Fanconi anemia (FA) is a human disorder characterized by cancer susceptibility and cellular sensitivity to DNA crosslinks and other damages. The FA complex repairs the interstrand cross-linking (ICL) lesions and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination. It is required for the monoubiquitylation of FANCD2 and FANCI heterodimer. The FA core complex consists of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FANCT (UBET2), FAAP100 and FAAP24 [, ].This entry represents FANCA [].
This domain is found in the N-terminal of Fanconi anemia-associated protein of 20kDa (FAAP20), where it is responsible for interaction with Fanconi anemia group A protein (FANCA) [].The Fanconi anemia (FA) pathway participates in interstrand cross-link repair and the maintenance of genomic stability. FAAP20 is a component of the FA core complex.
