reveals protein biomarkers of respiratory insufficiency in the setting of proofreading-deficient mitochondrial polymerase.
Volume: 10
Issue: 1
Pages: 3603
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Publication
18311139 | J:134475
First Author: Vermulst M
Year: 2008
Journal: Nat Genet
Title: DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice.
Volume: 40
Issue: 4
Pages: 392-4
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Publication
24915468 | J:302956
 
First Author: Baines HL
Year: 2014
Journal: Mech Ageing Dev
Title: Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans.
Volume: 139
Pages: 22-30
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Publication
30217445 | J:272110
First Author: McLaughlin KL
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Bioenergetic consequences of compromised mitochondrial DNA repair in the mouse heart.
Volume: 504
Issue: 4
Pages: 742-748
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Publication
19656491 | J:151969
First Author: Edgar D
Year: 2009
Journal: Cell Metab
Title: Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice.
Volume: 10
Issue: 2
Pages: 131-8
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Publication
28699890 | J:256955
   
First Author: Brandt T
Year: 2017
Journal: Elife
Title: Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila.
Volume: 6
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Publication
34143518 | J:314532
First Author: Lv M
Year: 2021
Journal: FASEB J
Title: Adipose-derived stem cells regulate metabolic homeostasis and delay aging by promoting mitophagy.
Volume: 35
Issue: 7
Pages: e21709
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Publication
22988144 | J:203020
First Author: Yamada T
Year: 2012
Journal: J Physiol
Title: Impaired mitochondrial respiration and decreased fatigue resistance followed by severe muscle weakness in skeletal muscle of mitochondrial DNA mutator mice.
Volume: 590
Issue: 23
Pages: 6187-97
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Publication
23042113 | J:190382
First Author: Freyer C
Year: 2012
Journal: Nat Genet
Title: Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission.
Volume: 44
Issue: 11
Pages: 1282-5
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Publication
29601571 | J:261916
First Author: Forslund JME
Year: 2018
Journal: PLoS Genet
Title: The presence of rNTPs decreases the speed of mitochondrial DNA replication.
Volume: 14
Issue: 3
Pages: e1007315
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Publication
21455489 | J:332742
First Author: Ameur A
Year: 2011
Journal: PLoS Genet
Title: Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins.
Volume: 7
Issue: 3
Pages: e1002028
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Publication
16332961 | J:104391
First Author: Trifunovic A
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production.
Volume: 102
Issue: 50
Pages: 17993-8
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Publication
17662273 | J:145126
First Author: Niu X
Year: 2007
Journal: Exp Cell Res
Title: Somatic mtDNA mutations cause progressive hearing loss in the mouse.
Volume: 313
Issue: 18
Pages: 3924-34
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Publication
24985350 | J:302961
First Author: Li L
Year: 2014
Journal: Diabetes
Title: Defects in β-cell Ca2+ dynamics in age-induced diabetes.
Volume: 63
Issue: 12
Pages: 4100-14
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Publication
23850316 | J:202707
First Author: Xu X
Year: 2013
Journal: Cell Metab
Title: Mitochondrial regulation in pluripotent stem cells.
Volume: 18
Issue: 3
Pages: 325-32
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Publication
25511702 | J:220366
First Author: Mito T
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Transmitochondrial mito-miceΔ and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders.
Volume: 456
Issue: 4
Pages: 933-7
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Publication
23090637 | J:192187
First Author: Koczor CA
Year: 2013
Journal: Lab Invest
Title: Transgenic mouse model with deficient mitochondrial polymerase exhibits reduced state IV respiration and enhanced cardiac fibrosis.
Volume: 93
Issue: 2
Pages: 151-8
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Publication
26095671 | J:343123
 
First Author: Macao B
Year: 2015
Journal: Nat Commun
Title: The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication.
Volume: 6
Pages: 7303
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Publication
11031098 | J:65542
First Author: Zhang D
Year: 2000
Journal: Genomics
Title: Construction of transgenic mice with tissue-specific acceleration of mitochondrial DNA mutagenesis.
Volume: 69
Issue: 2
Pages: 151-61
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