|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 401 to 479 out of 479 for Hspb8

<< First    < Previous  |  Next >    Last >>
0.023s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Publication
21914495 | J:189494
First Author: Cui XY
Year: 2012
Journal: Exp Hematol
Title: HSPB8 is methylated in hematopoietic malignancies and overexpression of HSPB8 exhibits antileukemia effect.
Volume: 40
Issue: 1
Pages: 14-21
•
•
•
•
•
Publication
35148379 | J:338997
First Author: Jennings MJ
Year: 2022
Journal: Brain
Title: NCAM1 and GDF15 are biomarkers of Charcot-Marie-Tooth disease in patients and mice.
Volume: 145
Issue: 11
Pages: 3999-4015
•
•
•
•
•
Publication
21747053 | J:186292
First Author: Qiu H
Year: 2011
Journal: Circulation
Title: H11 kinase/heat shock protein 22 deletion impairs both nuclear and mitochondrial functions of STAT3 and accelerates the transition into heart failure on cardiac overload.
Volume: 124
Issue: 4
Pages: 406-15
•
•
•
•
•
Publication
9383292 | J:39563
First Author: Welch CL
Year: 1997
Journal: Mamm Genome
Title: Srb1 maps to mouse chromosome 5 in a region harboring putative QTLs for plasma lipoprotein levels.
Volume: 8
Issue: 12
Pages: 942-4
•
•
•
•
•
Publication
11714668 | J:73524
First Author: Dimanlig PV
Year: 2001
Journal: Development
Title: The upstream ectoderm enhancer in Pax6 has an important role in lens induction.
Volume: 128
Issue: 22
Pages: 4415-24
•
•
•
•
•
Publication
17661394 | J:125325
First Author: Huang L
Year: 2007
Journal: Genesis
Title: Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption.
Volume: 45
Issue: 8
Pages: 487-501
•
•
•
•
•
Publication
12439624 | J:80918
First Author: Smith JB
Year: 2002
Journal: Immunogenetics
Title: Cloning and genomic localization of the murine LPS-induced CXC chemokine (LIX) gene, Scyb5.
Volume: 54
Issue: 8
Pages: 599-603
•
•
•
•
•
Publication
33742095 | J:305082
First Author: Pathak P
Year: 2021
Journal: Commun Biol
Title: Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCĪ± and TSC2-mTOR downregulation.
Volume: 4
Issue: 1
Pages: 355
•
•
•
•
•
Publication
18675797 | J:141960
First Author: Swindell EC
Year: 2008
Journal: Dev Biol
Title: Eye formation in the absence of retina.
Volume: 322
Issue: 1
Pages: 56-64
•
•
•
•
•
Publication
10603348 | J:56583
First Author: Ring BZ
Year: 2000
Journal: Development
Title: Regulation of mouse lens fiber cell development and differentiation by the Maf gene.
Volume: 127
Issue: 2
Pages: 307-17
•
•
•
•
•
Publication
9321482 | J:36975
First Author: Klingenspor M
Year: 1997
Journal: Mamm Genome
Title: Localization of ubiquitin gene family members to mouse chromosomes 5, 11, and 18.
Volume: 8
Issue: 10
Pages: 789-90
•
•
•
•
•
Publication
17366632 | J:119481
First Author: Ramakrishna S
Year: 2007
Journal: Dev Dyn
Title: Myocardium defects and ventricular hypoplasia in mice homozygous null for the Forkhead Box M1 transcription factor.
Volume: 236
Issue: 4
Pages: 1000-13
•
•
•
•
•
Publication
10438476 | J:42314
First Author: Klingenspor M
Year: 1999
Journal: J Biol Chem
Title: Altered gene expression pattern in the fatty liver dystrophy mouse reveals impaired insulin-mediated cytoskeleton dynamics.
Volume: 274
Issue: 33
Pages: 23078-84
•
•
•
•
•
Publication
23055939 | J:193641
First Author: Nakano Y
Year: 2012
Journal: PLoS Genet
Title: A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse.
Volume: 8
Issue: 10
Pages: e1002966
•
•
•
•
•
Publication
8288233 | J:15567
First Author: Warden CH
Year: 1993
Journal: Genomics
Title: Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse.
Volume: 18
Issue: 2
Pages: 295-307
•
•
•
•
•
Publication
11591653 | J:103507
First Author: Suzuki H
Year: 2001
Journal: Genome Res
Title: Protein-protein interaction panel using mouse full-length cDNAs.
Volume: 11
Issue: 10
Pages: 1758-65
•
•
•
•
•
Publication
8827514 | J:34178
First Author: Welch CL
Year: 1996
Journal: J Lipid Res
Title: Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes.
Volume: 37
Issue: 7
Pages: 1406-21
•
•
•
•
•
Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
•
•
•
•
•
Publication
- | J:66660
       
First Author: Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration
Year: 2001
Title: LocusLink Collaboration
•
•
•
•
•
Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
•
•
•
•
•
Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
•
•
•
•
•
Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
•
•
•
•
•
Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
•
•
•
•
•
Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
•
•
•
•
•
Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
•
•
•
•
•
Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
•
•
•
•
•
Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
•
•
•
•
•
Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
•
•
•
•
•
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
•
•
•
•
•
Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
•
•
•
•
•
Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
•
•
•
•
•
Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
•
•
•
•
•
Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
•
•
•
•
•
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
•
•
•
•
•
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
•
•
•
•
•
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
•
•
•
•
•
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
•
•
•
•
•
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
19399179 | J:148261
First Author: Sanbe A
Year: 2009
Journal: PLoS One
Title: Protective effect of geranylgeranylacetone via enhancement of HSPB8 induction in desmin-related cardiomyopathy.
Volume: 4
Issue: 4
Pages: e5351
•
•
•
•
•
Publication
27466192 | J:238573
First Author: Crippa V
Year: 2016
Journal: Hum Mol Genet
Title: The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity.
Volume: 25
Issue: 18
Pages: 3908-3924
•
•
•
•
•
Publication
18006506 | -
First Author: Carra S
Year: 2008
Journal: J Biol Chem
Title: HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy.
Volume: 283
Issue: 3
Pages: 1437-44
•
•
•
•
•
Publication
18094623 | -
First Author: Carra S
Year: 2008
Journal: Autophagy
Title: HspB8 and Bag3: a new chaperone complex targeting misfolded proteins to macroautophagy.
Volume: 4
Issue: 2
Pages: 237-9
•
•
•
•
•
Allele
Hspb8<em1Smoc> | MGI:7290271
Name: heat shock protein 8; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
DO Term
DOID:0110174 | Charcot-Marie-Tooth disease axonal type 2L
•
•
•
•
•
Strain
MGI:6475520 | C57BL/6-Hspb8<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Publication
11470154 | -
First Author: KappƩ G
Year: 2001
Journal: Biochim Biophys Acta
Title: Characterization of two novel human small heat shock proteins: protein kinase-related HspB8 and testis-specific HspB9.
Volume: 1520
Issue: 1
Pages: 1-6
•
•
•
•
•
Allele
Tg(Hspb8-EGFP)HI62Gsat | MGI:4847145
Name: transgene insertion HI62, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
•
•
•
•
•
Publication
17304582 | -
First Author: Hu Z
Year: 2007
Journal: J Neurosci Res
Title: Structure, function, property, and role in neurologic diseases and other diseases of the sHsp22.
Volume: 85
Issue: 10
Pages: 2071-9
•
•
•
•
•
Publication
18832141 | -
First Author: Houlden H
Year: 2008
Journal: Neurology
Title: Mutations in the HSP27 (HSPB1) gene cause dominant, recessive, and sporadic distal HMN/CMT type 2.
Volume: 71
Issue: 21
Pages: 1660-8
•
•
•
•
•
Publication
23796487 | -
First Author: Nakhro K
Year: 2013
Journal: Neuromuscul Disord
Title: A novel Lys141Thr mutation in small heat shock protein 22 (HSPB8) gene in Charcot-Marie-Tooth disease type 2L.
Volume: 23
Issue: 8
Pages: 656-63
•
•
•
•
•
Publication
17718384 | -
First Author: Laskowska E
Year: 2007
Journal: Postepy Biochem
Title: [Small heat shock proteins--role in apoptosis, cancerogenesis and diseases associated with protein aggregation].
Volume: 53
Issue: 1
Pages: 19-26
•
•
•
•
•
Publication
22521623 | -
First Author: Acunzo J
Year: 2012
Journal: Int J Biochem Cell Biol
Title: Small heat shock proteins HSP27 (HspB1), Ī±B-crystallin (HspB5) and HSP22 (HspB8) as regulators of cell death.
Volume: 44
Issue: 10
Pages: 1622-31
•
•
•
•
•
Protein Domain
IPR042790 | HspB8_ACD
Type: Domain
Description: This entry represents the alpha-crystallin domain (ACD) found in mammalian 21.6 kDa small heat shock protein (sHsp) HspB8, also known as Hsp22 in humans []. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits []. A chaperone complex formed of HspB8 and Bag3 stimulates degradation of protein complexes by macroautophagy [, ]. HspB8 also forms complexes with Hsp27 (HspB1), MKBP (HspB2), HspB3, alphaB-crystallin (HspB5), Hsp20 (HspB6), and cvHsp (HspB7). These latter interactions may depend on phosphorylation of the respective partner sHsp. HspB8 may participate in the regulation of cell proliferation, cardiac hypertrophy, apoptosis, and carcinogenesis [, ].Point mutations in HspB8 have been correlated with the development of several congenital neurological diseases, including Charcot Marie tooth disease and distal motor neuropathy type II [, ].
•
•
•
•
•
Strain
MGI:5003723 | STOCK Tg(Hspb8-EGFP)HI62Gsat/Mmucd
Attribute String: mutant stock, transgenic
•
•
•
•
•
Publication
31273097 | J:276778
 
First Author: Abdel-Nour M
Year: 2019
Journal: Science
Title: The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling.
Volume: 365
Issue: 6448
•
•
•
•
•
Publication
21423662 | J:171699
First Author: Hishiya A
Year: 2011
Journal: PLoS One
Title: BAG3 directly interacts with mutated alphaB-crystallin to suppress its aggregation and toxicity.
Volume: 6
Issue: 3
Pages: e16828
•
•
•
•
•
Publication
34117258 | J:322193
First Author: Kimura K
Year: 2021
Journal: Nat Commun
Title: Overexpression of human BAG3P209L in mice causes restrictive cardiomyopathy.
Volume: 12
Issue: 1
Pages: 3575
•
•
•
•
•
Publication
26490709 | J:254480
 
First Author: Rusmini P
Year: 2015
Journal: Sci Rep
Title: Aberrant Autophagic Response in The Muscle of A Knock-in Mouse Model of Spinal and Bulbar Muscular Atrophy.
Volume: 5
Pages: 15174
•
•
•
•
•
Publication
27567740 | J:236781
 
First Author: La Padula V
Year: 2016
Journal: Exp Neurol
Title: HSPB3 protein is expressed in motoneurons and induces their survival after lesion-induced degeneration.
Volume: 286
Pages: 40-49
•
•
•
•
•
Publication
24324403 | J:313658
 
First Author: Crippa V
Year: 2013
Journal: Front Cell Neurosci
Title: Differential autophagy power in the spinal cord and muscle of transgenic ALS mice.
Volume: 7
Pages: 234
•
•
•
•
•
Publication
29187369 | J:283129
First Author: Nie X
Year: 2018
Journal: Am J Physiol Renal Physiol
Title: Pharmacological and genetic inhibition of downstream targets of p38 MAPK in experimental nephrotic syndrome.
Volume: 314
Issue: 4
Pages: F602-F613
•
•
•
•
•
Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom