SWI/SNF complex subunit SMARCC2 (SMARCC2 or BAF170) is a component of several complexes that remodel chromatin, a mechanism by which selected genes are transcriptionally activated or repressed. The complexes are SWI/SNF (A and B), which changes chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner []; BAF []; and the npBAF and nBAF, which are neuron-specific []. SMARCC2 also interacts with proteins such as SMARD1 []and RCOR1 [].
This entry represents the N-terminal conserved domain found in the SWI/SNF complex subunits SMARCC1 (BAF155) and SMARCC2 (BAF170). The function of this domain is not clear.
This conserved domain can be found after the SWIRM and SANT domains in SWI/SNFcomplex subunits SMARCC1 (BAF155) and SMARCC2 (BAF170) []. The function of this domain is not clear.
