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Search results 101 to 200 out of 200 for Erc1

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0.037s
Type Details Score
Publication
First Author: Matkovic T
Year: 2013
Journal: J Cell Biol
Title: The Bruchpilot cytomatrix determines the size of the readily releasable pool of synaptic vesicles.
Volume: 202
Issue: 4
Pages: 667-83
Publication
First Author: Hagiwara A
Year: 2018
Journal: J Cell Biol
Title: Cytomatrix proteins CAST and ELKS regulate retinal photoreceptor development and maintenance.
Volume: 217
Issue: 11
Pages: 3993-4006
Publication
First Author: Ohara-Imaizumi M
Year: 2019
Journal: Cell Rep
Title: ELKS/Voltage-Dependent Ca2+ Channel-β Subunit Module Regulates Polarized Ca2+ Influx in Pancreatic β Cells.
Volume: 26
Issue: 5
Pages: 1213-1226.e7
Publication
First Author: Mochida S
Year: 2016
Journal: Cell Rep
Title: SAD-B Phosphorylation of CAST Controls Active Zone Vesicle Recycling for Synaptic Depression.
Volume: 16
Issue: 11
Pages: 2901-2913
Publication
First Author: Kawabe H
Year: 2017
Journal: J Cell Biol
Title: ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones.
Volume: 216
Issue: 4
Pages: 1143-1161
Publication
First Author: Wang SSH
Year: 2016
Journal: Neuron
Title: Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking.
Volume: 91
Issue: 4
Pages: 777-791
Publication
First Author: Nyitrai H
Year: 2020
Journal: Cell Rep
Title: ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals.
Volume: 31
Issue: 10
Pages: 107712
Publication
First Author: Dong W
Year: 2018
Journal: Cell Rep
Title: CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse.
Volume: 24
Issue: 2
Pages: 284-293.e6
Publication
First Author: Wu ZH
Year: 2010
Journal: Mol Cell
Title: ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress.
Volume: 40
Issue: 1
Pages: 75-86
Publication
First Author: Liu C
Year: 2018
Journal: Cell
Title: Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites.
Volume: 172
Issue: 4
Pages: 706-718.e15
Publication
First Author: Tan C
Year: 2022
Journal: Neuron
Title: Rebuilding essential active zone functions within a synapse.
Volume: 110
Issue: 9
Pages: 1498-1515.e8
Publication    
First Author: Tan C
Year: 2022
Journal: Elife
Title: Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones.
Volume: 11
Publication
First Author: Fischer M
Year: 2009
Journal: Mol Cell Neurosci
Title: P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons.
Volume: 42
Issue: 2
Pages: 134-41
Publication
First Author: Cao Y
Year: 2022
Journal: Curr Biol
Title: Post-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviors.
Volume: 32
Issue: 22
Pages: 4783-4796.e3
Publication
First Author: Albrecht NE
Year: 2018
Journal: Cell Rep
Title: Rapid and Integrative Discovery of Retina Regulatory Molecules.
Volume: 24
Issue: 9
Pages: 2506-2519
Publication
First Author: Chen J
Year: 2011
Journal: J Neurosci
Title: Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones.
Volume: 31
Issue: 2
Pages: 512-25
Publication
First Author: Wentzel C
Year: 2013
Journal: Neuron
Title: mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking.
Volume: 78
Issue: 6
Pages: 1012-23
Publication
First Author: Schoch S
Year: 2006
Journal: EMBO J
Title: Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.
Volume: 25
Issue: 24
Pages: 5852-63
Publication
First Author: Jiang D
Year: 2020
Journal: J Comp Neurol
Title: Spatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae.
Volume: 528
Issue: 5
Pages: 729-755
Publication
First Author: Nakano Y
Year: 2019
Journal: Cell Rep
Title: Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.
Volume: 27
Issue: 3
Pages: 860-871.e8
Publication
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 1
Pages: 35-48
Publication      
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Regulatory Region
Type: enhancer
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 720  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 992  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 948  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 285  
Fragment?: true
Publication
First Author: Wang Y
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones.
Volume: 99
Issue: 22
Pages: 14464-9
Publication
First Author: Wagh DA
Year: 2006
Journal: Neuron
Title: Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in Drosophila.
Volume: 49
Issue: 6
Pages: 833-44
Protein Domain
Type: Family
Description: The active zone is the presynaptic region in the nerve terminals that mediates neurotransmitter release and is composed a dense collection of proteins called the cytomatrix at the active zone (CAZ). The CAZ proteins are thought to mediate synapse formation and regulate neurotransmitter release [, ].This entry represents the ELKS family, which are thought to be involved in the organisation of CAZ. Vertebrate ELKS proteins are produced by two genes, ERC1 and ERC2. Caenorhabditis elegans expresses a homologue of ELKS that acts downstream of syd2/liprin-alpha during active zone assembly []. Drosophila melanogaster expresses a related protein termed bruchpilot (brp) that consists of a conserved N terminus and a C-terminal half with no homologous sequences in vertebrates. Brp is required for structural integrity and function of synaptic active zones []. Vertebrate ELKS proteins are enriched at presynaptic active zones []and support Ca2+ influx at nerve terminals of inhibitory hippocampal neurons []. They have a C-terminal PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). These proteins also contain four coiled-coil domains [].
Protein
Organism: Mus musculus/domesticus
Length: 957  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 977  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 969  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 405  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 960  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 270  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 957  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 251  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 347  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 953  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1120  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1116  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1088  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1120  
Fragment?: false
Publication
First Author: Dai Y
Year: 2006
Journal: Nat Neurosci
Title: SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS.
Volume: 9
Issue: 12
Pages: 1479-87
Protein Domain
Type: Domain
Description: The Rab11 GTPase regulates recycling of internalized plasma membrane receptors and is essential for completion of cytokinesis. A family of Rab11 interacting proteins (FIPs) that conserve a C-terminal Rab-binding domain (RBD) selectively recognise the active form of Rab11. FIPs are diverse in sequence length and composition toward their N-termini, presumably a feature that underpins their specific roles in Rab11-mediated vesicle trafficking. They have been divided into three subfamilies (classe I, II, and III)on the basis of domain architecture. Class I FIPs comprises a subfamily of three proteins (Rip11/pp75/FIP5, Rab-coupling protein (RCP), and FIP2) that possess an N-terminal C2 domain, localize to recycling endosomes, and regulate plasma membrane recycling. The class II subfamily consists of two proteins (FIP3/eferin/arfophilin and FIP4) with tandem EF hands and a proline-rich region. Class II FIPs localize to recycling endosomes, the trans-Golgi network, and have been implicated in the regulation of membrane trafficking during cytokinesis. The class III subfamily consists of a single protein, FIP1, which does not contain obvious homology domains or motifs other than the FIP-RBD [, , , ].The FIP-RBD domain is also found in Rab6-interacting protein Erc1/Elks. Erc1 is the regulatory subunit of the IKK complex and probably recruits IkappaBalpha/NFKBIA to the complex []. It may be involved in the organisation of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. It may also be involved in vesicle trafficking at the CAZ, as well as in Rab-6 regulated endosomes to Golgi transport [].The FIB-RBD domain consists of an N-terminal long α-helix, followed by a 90 degrees bend at a conserved proline residue, a 3(10) helix and a C-terminal short β-strand, adopting an "L"shape. The long α-helix forms a parallel coiled-coil homodimer that symmetrically interacts with two Rab11 molecules on both sides, forming a quaternary Rab11-(FIP)2-Rab11 complex. The Rab11-interacting region of FIP-RBD is confined to the C-terminal 24 amino acids, which cover the C-terminal half of the long α-helix and the short β-strand [, , , ]. This entry represents the FIP-RBD C-terminal domain.
Protein Domain
Type: Homologous_superfamily
Description: The Rab11 GTPase regulates recycling of internalized plasma membrane receptors and is essential for completion of cytokinesis. A family of Rab11 interacting proteins (FIPs) that conserve a C-terminal Rab-binding domain (RBD) selectively recognise the active form of Rab11. FIPs are diverse in sequence length and composition toward their N-termini, presumably a feature that underpins their specific roles in Rab11-mediated vesicle trafficking. They have been divided into three subfamilies (classe I, II, and III)on the basis of domain architecture. Class I FIPs comprises a subfamily of three proteins (Rip11/pp75/FIP5, Rab-coupling protein (RCP), and FIP2) that possess an N-terminal C2 domain, localize to recycling endosomes, and regulate plasma membrane recycling. The class II subfamily consists of two proteins (FIP3/eferin/arfophilin and FIP4) with tandem EF hands and a proline-rich region. Class II FIPs localize to recycling endosomes, the trans-Golgi network, and have been implicated in the regulation of membrane trafficking during cytokinesis. The class III subfamily consists of a single protein, FIP1, which does not contain obvious homology domains or motifs other than the FIP-RBD [, , , ].The FIP-RBD domain is also found in Rab6-interacting protein Erc1/Elks. Erc1 is the regulatory subunit of the IKK complex and probably recruits IkappaBalpha/NFKBIA to the complex []. It may be involved in the organisation of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. It may also be involved in vesicle trafficking at the CAZ, as well as in Rab-6 regulated endosomes to Golgi transport [].The FIB-RBD domain consists of an N-terminal long α-helix, followed by a 90 degrees bend at a conserved proline residue, a 3(10) helix and a C-terminal short β-strand, adopting an "L"shape. The long α-helix forms a parallel coiled-coil homodimer that symmetrically interacts with two Rab11 molecules on both sides, forming a quaternary Rab11-(FIP)2-Rab11 complex. The Rab11-interacting region of FIP-RBD is confined to the C-terminal 24 amino acids, which cover the C-terminal half of the long α-helix and the short β-strand [, , , ]. This entry represents the FIP-RBD C-terminal domain.
Protein
Organism: Mus musculus/domesticus
Length: 1047  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 635  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 518  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 163  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 370  
Fragment?: false
Publication
First Author: Jagoe WN
Year: 2006
Journal: Structure
Title: Crystal structure of rab11 in complex with rab11 family interacting protein 2.
Volume: 14
Issue: 8
Pages: 1273-83
Publication
First Author: Eathiraj S
Year: 2006
Journal: J Mol Biol
Title: Structural basis for Rab11-mediated recruitment of FIP3 to recycling endosomes.
Volume: 364
Issue: 2
Pages: 121-35
Publication
First Author: Shiba T
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1.
Volume: 103
Issue: 42
Pages: 15416-21
Publication
First Author: Wei J
Year: 2009
Journal: Biochemistry
Title: Disorder and structure in the Rab11 binding domain of Rab11 family interacting protein 2.
Volume: 48
Issue: 3
Pages: 549-57
Publication
First Author: Ducut Sigala JL
Year: 2004
Journal: Science
Title: Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit.
Volume: 304
Issue: 5679
Pages: 1963-7
Protein
Organism: Mus musculus/domesticus
Length: 645  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 645  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 512  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1318  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 529  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1166  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1353  
Fragment?: true
Publication
First Author: tom Dieck S
Year: 2012
Journal: J Neurosci
Title: Deletion of the presynaptic scaffold CAST reduces active zone size in rod photoreceptors and impairs visual processing.
Volume: 32
Issue: 35
Pages: 12192-203
Publication  
First Author: Lazarevic V
Year: 2013
Journal: Front Cell Neurosci
Title: Molecular mechanisms driving homeostatic plasticity of neurotransmitter release.
Volume: 7
Pages: 244