TRIM proteins are E3 ubiquitin ligases defined by the presence of the tripartite motif RING/B-box/coiled-coil region, and are also known as RBCC proteins. While the tripartite motif is restricted to this protein family, the C-terminal domains can vary and are also present in otherwise unrelated proteins [].This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C terminus of TRIM46. TRIM46 is required for neuronal polarization and axon formation. It localizes to the newly specified axon and organizes uniform microtubule orientation in axons [].
