Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
lemur, mouse |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cat, domestic |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Ikeda T |
Year: |
1991 |
Journal: |
J Bone Miner Res |
Title: |
cDNA and deduced amino acid sequence of mouse matrix gla protein: one of five glutamic acid residues potentially modified to gla is not conserved in the mouse sequence. |
Volume: |
6 |
Issue: |
9 |
Pages: |
1013-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sharma B |
Year: |
2013 |
Journal: |
Microvasc Res |
Title: |
Matrix Gla protein reinforces angiogenic resolution. |
Volume: |
85 |
|
Pages: |
24-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Luo G |
Year: |
1995 |
Journal: |
J Bone Miner Res |
Title: |
The matrix Gla protein gene is a marker of the chondrogenesis cell lineage during mouse development. |
Volume: |
10 |
Issue: |
2 |
Pages: |
325-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Luo G |
Year: |
1997 |
Journal: |
Nature |
Title: |
Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. |
Volume: |
386 |
Issue: |
6620 |
Pages: |
78-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yao J |
Year: |
2016 |
Journal: |
Angiogenesis |
Title: |
Matrix Gla protein regulates differentiation of endothelial cells derived from mouse embryonic stem cells. |
Volume: |
19 |
Issue: |
1 |
Pages: |
1-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
El-Maadawy S |
Year: |
2003 |
Journal: |
Connect Tissue Res |
Title: |
Cartilage formation and calcification in arteries of mice lacking matrix Gla protein. |
Volume: |
44 Suppl 1 |
|
Pages: |
272-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaartinen MT |
Year: |
2007 |
Journal: |
J Histochem Cytochem |
Title: |
Osteopontin upregulation and polymerization by transglutaminase 2 in calcified arteries of Matrix Gla protein-deficient mice. |
Volume: |
55 |
Issue: |
4 |
Pages: |
375-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Malhotra R |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
Inhibition of bone morphogenetic protein signal transduction prevents the medial vascular calcification associated with matrix Gla protein deficiency. |
Volume: |
10 |
Issue: |
1 |
Pages: |
e0117098 |
|
•
•
•
•
•
|
Publication |
First Author: |
Borrás T |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
Generation of a Matrix Gla (Mgp) floxed mouse, followed by conditional knockout, uncovers a new Mgp function in the eye. |
Volume: |
10 |
Issue: |
1 |
Pages: |
18583 |
|
•
•
•
•
•
|
Publication |
First Author: |
Malhotra R |
Year: |
2022 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Matrix Gla Protein Levels Are Associated With Arterial Stiffness and Incident Heart Failure With Preserved Ejection Fraction. |
Volume: |
42 |
Issue: |
2 |
Pages: |
e61-e73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bangari DS |
Year: |
2015 |
Journal: |
Am J Pathol |
Title: |
α-Galactosidase A knockout mice: progressive organ pathology resembles the type 2 later-onset phenotype of Fabry disease. |
Volume: |
185 |
Issue: |
3 |
Pages: |
651-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lanham SA |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
The influence of a high fat diet on bone and soft tissue formation in Matrix Gla Protein knockout mice. |
Volume: |
8 |
Issue: |
1 |
Pages: |
3635 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang L |
Year: |
2024 |
Journal: |
Mol Metab |
Title: |
Two-step regulation by matrix Gla protein in brown adipose cell differentiation. |
Volume: |
80 |
|
Pages: |
101870 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Ioannou YA |
Year: |
2001 |
Journal: |
Am J Hum Genet |
Title: |
Fabry disease: preclinical studies demonstrate the effectiveness of alpha-galactosidase A replacement in enzyme-deficient mice. |
Volume: |
68 |
Issue: |
1 |
Pages: |
14-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Khanna R |
Year: |
2010 |
Journal: |
Mol Ther |
Title: |
The pharmacological chaperone 1-deoxygalactonojirimycin reduces tissue globotriaosylceramide levels in a mouse model of Fabry disease. |
Volume: |
18 |
Issue: |
1 |
Pages: |
23-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Parashar A |
Year: |
2022 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Prevention of Arterial Elastocalcinosis: Differential Roles of the Conserved Glutamic Acid and Serine Residues of Matrix Gla Protein. |
Volume: |
42 |
Issue: |
6 |
Pages: |
e155-e167 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yao Y |
Year: |
2011 |
Journal: |
J Clin Invest |
Title: |
Matrix Gla protein deficiency causes arteriovenous malformations in mice. |
Volume: |
121 |
Issue: |
8 |
Pages: |
2993-3004 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
104
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
104
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
93
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
104
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Yao Y |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Reducing Jagged 1 and 2 levels prevents cerebral arteriovenous malformations in matrix Gla protein deficiency. |
Volume: |
110 |
Issue: |
47 |
Pages: |
19071-6 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
226
|
Fragment?: |
false |
|
•
•
•
•
•
|
Author |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2019 |
Journal: |
Mol Cell Biol |
Title: |
Unexpected Role of Matrix Gla Protein in Osteoclasts: Inhibiting Osteoclast Differentiation and Bone Resorption. |
Volume: |
39 |
Issue: |
12 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hui ST |
Year: |
2023 |
Journal: |
Cell Mol Gastroenterol Hepatol |
Title: |
Role of Matrix Gla Protein in Transforming Growth Factor-β Signaling and Nonalcoholic Steatohepatitis in Mice. |
Volume: |
16 |
Issue: |
6 |
Pages: |
943-960 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marshall J |
Year: |
2010 |
Journal: |
PLoS One |
Title: |
Substrate reduction augments the efficacy of enzyme therapy in a mouse model of Fabry disease. |
Volume: |
5 |
Issue: |
11 |
Pages: |
e15033 |
|
•
•
•
•
•
|
Publication |
First Author: |
Speer MY |
Year: |
2002 |
Journal: |
J Exp Med |
Title: |
Inactivation of the osteopontin gene enhances vascular calcification of matrix Gla protein-deficient mice: evidence for osteopontin as an inducible inhibitor of vascular calcification in vivo. |
Volume: |
196 |
Issue: |
8 |
Pages: |
1047-55 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
218
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
38
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen FW |
Year: |
2022 |
Journal: |
iScience |
Title: |
Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunction. |
Volume: |
25 |
Issue: |
9 |
Pages: |
104941 |
|
•
•
•
•
•
|
Publication |
First Author: |
Johnson TL |
Year: |
1991 |
Journal: |
Genomics |
Title: |
Chromosomal assignment in mouse of matrix Gla protein and bone Gla protein genes. |
Volume: |
11 |
Issue: |
3 |
Pages: |
770-2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Conceição N |
Year: |
2002 |
Journal: |
Eur J Biochem |
Title: |
Molecular cloning of the Matrix Gla Protein gene from Xenopus laevis. Functional analysis of the promoter identifies a calcium sensitive region required for basal activity. |
Volume: |
269 |
Issue: |
7 |
Pages: |
1947-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Young J |
Year: |
2011 |
Journal: |
J Am Chem Soc |
Title: |
Matrix Gla protein inhibits ectopic calcification by a direct interaction with hydroxyapatite crystals. |
Volume: |
133 |
Issue: |
45 |
Pages: |
18406-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Munroe PB |
Year: |
1999 |
Journal: |
Nat Genet |
Title: |
Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome. |
Volume: |
21 |
Issue: |
1 |
Pages: |
142-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shen Y |
Year: |
2006 |
Journal: |
Stroke |
Title: |
Alpha-galactosidase A deficiency leads to increased tissue fibrin deposition and thrombosis in mice homozygous for the factor V Leiden mutation. |
Volume: |
37 |
Issue: |
4 |
Pages: |
1106-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park JL |
Year: |
2009 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
Differential involvement of COX1 and COX2 in the vasculopathy associated with the alpha-galactosidase A-knockout mouse. |
Volume: |
296 |
Issue: |
4 |
Pages: |
H1133-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Togawa T |
Year: |
2010 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Tissue and plasma globotriaosylsphingosine could be a biomarker for assessing enzyme replacement therapy for Fabry disease. |
Volume: |
399 |
Issue: |
4 |
Pages: |
716-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Eitzman DT |
Year: |
2003 |
Journal: |
J Am Soc Nephrol |
Title: |
Fabry disease in mice is associated with age-dependent susceptibility to vascular thrombosis. |
Volume: |
14 |
Issue: |
2 |
Pages: |
298-302 |
|
•
•
•
•
•
|
Publication |
First Author: |
Noben-Trauth K |
Year: |
2007 |
Journal: |
Hear Res |
Title: |
Normal hearing in alpha-galactosidase A-deficient mice, the mouse model for Fabry disease. |
Volume: |
234 |
Issue: |
1-2 |
Pages: |
10-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bodary PF |
Year: |
2005 |
Journal: |
Circulation |
Title: |
Alpha-galactosidase A deficiency accelerates atherosclerosis in mice with apolipoprotein E deficiency. |
Volume: |
111 |
Issue: |
5 |
Pages: |
629-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kang JJ |
Year: |
2019 |
Journal: |
PLoS One |
Title: |
Voluntary wheel running activates Akt/AMPK/eNOS signaling cascades without improving profound endothelial dysfunction in mice deficient in α-galactosidase A. |
Volume: |
14 |
Issue: |
5 |
Pages: |
e0217214 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tajima Y |
Year: |
2009 |
Journal: |
Am J Hum Genet |
Title: |
Use of a modified alpha-N-acetylgalactosaminidase in the development of enzyme replacement therapy for Fabry disease. |
Volume: |
85 |
Issue: |
5 |
Pages: |
569-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Klug K |
Year: |
2023 |
Journal: |
Int J Mol Sci |
Title: |
Endothelial Cell Dysfunction and Hypoxia as Potential Mediators of Pain in Fabry Disease: A Human-Murine Translational Approach. |
Volume: |
24 |
Issue: |
20 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Park S |
Year: |
2011 |
Journal: |
Cardiovasc Res |
Title: |
Globotriaosylceramide leads to K(Ca)3.1 channel dysfunction: a new insight into endothelial dysfunction in Fabry disease. |
Volume: |
89 |
Issue: |
2 |
Pages: |
290-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kugadas A |
Year: |
2024 |
Journal: |
PLoS One |
Title: |
Cardiac manifestations of Fabry disease in G3Stg/GlaKO and GlaKO mouse models-Translation to Fabry disease patients. |
Volume: |
19 |
Issue: |
5 |
Pages: |
e0304415 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boström KI |
Year: |
2015 |
Journal: |
Eur Respir J |
Title: |
Matrix Gla protein limits pulmonary arteriovenous malformations in ALK1 deficiency. |
Volume: |
45 |
Issue: |
3 |
Pages: |
849-52 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohshima T |
Year: |
1995 |
Journal: |
Gene |
Title: |
Structural organization and expression of the mouse gene encoding alpha-galactosidase A. |
Volume: |
166 |
Issue: |
2 |
Pages: |
277-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gotlib RW |
Year: |
1996 |
Journal: |
Biochem Mol Med |
Title: |
The entire genomic sequence and cDNA expression of mouse alpha-galactosidase A. |
Volume: |
57 |
Issue: |
2 |
Pages: |
139-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohashi T |
Year: |
2008 |
Journal: |
Mol Genet Metab |
Title: |
Reduced alpha-Gal A enzyme activity in Fabry fibroblast cells and Fabry mice tissues induced by serum from antibody positive patients with Fabry disease. |
Volume: |
94 |
Issue: |
3 |
Pages: |
313-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rodrigues LG |
Year: |
2009 |
Journal: |
Neurobiol Dis |
Title: |
Neurophysiological, behavioral and morphological abnormalities in the Fabry knockout mice. |
Volume: |
33 |
Issue: |
1 |
Pages: |
48-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ishii S |
Year: |
2004 |
Journal: |
Biochim Biophys Acta |
Title: |
Transgenic mouse expressing human mutant alpha-galactosidase A in an endogenous enzyme deficient background: a biochemical animal model for studying active-site specific chaperone therapy for Fabry disease. |
Volume: |
1690 |
Issue: |
3 |
Pages: |
250-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lakomá J |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Pain related channels are differentially expressed in neuronal and non-neuronal cells of glabrous skin of fabry knockout male mice. |
Volume: |
9 |
Issue: |
10 |
Pages: |
e108641 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shu L |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
Caveolin-associated accumulation of globotriaosylceramide in the vascular endothelium of alpha-galactosidase A null mice. |
Volume: |
282 |
Issue: |
29 |
Pages: |
20960-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aerts JM |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Elevated globotriaosylsphingosine is a hallmark of Fabry disease. |
Volume: |
105 |
Issue: |
8 |
Pages: |
2812-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Taguchi A |
Year: |
2013 |
Journal: |
Biochem J |
Title: |
A symptomatic Fabry disease mouse model generated by inducing globotriaosylceramide synthesis. |
Volume: |
456 |
Issue: |
3 |
Pages: |
373-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shu L |
Year: |
2009 |
Journal: |
J Am Soc Nephrol |
Title: |
Decreased nitric oxide bioavailability in a mouse model of Fabry disease. |
Volume: |
20 |
Issue: |
9 |
Pages: |
1975-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shen JS |
Year: |
2017 |
Journal: |
Hum Mol Genet |
Title: |
Tetrahydrobiopterin deficiency in the pathogenesis of Fabry disease. |
Volume: |
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