Type |
Details |
Score |
Allele |
Name: |
VPS50 EARP/GARPII complex subunit; gene trap E285A07, German Gene Trap Consortium |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS50 EARP/GARPII complex subunit; gene trap E155E07, German Gene Trap Consortium |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS50 EARP/GARPII complex subunit; endonuclease-mediated mutation 1, Center for Animal Resources and Development |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
VPS50 EARP/GARPII complex subunit; gene trap M068F02, German Gene Trap Consortium |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS50 EARP/GARPII complex subunit; gene trap EUCE00176d03, Helmholtz Zentrum Muenchen GmbH |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
929
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
938
|
Fragment?: |
false |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents a domain found in vacuolar protein sorting-associated protein 54 (VPS54), which acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). VPS54 is required to tether the complex to the TGN. However, it is not involved in endocytic recycling [].Proteins containing this domain also includes VPS50 (also known as Syndetin), which is a component of the EARP complex that is involved in endocytic recycling. It is required to tether the EARP complex to recycling endosomes. Nevertheless, it is involved in retrograde transport from early and late endosomes to the TGN []. |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Brien CE |
Year: |
2023 |
Journal: |
J Cell Biol |
Title: |
The GARP complex prevents sterol accumulation at the trans-Golgi network during dendrite remodeling. |
Volume: |
222 |
Issue: |
1 |
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
977
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
977
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
815
|
Fragment?: |
true |
|
•
•
•
•
•
|