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Search results 301 to 335 out of 335 for Malt1

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Type Details Score
Publication
17468049 | -
First Author: Thome M
Year: 2007
Journal: Trends Immunol
Title: Post-translational modifications regulate distinct functions of CARMA1 and BCL10.
Volume: 28
Issue: 6
Pages: 281-8
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Publication
30022982 | -
 
First Author: Gehring T
Year: 2018
Journal: Front Immunol
Title: BCL10 - Bridging CARDs to Immune Activation.
Volume: 9
Pages: 1539
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Protein Domain
IPR042143 | CARD_BCL10
Type: Domain
Description: This entry represents the CARD domain found in B-cell lymphoma/leukemia 10 (BCL10). BCL10 and Malt1 (mucosa-associated lymphoid tissue-lymphoma-translocation gene 1) are the integral components of CBM signalosomes. They associate with CARD9 to form M-CBM (CBM complex in myeloid immune cells) and with CARMA1 to form L-CBM (CBM complex in lymphoid immune cells), to mediate activation of NF-kB and MAPK by ITAM-coupled receptors expressed on immune cells. Both CARMA1 and CARD9 associate with BCL10 via a CARD-CARD interaction [, ].In general, CARDs are death domains (DDs) found associated with caspases []. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms []. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes [].
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Protein Domain
IPR042142 | CARD_CARD9
Type: Domain
Description: This entry represents the CARD domain found in CARD9, which is a central regulator of innate immunity and is highly expressed in dendritic cells and macrophages []. Together with BCL10 (B-cell lymphoma 10) and Malt1 (mucosa-associated lymphoid tissue-lymphoma-translocation gene 1), it forms the M-CBM signalosome (the CBM complex in myeloid immune cells), which mediates activation of NF-kB and MAPK by ITAM-coupled receptors expressed on immune cells. CARD9 associates with BCL10 via a CARD-CARD interaction [].In general, CARDs are death domains (DDs) found associated with caspases []. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms []. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes [].
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Protein Domain
IPR042141 | CARD_CARD11
Type: Domain
Description: This entry represents the CARD domain found in CARD11, also known as CARMA1. CARMA1, together with BCL10 (B-cell lymphoma 10) and Malt1 (mucosa-associated lymphoid tissue-lymphoma-translocation gene 1), form the L-CBM signalosome (CBM complex in lymphoid immune cells) which mediates activation of NF-kB and MAPK by ITAM-coupled receptors expressed on immune cells. CARMA1 associates with BCL10 via a CARD-CARD interaction [].In general, CARDs are death domains (DDs) found associated with caspases []. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms []. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes [].
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Protein Domain
IPR033238 | BCL10/E10
Type: Family
Description: This entry includes animal B-cell lymphoma/leukemia 10 (BCL10) and Equine herpesvirus protein E10.In lymphoid cells BCL10 plays a critical role in the activation of the transcription factor nuclear factor kappa B (NF-kB) downstream of a variety of immune receptors, including the TCR, B cell receptor, NK-cell receptors, C type family lectin receptors, Ig family receptors and G protein-coupled receptors [, , ]. Activation of NF-kB through receptor-mediated pathways requires BCL10 to form a complex (known as CBM) with the paracaspase MALT1 and with CARD-containing adaptor protein CARMA []. BCL10 is involved in the regulation of apoptosis; a BCL10 gene tanslocation is found in mucosa-associated lymphoid tissue (MALT) lymphomas [, ]. BCL10 is involved in the adaptive and innate immune response [, ]. Equine herpesvirus protein E10 (v-E10) is the viral homologue of the BCL10 protein []. It induces membrane recruitment of cellular BCL10, and this induces TRAF-mediated NF-kappaB activation [].
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Publication
32150623 | J:289862
 
First Author: Rome KS
Year: 2020
Journal: J Exp Med
Title: Trib1 regulates T cell differentiation during chronic infection by restraining the effector program.
Volume: 217
Issue: 5
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Publication
22708078 | J:196026
First Author: Van Beek M
Year: 2012
Journal: Cell Rep
Title: Bcl10 links saturated fat overnutrition with hepatocellular NF-kB activation and insulin resistance.
Volume: 1
Issue: 5
Pages: 444-52
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Publication
35831018 | J:344986
First Author: Cheng L
Year: 2022
Journal: J Immunol
Title: Carma3 Protects from Liver Injury by Preserving Mitochondrial Integrity in Liver Sinusoidal Endothelial Cells.
Volume: 209
Issue: 3
Pages: 456-464
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Publication
15122758 | J:105553
First Author: Jadhao SB
Year: 2004
Journal: Hepatology
Title: Murine alanine aminotransferase: cDNA cloning, functional expression, and differential gene regulation in mouse fatty liver.
Volume: 39
Issue: 5
Pages: 1297-302
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Publication
33640899 | J:340065
First Author: Yu Z
Year: 2021
Journal: Signal Transduct Target Ther
Title: TRIM41 is required to innate antiviral response by polyubiquitinating BCL10 and recruiting NEMO.
Volume: 6
Issue: 1
Pages: 90
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Publication
26400962 | J:230074
First Author: Hathcock KS
Year: 2015
Journal: Blood
Title: ATM deficiency promotes development of murine B-cell lymphomas that resemble diffuse large B-cell lymphoma in humans.
Volume: 126
Issue: 20
Pages: 2291-301
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Publication
35296093 | J:321958
 
First Author: Goral A
Year: 2022
Journal: Front Immunol
Title: A Specific CD44lo CD25lo Subpopulation of Regulatory T Cells Inhibits Anti-Leukemic Immune Response and Promotes the Progression in a Mouse Model of Chronic Lymphocytic Leukemia.
Volume: 13
Pages: 781364
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Publication
18081036 | J:130528
First Author: Hinshaw-Makepeace J
Year: 2008
Journal: Eur J Immunol
Title: c-FLIP(S) reduces activation of caspase and NF-kappaB pathways and decreases T cell survival.
Volume: 38
Issue: 1
Pages: 54-63
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Publication
21048983 | J:166899
First Author: Conze DB
Year: 2010
Journal: PLoS Biol
Title: Non-canonical NF-κB activation and abnormal B cell accumulation in mice expressing ubiquitin protein ligase-inactive c-IAP2.
Volume: 8
Issue: 10
Pages: e1000518
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Publication
29263935 | J:255787
 
First Author: Li Y
Year: 2017
Journal: Signal Transduct Target Ther
Title: Central role of myeloid MCPIP1 in protecting against LPS-induced inflammation and lung injury.
Volume: 2
Pages: 17066
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Publication
21771792 | J:176611
First Author: Rajasekaran K
Year: 2011
Journal: J Biol Chem
Title: Transforming growth factor-beta-activated kinase 1 regulates natural killer cell-mediated cytotoxicity and cytokine production.
Volume: 286
Issue: 36
Pages: 31213-24
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Publication
34406363 | J:323008
 
First Author: Pieters T
Year: 2021
Journal: J Exp Med
Title: Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice.
Volume: 218
Issue: 10
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Publication
32763502 | J:307276
 
First Author: Rios KE
Year: 2020
Journal: Cell Immunol
Title: CARD19, the protein formerly known as BinCARD, is a mitochondrial protein that does not regulate Bcl10-dependent NF-κB activation after TCR engagement.
Volume: 356
Pages: 104179
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Publication
16707452 | J:109055
First Author: Baens M
Year: 2006
Journal: Cancer Res
Title: Selective expansion of marginal zone B cells in Emicro-API2-MALT1 mice is linked to enhanced IkappaB kinase gamma polyubiquitination.
Volume: 66
Issue: 10
Pages: 5270-7
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Publication
19118383 | J:146202
First Author: Bidère N
Year: 2009
Journal: Nature
Title: Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival.
Volume: 458
Issue: 7234
Pages: 92-6
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Publication
23335970 | J:195859
First Author: Thuille N
Year: 2013
Journal: PLoS One
Title: PKCθ/β and CYLD are antagonistic partners in the NFκB and NFAT transactivation pathways in primary mouse CD3+ T lymphocytes.
Volume: 8
Issue: 1
Pages: e53709
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Publication
32970964 | J:323392
First Author: Percier P
Year: 2021
Journal: Am J Respir Cell Mol Biol
Title: Aspergillus fumigatus Recognition by Dendritic Cells Negatively Regulates Allergic Lung Inflammation through a TLR2/MyD88 Pathway.
Volume: 64
Issue: 1
Pages: 39-49
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Protein
Q9Z0H7
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: false
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Protein
Q3THY9
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: false
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Protein
B7ZWE5
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: false
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Protein Coding Gene
MGI:1916978 | Card11
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q3U487
Organism: Mus musculus/domesticus
Length: 861  
Fragment?: false
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Protein
A2AIV8
Organism: Mus musculus/domesticus
Length: 536  
Fragment?: false
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Protein Coding Gene
MGI:2685628 | Card9
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
9175472 | -
First Author: Hofmann K
Year: 1997
Journal: Trends Biochem Sci
Title: The CARD domain: a new apoptotic signalling motif.
Volume: 22
Issue: 5
Pages: 155-6
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Publication
12101092 | -
First Author: Bouchier-Hayes L
Year: 2002
Journal: EMBO Rep
Title: CARD games in apoptosis and immunity.
Volume: 3
Issue: 7
Pages: 616-21
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Protein
Q8CIS0
Organism: Mus musculus/domesticus
Length: 1159  
Fragment?: false
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Publication
17201679 | -
 
First Author: Park HH
Year: 2007
Journal: Annu Rev Immunol
Title: The death domain superfamily in intracellular signaling of apoptosis and inflammation.
Volume: 25
Pages: 561-86
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Protein Coding Gene
MGI:1337994 | Bcl10
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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