DIS3-like exonuclease 2 (DIS3L2) is a 3'-5'-exoribonuclease that specifically recognises RNAs polyuridylated at their 3' end and mediates their degradation. It plays an important role in the mRNA degradation pathway alternative to degradation by Xrn1 and the exosome [, ]. This entry also includes DIS3L2 plant homologue, SUPPRESSOR OF VARICOSE (SOV) (At1g77680), which functions in cytoplasmic mRNA decay and suppresses Arabidopsis decapping mutant phenotypes [].
This is the C-terminal S1 domain found in Dis3L2 proteins. Dis3L2 belongs to the RNase II/R 3-5 exonuclease superfamily, which includes the catalytic subunit of the RNA exosome in yeast and in humans [].
