Clathrin interactor 1 (CLINT1, also known as EpsinR) promotes Clathrin-coated vesicle formation at the trans-Golgi network and endosomes and thereby modulates Golgi-endosome trafficking []. It binds to the SNARE Protein vti1b []. Interestingly, one isoform of Drosophila EpsinR is a translational fusion with the only Tel2 coding sequences in Drosophila. In this fusion protein, Tel2 serves as a regulator of wingless signalling []. Human EpsinR is involved in endogenous MHC-II-restricted antigen presentation [].
