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Search results 101 to 125 out of 125 for Mon2

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Type Details Score
Protein Domain
IPR032629 | DCB_dom
Type: Domain
Description: This is theN-terminal domain of Mon2- and BIG1-like proteins, the dimerisation and cyclophilin-binding domain (DCB) [, ]. The N terminus of Mon2 (Ysl2) binds to Arf-Like small GTPase Arl1, and shows homology to brefeldin A-inhibited guanine-exchange factor (BIG) domains []. Mon2 and BIG1-like proteins play an important role in membrane traffic and Golgi homeostasis [, , ]. This domain is sufficient for targeting BIG1 to the Golgi.
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Protein
Q3TTT0
Organism: Mus musculus/domesticus
Length: 436  
Fragment?: false
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Publication
16301316 | -
First Author: Gillingham AK
Year: 2006
Journal: J Biol Chem
Title: Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus.
Volume: 281
Issue: 4
Pages: 2273-80
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Protein
A0JLN9
Organism: Mus musculus/domesticus
Length: 551  
Fragment?: true
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Publication
23386609 | -
First Author: Lowery J
Year: 2013
Journal: J Biol Chem
Title: The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).
Volume: 288
Issue: 16
Pages: 11532-45
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Protein Domain
IPR032691 | Mon2/Sec7/BIG1-like_HUS
Type: Domain
Description: This entry represent the HUS regulatory domain found towards the N terminus in guanine nucleotide exchange factors involved Golgi transport, such as budding yeast protein Sec7, protein Mon2 and BIG1-like proteins [, ].Sec7 and its homologues are guanine nucleotide exchange factors (GEFs) involved in the secretory pathway []. The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI []. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF [].Mon2 is distantly related to the Arf1 guanine nucleotide exchange factors (GEFs), such as Sec7. However, it lacks the Sec7 domain that catalyses nucleotide exchange on Arf1. Instead, Mon2 acts as a scaffold to recruit the Golgi-localised pool of Dop1 [].
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Publication
11208097 | -
First Author: Deitz SB
Year: 2000
Journal: Traffic
Title: Sec7p directs the transitions required for yeast Golgi biogenesis.
Volume: 1
Issue: 2
Pages: 172-83
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Publication
27373159 | -
First Author: Galindo A
Year: 2016
Journal: Cell Rep
Title: Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi.
Volume: 16
Issue: 3
Pages: 839-50
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Protein Domain
IPR015403 | Mon2/Sec7/BIG1-like_HDS
Type: Domain
Description: This entry represents a HDS (homology downstream of Sec7) domain found towards the C-terminal of guanine nucleotide exchange factors involved Golgi transport, such as budding yeast protein Sec7, protein Mon2 and BIG1-like proteins [, ]. Sec7 is involved in the secretory pathway as a protein binding scaffold for the COPII-COPI protein switch for maturation of the VTC intermediate compartments for Golgi compartment biogenesis []. Sec7 has four conserved HDS1-4 domains which act to integrate the signals from several small GTPases, including Arf1 itself, to switch Sec7 from a strongly autoinhibited to a strongly auto activated form [].
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Publication
3042778 | -
First Author: Achstetter T
Year: 1988
Journal: J Biol Chem
Title: SEC7 encodes an unusual, high molecular weight protein required for membrane traffic from the yeast Golgi apparatus.
Volume: 263
Issue: 24
Pages: 11711-7
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Publication
26765562 | -
   
First Author: Richardson BC
Year: 2016
Journal: Elife
Title: The Sec7 N-terminal regulatory domains facilitate membrane-proximal activation of the Arf1 GTPase.
Volume: 5
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Protein
Q3UGY8
Organism: Mus musculus/domesticus
Length: 2170  
Fragment?: false
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Protein
A0A1N9M5I8
Organism: Mus musculus/domesticus
Length: 1709  
Fragment?: false
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Protein
Q8BYH5
Organism: Mus musculus/domesticus
Length: 747  
Fragment?: true
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Protein
G3X9K3
Organism: Mus musculus/domesticus
Length: 1846  
Fragment?: false
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Protein
A2A5R2
Organism: Mus musculus/domesticus
Length: 1792  
Fragment?: false
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Protein
Q3UPP2
Organism: Mus musculus/domesticus
Length: 817  
Fragment?: false
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Protein
D3YYK9
Organism: Mus musculus/domesticus
Length: 1054  
Fragment?: false
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Protein
Q3U5C3
Organism: Mus musculus/domesticus
Length: 794  
Fragment?: true
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Protein
Q6A099
Organism: Mus musculus/domesticus
Length: 1803  
Fragment?: true
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Protein
Q6DFZ1
Organism: Mus musculus/domesticus
Length: 1861  
Fragment?: false
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Protein
Q3U2F2
Organism: Mus musculus/domesticus
Length: 1050  
Fragment?: true
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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