Tubulin polymerisation-promoting protein family member 2 (TPPP2, also known as p18) belongs to the TPPP family []. The function of TPPP2 is not clear. It may bind tubulin but has no microtubule bundling activity [].
Tubulin polymerisation-promoting protein family member 3 (TPPP3, also known as p20) belongs to the TPPP family []. It is an intrinsically unstructured protein that induces tubulin polymerisation. It attaches to microtubules (MTs) causing MT bundling both in vitro and in vivo []. It is involved in developmental processes of the musculoskeletal system [].
TPPP1 (also known as TPPP/p25) belongs to the TPPP (tubulin polymerisation promoting protein) family []. TPPP/p25 binds to tubulins and cause microtubules (MT) bundling both in vitro and in vivo []. It promotes tubulin acetylation by inhibiting histone deacetylase 6 []. Its ability of assemble MTs can be inhibited by LIM kinase []. Rho-associated coiled-coil kinase (Rock) and Cdk phosphorylation of TPPP/p25 inhibits its regulation of the cell cycle to increase cell proliferation [].
