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Search results 101 to 179 out of 179 for Pot1a

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Type Details Score
GXD Expression
GXD Expression
     
Probe: MGI:7266332
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:7266400
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266332
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:7266400
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266332
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:7266400
Age: postnatal day 7
Specimen Label: P7
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266332
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:7266400
Age: postnatal day 21
Specimen Label: P21
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266332
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:7266400
Age: postnatal day 100
Specimen Label: P100
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266332
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684616
Stage: TS16
Assay Id: MGI:7266408
Age: embryonic day 10.0
Specimen Label: E10
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266332
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684620
Stage: TS20
Assay Id: MGI:7266408
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266332
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:7266408
Age: embryonic day 14.0
Specimen Label: E14
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266332
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:7266408
Age: embryonic day 16.0
Specimen Label: E16
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266332
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:7266408
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266332
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:7266408
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266332
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:7266408
Age: postnatal day 7
Specimen Label: P7
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266332
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:7266408
Age: postnatal day 21
Specimen Label: P21
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266332
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:7266408
Age: postnatal day 100
Specimen Label: P100
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266332
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1636716
Stage: TS16
Assay Id: MGI:7266416
Age: embryonic day 10.0
Specimen Label: E10
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266332
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737320
Stage: TS20
Assay Id: MGI:7266416
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266332
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737322
Stage: TS22
Assay Id: MGI:7266416
Age: embryonic day 14.0
Specimen Label: E14
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266332
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737324
Stage: TS24
Assay Id: MGI:7266416
Age: embryonic day 16.0
Specimen Label: E16
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266332
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737326
Stage: TS26
Assay Id: MGI:7266416
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266332
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737327
Stage: TS27
Assay Id: MGI:7266416
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266332
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:7266416
Age: postnatal day 7
Specimen Label: P7
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266332
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:7266416
Age: postnatal day 21
Specimen Label: P21
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266332
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:7266416
Age: postnatal day 100
Specimen Label: P100
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691023
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_01
Specimen Label: euxassay_000324_01
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3692958
Age: embryonic day 13.5
Note: There is near ubiquitous expression during embryonic development.
Specimen Label: side view
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3692958
Age: embryonic day 13.5
Note: There is near ubiquitous expression during embryonic development.
Specimen Label: frontal view
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3692958
Age: embryonic day 13.5
Note: There is near ubiquitous expression during embryonic development.
Specimen Label: dorsal view
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1759623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_23
Specimen Label: euxassay_000324_23
Detected: true
Specimen Num: 19
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_01
Specimen Label: euxassay_000324_01
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_02
Specimen Label: euxassay_000324_02
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_03
Specimen Label: euxassay_000324_03
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_04
Specimen Label: euxassay_000324_04
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_05
Specimen Label: euxassay_000324_05
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_06
Specimen Label: euxassay_000324_06
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_07
Specimen Label: euxassay_000324_07
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_09
Specimen Label: euxassay_000324_09
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_10
Specimen Label: euxassay_000324_10
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_11
Specimen Label: euxassay_000324_11
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_15
Specimen Label: euxassay_000324_15
Detected: true
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_16
Specimen Label: euxassay_000324_16
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_17
Specimen Label: euxassay_000324_17
Detected: true
Specimen Num: 13
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_18
Specimen Label: euxassay_000324_18
Detected: true
Specimen Num: 14
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_19
Specimen Label: euxassay_000324_19
Detected: true
Specimen Num: 15
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_20
Specimen Label: euxassay_000324_20
Detected: true
Specimen Num: 16
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_21
Specimen Label: euxassay_000324_21
Detected: true
Specimen Num: 17
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_22
Specimen Label: euxassay_000324_22
Detected: true
Specimen Num: 18
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1870623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_21
Specimen Label: euxassay_000324_21
Detected: true
Specimen Num: 17
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1870623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_22
Specimen Label: euxassay_000324_22
Detected: true
Specimen Num: 18
•
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•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
23965306 | J:210719
First Author: Chen HY
Year: 2013
Journal: Nucleic Acids Res
Title: DAZAP1 regulates the splicing of Crem, Crisp2 and Pot1a transcripts.
Volume: 41
Issue: 21
Pages: 9858-69
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Protein
Q91WC1
Organism: Mus musculus/domesticus
Length: 640  
Fragment?: false
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•
•
•
Protein
Q91WC1-2
Organism: Mus musculus/domesticus
Length: 538  
Fragment?: false
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Publication
25329641 | -
First Author: Renfrew KB
Year: 2014
Journal: PLoS Genet
Title: POT1a and components of CST engage telomerase and regulate its activity in Arabidopsis.
Volume: 10
Issue: 10
Pages: e1004738
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Publication
20493859 | -
First Author: Baumann P
Year: 2010
Journal: FEBS Lett
Title: Pot1 and telomere maintenance.
Volume: 584
Issue: 17
Pages: 3779-84
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Publication
15637058 | -
First Author: Trujillo KM
Year: 2005
Journal: J Biol Chem
Title: Extended DNA binding site in Pot1 broadens sequence specificity to allow recognition of heterogeneous fission yeast telomeres.
Volume: 280
Issue: 10
Pages: 9119-28
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Publication
17627276 | -
First Author: Surovtseva YV
Year: 2007
Journal: EMBO J
Title: Arabidopsis POT1 associates with the telomerase RNP and is required for telomere maintenance.
Volume: 26
Issue: 15
Pages: 3653-61
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Publication
23181431 | -
First Author: Wu Y
Year: 2013
Journal: J Proteome Res
Title: Novel phosphorylation sites in the S. cerevisiae Cdc13 protein reveal new targets for telomere length regulation.
Volume: 12
Issue: 1
Pages: 316-27
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Protein Domain
IPR028389 | POT1
Type: Family
Description: In most eukaryotes, their chromosome ends are composed of a single stranded overhang that contains GT-rich repeats and are bound by telomerase ribonucleoproteins (RNPs).This entry represents a group of telomere binding proteins, including the protection of telomeres protein 1 (POT1) from humans/fission yeast/plants, the telomere end binding proteins (TEBP) alpha from the hypotrichous ciliate Oxytricha nova and Cdc13 from Saccharomyces cerevisiae. They are ribonucleoproteins (RNPs) that play an important role in telomere maintenance, but the precise roles played in end protection and telomere length regulation seem to vary considerably between organisms [, ]. In fission yeast, POT1 prevents access of telomerase to the 3'-end and protects against exonucleolytic degradation []. However, in humans, POT1 might function predominantly in telomere length regulation rather than in the protection of telomeres []. In Arabidopsis, there are several POT-like proteins, including POT1a, POT1b and POT1c []. POT1a and POT1b are components of telomerase rather than telomere capping components []. In Saccharomyces cerevisiae an OB-fold containing protein called Cdc13 plays a similar role as POT1, such as single-stranded G-rich telomeric DNA binding and telomere maintenance [, ].
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Publication
37560909 | J:340807
First Author: Takasugi T
Year: 2023
Journal: Nucleic Acids Res
Title: Pot1b -/- tumors activate G-quadruplex-induced DNA damage to promote telomere hyper-elongation.
Volume: 51
Issue: 17
Pages: 9227-9247
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Protein
A0A3B2WCG4
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: true
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Protein
H7BX60
Organism: Mus musculus/domesticus
Length: 640  
Fragment?: false
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•
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•
Protein
A0A3B2WCZ2
Organism: Mus musculus/domesticus
Length: 352  
Fragment?: false
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•
Protein
Q3UVD7
Organism: Mus musculus/domesticus
Length: 538  
Fragment?: false
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•
•
•
•
Protein
Q3TNS5
Organism: Mus musculus/domesticus
Length: 623  
Fragment?: false
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•
•
Protein
Q3UXR7
Organism: Mus musculus/domesticus
Length: 325  
Fragment?: false
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•
Publication
18535244 | -
First Author: Miyoshi T
Year: 2008
Journal: Science
Title: Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length.
Volume: 320
Issue: 5881
Pages: 1341-4
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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