Type |
Details |
Score |
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1881228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691526 |
Age: |
postnatal adult |
Image: |
HMGU_692935 |
|
Specimen Label: |
HMGU_692935 |
Detected: |
true |
Specimen Num: |
19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muranski P |
Year: |
2011 |
Journal: |
Immunity |
Title: |
Th17 cells are long lived and retain a stem cell-like molecular signature. |
Volume: |
35 |
Issue: |
6 |
Pages: |
972-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shin HM |
Year: |
2013 |
Journal: |
Immunity |
Title: |
Epigenetic modifications induced by Blimp-1 Regulate CD8⁺ T cell memory progression during acute virus infection. |
Volume: |
39 |
Issue: |
4 |
Pages: |
661-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Taghon T |
Year: |
2006 |
Journal: |
Immunity |
Title: |
Developmental and molecular characterization of emerging beta- and gammadelta-selected pre-T cells in the adult mouse thymus. |
Volume: |
24 |
Issue: |
1 |
Pages: |
53-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schmolka N |
Year: |
2018 |
Journal: |
Sci Immunol |
Title: |
MicroRNA-146a controls functional plasticity in γδ T cells by targeting NOD1. |
Volume: |
3 |
Issue: |
23 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Klein F |
Year: |
2019 |
Journal: |
J Exp Med |
Title: |
The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection. |
Volume: |
216 |
Issue: |
3 |
Pages: |
638-655 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ballesteros-Tato A |
Year: |
2014 |
Journal: |
Immunity |
Title: |
Epitope-specific regulation of memory programming by differential duration of antigen presentation to influenza-specific CD8(+) T cells. |
Volume: |
41 |
Issue: |
1 |
Pages: |
127-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
García P |
Year: |
2004 |
Journal: |
J Leukoc Biol |
Title: |
Signalling via CD70, a member of the TNF family, regulates T cell functions. |
Volume: |
76 |
Issue: |
1 |
Pages: |
263-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Johansson SE |
Year: |
2011 |
Journal: |
Cell Immunol |
Title: |
Accumulation and activation of natural killer cells in local intraperitoneal HIV-1/MuLV infection results in early control of virus infected cells. |
Volume: |
272 |
Issue: |
1 |
Pages: |
71-8 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain -a region that contains many cysteine residues arranged in a specific repetitive pattern []. The cysteines allow formation of an extended rod-like structure, responsible for ligand binding []. Upon receptor activation, different intracellular signalling complexes are assembled for different members of the TNFR superfamily, depending on their intracellular domains and sequences []. Activation of TNFRs can therefore induce a range of disparate effects, including cell proliferation, differentiation, survival, or apoptotic cell death, depending upon the receptor involved [, ]. TNFRs are widely distributed and play important roles in many crucial biological processes, such as lymphoid and neuronal development, innate and adaptive immunity, and maintenance of cellular homeostasis []. Drugs that manipulate their signalling have potential roles in the prevention and treatment of many diseases, such as viral infections, coronary heart disease, transplant rejection, and immune disease []. TNF receptor 7, otherwise known as CD27 antigen, is expressed on discrete subpopulations of T-and B-cells []. The receptor plays a vital role in the generation and long-term maintenance of T-cell immunity []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Tesselaar K |
Year: |
1997 |
Journal: |
J Immunol |
Title: |
Characterization of murine CD70, the ligand of the TNF receptor family member CD27. |
Volume: |
159 |
Issue: |
10 |
Pages: |
4959-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nocentini G |
Year: |
1997 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. |
Volume: |
94 |
Issue: |
12 |
Pages: |
6216-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Teng MS |
Year: |
2002 |
Journal: |
Eur J Immunol |
Title: |
A human TAPBP (TAPASIN)-related gene, TAPBP-R. |
Volume: |
32 |
Issue: |
4 |
Pages: |
1059-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Harms RZ |
Year: |
2017 |
Journal: |
Front Immunol |
Title: |
Interleukin (IL)-18 Binding Protein Deficiency Disrupts Natural Killer Cell Maturation and Diminishes Circulating IL-18. |
Volume: |
8 |
|
Pages: |
1020 |
|
•
•
•
•
•
|
Publication |
First Author: |
Munitic I |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to lymphocytic choriomeningitis virus. |
Volume: |
190 |
Issue: |
3 |
Pages: |
1169-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Beyranvand Nejad E |
Year: |
2016 |
Journal: |
Cancer Res |
Title: |
Tumor Eradication by Cisplatin Is Sustained by CD80/86-Mediated Costimulation of CD8+ T Cells. |
Volume: |
76 |
Issue: |
20 |
Pages: |
6017-6029 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dong H |
Year: |
2015 |
Journal: |
Eur J Immunol |
Title: |
CD70 and IFN-1 selectively induce eomesodermin or T-bet and synergize to promote CD8+ T-cell responses. |
Volume: |
45 |
Issue: |
12 |
Pages: |
3289-301 |
|
•
•
•
•
•
|
Publication |
First Author: |
van Olffen RW |
Year: |
2010 |
Journal: |
J Innate Immun |
Title: |
CD70-driven chronic immune activation is protective against atherosclerosis. |
Volume: |
2 |
Issue: |
4 |
Pages: |
344-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ballas ZK |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Role of NK cell subsets in organ-specific murine melanoma metastasis. |
Volume: |
8 |
Issue: |
6 |
Pages: |
e65599 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maillard I |
Year: |
2006 |
Journal: |
J Exp Med |
Title: |
The requirement for Notch signaling at the beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor. |
Volume: |
203 |
Issue: |
10 |
Pages: |
2239-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Y |
Year: |
2017 |
Journal: |
J Immunol |
Title: |
Involvement of NK Cells in IL-28B-Mediated Immunity against Influenza Virus Infection. |
Volume: |
199 |
Issue: |
3 |
Pages: |
1012-1020 |
|
•
•
•
•
•
|
Publication |
First Author: |
Demirci G |
Year: |
2004 |
Journal: |
J Immunol |
Title: |
Critical role of OX40 in CD28 and CD154-independent rejection. |
Volume: |
172 |
Issue: |
3 |
Pages: |
1691-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fuse S |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
Control of memory CD8+ T cell differentiation by CD80/CD86-CD28 costimulation and restoration by IL-2 during the recall response. |
Volume: |
180 |
Issue: |
2 |
Pages: |
1148-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kemball CC |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
Costimulation requirements for antiviral CD8+ T cells differ for acute and persistent phases of polyoma virus infection. |
Volume: |
176 |
Issue: |
3 |
Pages: |
1814-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fogel LA |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
Markers of nonselective and specific NK cell activation. |
Volume: |
190 |
Issue: |
12 |
Pages: |
6269-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Redmond WL |
Year: |
2007 |
Journal: |
J Immunol |
Title: |
Defects in the acquisition of CD8 T cell effector function after priming with tumor or soluble antigen can be overcome by the addition of an OX40 agonist. |
Volume: |
179 |
Issue: |
11 |
Pages: |
7244-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sandau MM |
Year: |
2010 |
Journal: |
J Immunol |
Title: |
IL-15 regulates both quantitative and qualitative features of the memory CD8 T cell pool. |
Volume: |
184 |
Issue: |
1 |
Pages: |
35-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ong S |
Year: |
2015 |
Journal: |
Am J Pathol |
Title: |
Natural killer cells limit cardiac inflammation and fibrosis by halting eosinophil infiltration. |
Volume: |
185 |
Issue: |
3 |
Pages: |
847-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Leigh ND |
Year: |
2017 |
Journal: |
J Immunol |
Title: |
Host-Derived CD70 Suppresses Murine Graft-versus-Host Disease by Limiting Donor T Cell Expansion and Effector Function. |
Volume: |
199 |
Issue: |
1 |
Pages: |
336-347 |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Neill RE |
Year: |
2017 |
Journal: |
J Immunol |
Title: |
T Cell-Derived CD70 Delivers an Immune Checkpoint Function in Inflammatory T Cell Responses. |
Volume: |
199 |
Issue: |
10 |
Pages: |
3700-3710 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mikkelsen M |
Year: |
2011 |
Journal: |
J Immunol |
Title: |
Enhanced and sustained CD8+ T cell responses with an adenoviral vector-based hepatitis C virus vaccine encoding NS3 linked to the MHC class II chaperone protein invariant chain. |
Volume: |
186 |
Issue: |
4 |
Pages: |
2355-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tangye SG |
Year: |
2002 |
Journal: |
Eur J Immunol |
Title: |
CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2. |
Volume: |
32 |
Issue: |
6 |
Pages: |
1640-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Patra AK |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
PKB rescues calcineurin/NFAT-induced arrest of Rag expression and pre-T cell differentiation. |
Volume: |
177 |
Issue: |
7 |
Pages: |
4567-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Despoix N |
Year: |
2008 |
Journal: |
Eur J Immunol |
Title: |
Mouse CD146/MCAM is a marker of natural killer cell maturation. |
Volume: |
38 |
Issue: |
10 |
Pages: |
2855-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawamura T |
Year: |
2011 |
Journal: |
J Invest Dermatol |
Title: |
CD70 is selectively expressed on Th1 but not on Th2 cells and is required for Th1-type immune responses. |
Volume: |
131 |
Issue: |
6 |
Pages: |
1252-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muschaweckh A |
Year: |
2017 |
Journal: |
J Immunol |
Title: |
IL-1β and IL-23 Promote Extrathymic Commitment of CD27+CD122- γδ T Cells to γδT17 Cells. |
Volume: |
199 |
Issue: |
8 |
Pages: |
2668-2679 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ye C |
Year: |
2020 |
Journal: |
J Immunol |
Title: |
CD70 Inversely Regulates Regulatory T Cells and Invariant NKT Cells and Modulates Type 1 Diabetes in NOD Mice. |
Volume: |
205 |
Issue: |
7 |
Pages: |
1763-1777 |
|
•
•
•
•
•
|
Publication |
First Author: |
Forbes CA |
Year: |
2016 |
Journal: |
J Immunol |
Title: |
Ly49C Impairs NK Cell Memory in Mouse Cytomegalovirus Infection. |
Volume: |
197 |
Issue: |
1 |
Pages: |
128-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Karmaus PWF |
Year: |
2019 |
Journal: |
Nature |
Title: |
Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity. |
Volume: |
565 |
Issue: |
7737 |
Pages: |
101-105 |
|
•
•
•
•
•
|
Publication |
First Author: |
Luo J |
Year: |
2013 |
Journal: |
Mol Immunol |
Title: |
Up-regulation of transcription factor Blimp1 in systemic lupus erythematosus. |
Volume: |
56 |
Issue: |
4 |
Pages: |
574-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cottle DL |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
SLIMMER (FHL1B/KyoT3) interacts with the proapoptotic protein Siva-1 (CD27BP) and delays skeletal myoblast apoptosis. |
Volume: |
284 |
Issue: |
39 |
Pages: |
26964-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park IK |
Year: |
2017 |
Journal: |
Leukemia |
Title: |
E3 ubiquitin ligase Cbl-b activates the p53 pathway by targeting Siva1, a negative regulator of ARF, in FLT3 inhibitor-resistant acute myeloid leukemia. |
Volume: |
31 |
Issue: |
2 |
Pages: |
502-505 |
|
•
•
•
•
•
|
Publication |
First Author: |
Van Nostrand JL |
Year: |
2015 |
Journal: |
Cancer Discov |
Title: |
The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development. |
Volume: |
5 |
Issue: |
6 |
Pages: |
622-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jacobs SBR |
Year: |
2020 |
Journal: |
Cell Death Differ |
Title: |
Siva plays a critical role in mouse embryonic development. |
Volume: |
27 |
Issue: |
1 |
Pages: |
297-309 |
|
•
•
•
•
•
|
Publication |
First Author: |
Du W |
Year: |
2009 |
Journal: |
Cell Death Differ |
Title: |
Suppression of p53 activity by Siva1. |
Volume: |
16 |
Issue: |
11 |
Pages: |
1493-504 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
195
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Jacobs SB |
Year: |
2007 |
Journal: |
Cell Death Differ |
Title: |
Siva is an apoptosis-selective p53 target gene important for neuronal cell death. |
Volume: |
14 |
Issue: |
7 |
Pages: |
1374-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
E S |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
Lysophosphatidic acid 2 receptor-mediated supramolecular complex formation regulates its antiapoptotic effect. |
Volume: |
284 |
Issue: |
21 |
Pages: |
14558-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Naismith JH |
Year: |
1998 |
Journal: |
Trends Biochem Sci |
Title: |
Modularity in the TNF-receptor family. |
Volume: |
23 |
Issue: |
2 |
Pages: |
74-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bodmer JL |
Year: |
2002 |
Journal: |
Trends Biochem Sci |
Title: |
The molecular architecture of the TNF superfamily. |
Volume: |
27 |
Issue: |
1 |
Pages: |
19-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Coccia E |
Year: |
2020 |
Journal: |
Cell Death Dis |
Title: |
SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L. |
Volume: |
11 |
Issue: |
2 |
Pages: |
82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Banner DW |
Year: |
1993 |
Journal: |
Cell |
Title: |
Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation. |
Volume: |
73 |
Issue: |
3 |
Pages: |
431-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gravestein LA |
Year: |
1998 |
Journal: |
Semin Immunol |
Title: |
Tumor necrosis factor receptor family members in the immune system. |
Volume: |
10 |
Issue: |
6 |
Pages: |
423-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Armitage RJ |
Year: |
1994 |
Journal: |
Curr Opin Immunol |
Title: |
Tumor necrosis factor receptor superfamily members and their ligands. |
Volume: |
6 |
Issue: |
3 |
Pages: |
407-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu H |
Year: |
2004 |
Journal: |
Adv Protein Chem |
Title: |
Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily. |
Volume: |
68 |
|
Pages: |
225-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sapir T |
Year: |
2022 |
Journal: |
Nat Commun |
Title: |
Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex. |
Volume: |
13 |
Issue: |
1 |
Pages: |
4209 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. |
Volume: |
10 |
Issue: |
10 |
Pages: |
1617-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
1999 |
Journal: |
Methods Enzymol |
Title: |
High-efficiency full-length cDNA cloning. |
Volume: |
303 |
|
Pages: |
19-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shibata K |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. |
Volume: |
10 |
Issue: |
11 |
Pages: |
1757-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katayama S |
Year: |
2005 |
Journal: |
Science |
Title: |
Antisense transcription in the mammalian transcriptome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1564-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sansom SN |
Year: |
2009 |
Journal: |
PLoS Genet |
Title: |
The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. |
Volume: |
5 |
Issue: |
6 |
Pages: |
e1000511 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dickinson ME |
Year: |
2016 |
Journal: |
Nature |
Title: |
High-throughput discovery of novel developmental phenotypes. |
Volume: |
537 |
Issue: |
7621 |
Pages: |
508-514 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2016 |
|
Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
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•
•
•
•
•
|
Publication |
First Author: |
Koscielny G |
Year: |
2014 |
Journal: |
Nucleic Acids Res |
Title: |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
Volume: |
42 |
Issue: |
Database issue |
Pages: |
D802-9 |
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Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
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Publication |
First Author: |
International Knockout Mouse Consortium |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
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Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2000 |
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Title: |
Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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