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Search results 101 to 115 out of 115 for Rae1

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Type

Details

Score

Protein Domain

IPR037631 | Gle2/RAE1

Type:

Family

Description:

This entry includes nucleoporin Gle2, a component of the nuclear pore complex (NPC) in the yeast Saccharomyces cerevisiae. The NPC is the only means by which macromolecules enter and exit the nucleus. Gle2 is important for mRNA export []. In Schizosaccharomyces pombe and chordates, Gle2 is known as RAE1. RAE1 interaction with NuMA is required for bipolar spindle formation []. RAE1 acts as a mRNA export factor involved in nucleocytoplasmic transport [].

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Publication

16310783 | -

First Author:	Geng H
Year:	2005
Journal:	FEBS Lett
Title:	The putative protein 6 of the severe acute respiratory syndrome-associated coronavirus: expression and functional characterization.
Volume:	579
Issue:	30
Pages:	6763-8

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Publication

25907116 | -

First Author:	Cheng W
Year:	2015
Journal:	Virol Sin
Title:	Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal degradation of N-Myc (and STAT) interactor.
Volume:	30
Issue:	2
Pages:	153-61

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Protein Domain

IPR022736 | NS6_bCoV

Type:

Family

Description:

This entry represents the non-structural protein NS6 (also known as ORF6, accessory protein 6, or X3 protein), which is highly conserved among SARS-related coronaviruses [](this is distinct from NSP6 which is encoded on the replicase polyprotein). NS6 is located in the endoplasmic reticulum []. It has been reported that NS6 can increase the cellular gene synthesis and it can also induce apoptosis through Jun N-terminal kinase and Caspase-3 mediated stress. This protein can modulate host antiviral responses by inhibiting synthesis and signalling of interferon-beta (IFN-beta) via two complementary pathways. One involves NS6 interaction with host N-Myc (and STAT) interactor (Nmi) protein inducing its degradation via ubiquitin proteasome pathway, suppressing Nmi enhanced IFN signalling. The other pathway suppresses the translocation of signal transducer and activator of transcription 1 (STAT1) and downstream IFN signalling [].This protein interacts with Rae1 and Nup98 to prevent both nuclear import and export, which renders host cells incapable of responding to SARS-CoV-2 infection [].

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Publication

22244846 | J:181185

First Author:	Markiewicz MA
Year:	2012
Journal:	Immunity
Title:	RAE1ε ligand expressed on pancreatic islets recruits NKG2D receptor-expressing cytotoxic T cells independent of T cell receptor recognition.
Volume:	36
Issue:	1
Pages:	132-41

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Publication

23355740 | J:193469

First Author:	Zhang T
Year:	2013
Journal:	J Immunol
Title:	Mouse tumor vasculature expresses NKG2D ligands and can be targeted by chimeric NKG2D-modified T cells.
Volume:	190
Issue:	5
Pages:	2455-63

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Publication

12645935 | J:82077

First Author:	Diefenbach A
Year:	2003
Journal:	Eur J Immunol
Title:	A novel ligand for the NKG2D receptor activates NK cells and macrophages and induces tumor immunity.
Volume:	33
Issue:	2
Pages:	381-91

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Publication

17463084 | J:121349

First Author:	Zhou R
Year:	2007
Journal:	Proc Natl Acad Sci U S A
Title:	NKG2D recognition mediates Toll-like receptor 3 signaling-induced breakdown of epithelial homeostasis in the small intestines of mice.
Volume:	104
Issue:	18
Pages:	7512-5

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Publication

11042159 | J:68323

First Author:	Carninci P
Year:	2000
Journal:	Genome Res
Title:	Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Volume:	10
Issue:	10
Pages:	1617-30

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Publication

10349636 | J:80645

First Author:	Carninci P
Year:	1999
Journal:	Methods Enzymol
Title:	High-efficiency full-length cDNA cloning.
Volume:	303

Pages:	19-44

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Publication

11076861 | J:68324

First Author:	Shibata K
Year:	2000
Journal:	Genome Res
Title:	RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Volume:	10
Issue:	11
Pages:	1757-71

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Publication

16141073 | -

First Author:	Katayama S
Year:	2005
Journal:	Science
Title:	Antisense transcription in the mammalian transcriptome.
Volume:	309
Issue:	5740
Pages:	1564-6

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Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

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Publication

21183079 | J:292518

First Author:	Huttlin EL
Year:	2010
Journal:	Cell
Title:	A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume:	143
Issue:	7
Pages:	1174-89

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Publication

19468303 | -

First Author:	Church DM
Year:	2009
Journal:	PLoS Biol
Title:	Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume:	7
Issue:	5
Pages:	e1000112

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