Type |
Details |
Score |
Publication |
First Author: |
Furuyashiki T |
Year: |
1999 |
Journal: |
J Neurosci |
Title: |
Citron, a Rho-target, interacts with PSD-95/SAP-90 at glutamatergic synapses in the thalamus. |
Volume: |
19 |
Issue: |
1 |
Pages: |
109-18 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gai M |
Year: |
2016 |
Journal: |
EMBO Rep |
Title: |
ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules. |
Volume: |
17 |
Issue: |
10 |
Pages: |
1396-1409 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cunto FD |
Year: |
2002 |
Journal: |
J Cell Sci |
Title: |
Essential role of citron kinase in cytokinesis of spermatogenic precursors. |
Volume: |
115 |
Issue: |
Pt 24 |
Pages: |
4819-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shiraishi Y |
Year: |
1999 |
Journal: |
J Neurosci |
Title: |
Cupidin, an isoform of Homer/Vesl, interacts with the actin cytoskeleton and activated rho family small GTPases and is expressed in developing mouse cerebellar granule cells. |
Volume: |
19 |
Issue: |
19 |
Pages: |
8389-400 |
|
•
•
•
•
•
|
Publication |
First Author: |
Little JN |
Year: |
2021 |
Journal: |
J Neurosci |
Title: |
Loss of Coiled-Coil Protein Cep55 Impairs Neural Stem Cell Abscission and Results in p53-Dependent Apoptosis in Developing Cortex. |
Volume: |
41 |
Issue: |
15 |
Pages: |
3344-3365 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schmahl J |
Year: |
2007 |
Journal: |
Nat Genet |
Title: |
PDGF signaling specificity is mediated through multiple immediate early genes. |
Volume: |
39 |
Issue: |
1 |
Pages: |
52-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baumgartner M |
Year: |
2018 |
Journal: |
Development |
Title: |
Minor spliceosome inactivation causes microcephaly, owing to cell cycle defects and death of self-amplifying radial glial cells. |
Volume: |
145 |
Issue: |
17 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Capecchi MR |
Year: |
2015 |
Journal: |
Nat Commun |
Title: |
ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination. |
Volume: |
6 |
|
Pages: |
8763 |
|
•
•
•
•
•
|
Publication |
First Author: |
Di Cunto F |
Year: |
2000 |
Journal: |
Neuron |
Title: |
Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis. |
Volume: |
28 |
Issue: |
1 |
Pages: |
115-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakano Y |
Year: |
2012 |
Journal: |
PLoS Genet |
Title: |
A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. |
Volume: |
8 |
Issue: |
10 |
Pages: |
e1002966 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the Europhenome Mouse Phenotyping Resource |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from Europhenome |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cobellis G |
Year: |
2005 |
Journal: |
Nucleic Acids Res |
Title: |
Tagging genes with cassette-exchange sites. |
Volume: |
33 |
Issue: |
4 |
Pages: |
e44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miller JA |
Year: |
2013 |
Journal: |
Development |
Title: |
Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. |
Volume: |
140 |
Issue: |
22 |
Pages: |
4633-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP) |
Year: |
2011 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ingham NJ |
Year: |
2019 |
Journal: |
PLoS Biol |
Title: |
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. |
Volume: |
17 |
Issue: |
4 |
Pages: |
e3000194 |
|
•
•
•
•
•
|
Publication |
First Author: |
GO Central curators, GOA curators, Rhea curators |
Year: |
2020 |
|
Title: |
Automatic Gene Ontology annotation based on Rhea mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2023 |
|
Title: |
TreeGrafter-generated GO annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Thompson CL |
Year: |
2014 |
Journal: |
Neuron |
Title: |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
Volume: |
83 |
Issue: |
2 |
Pages: |
309-323 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
|
Title: |
Rat to Mouse ISO GO annotation transfer |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2000 |
|
Title: |
Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
|
Title: |
Human to Mouse ISO GO annotation transfer |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Bikorimana JP |
Year: |
2022 |
Journal: |
iScience |
Title: |
The CIt protocol: A blueprint to potentiate the immunogenicity of immunoproteasome-reprogrammed mesenchymal stromal cells. |
Volume: |
25 |
Issue: |
12 |
Pages: |
105537 |
|
•
•
•
•
•
|
Pathway |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
19 |
Description: |
Phosphothreonine; by MLCK, CIT and ROCK2 |
Type: |
modified residue |
End: |
19 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
333
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
334
|
Fragment?: |
false |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
603
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2055
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1674
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
193
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
196
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Ehrenberg AE |
Year: |
2020 |
Journal: |
Clin Exp Allergy |
Title: |
Characterization of a 7 kDa pollen allergen belonging to the gibberellin-regulated protein family from three Cupressaceae species. |
Volume: |
50 |
Issue: |
8 |
Pages: |
964-972 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tuppo L |
Year: |
2013 |
Journal: |
Clin Exp Allergy |
Title: |
Peamaclein--a new peach allergenic protein: similarities, differences and misleading features compared to Pru p 3. |
Volume: |
43 |
Issue: |
1 |
Pages: |
128-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Inomata N |
Year: |
2020 |
Journal: |
Allergol Int |
Title: |
Gibberellin-regulated protein allergy: Clinical features and cross-reactivity. |
Volume: |
69 |
Issue: |
1 |
Pages: |
11-18 |
|
•
•
•
•
•
|
Publication |
First Author: |
Berrocal-Lobo M |
Year: |
2002 |
Journal: |
Plant Physiol |
Title: |
Snakin-2, an antimicrobial peptide from potato whose gene is locally induced by wounding and responds to pathogen infection. |
Volume: |
128 |
Issue: |
3 |
Pages: |
951-61 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This is the GASA gibberellin regulated cysteine rich protein (GRPs) family. The expression of these proteins is up-regulated by the plant hormone gibberellin, most of these proteins have a role in plant development and some of its members have antimicrobial activity [, ]. There are 12 cysteine residues conserved within the alignment giving the potential for these proteins to possess 6 disulphide bonds.Included in this family are some GRPs found in fruits and pollens that have been identified as allergens, including peach Pru p 7, Japanese apricot Pru m 7, orange Cit s 7, pomegranate Pun g 7, and cypress pollen GRP [, , ]. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
724
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Bornstein MR |
Year: |
2023 |
Journal: |
Cell Metab |
Title: |
Comprehensive quantification of metabolic flux during acute cold stress in mice. |
Volume: |
35 |
Issue: |
11 |
Pages: |
2077-2092.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li X |
Year: |
2022 |
Journal: |
Aging Cell |
Title: |
Cap-independent translation of GPLD1 enhances markers of brain health in long-lived mutant and drug-treated mice. |
Volume: |
21 |
Issue: |
9 |
Pages: |
e13685 |
|
•
•
•
•
•
|
Publication |
First Author: |
Senkevitch E |
Year: |
2012 |
Journal: |
Mol Genet Metab |
Title: |
A novel biochemically salvageable animal model of hyperammonemia devoid of N-acetylglutamate synthase. |
Volume: |
106 |
Issue: |
2 |
Pages: |
160-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun S |
Year: |
2021 |
Journal: |
Cell Death Dis |
Title: |
Neutrophil extracellular traps impair intestinal barrier functions in sepsis by regulating TLR9-mediated endoplasmic reticulum stress pathway. |
Volume: |
12 |
Issue: |
6 |
Pages: |
606 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vissers YL |
Year: |
2004 |
Journal: |
Am J Physiol Gastrointest Liver Physiol |
Title: |
NOS2 deficiency increases intestinal metabolism both in nonstimulated and endotoxemic mice. |
Volume: |
286 |
Issue: |
5 |
Pages: |
G747-51 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
193
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Loewen SK |
Year: |
1999 |
Journal: |
J Biol Chem |
Title: |
Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2. |
Volume: |
274 |
Issue: |
35 |
Pages: |
24475-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Izquierdo E |
Year: |
2022 |
Journal: |
Blood |
Title: |
Extracellular vesicles and PD-L1 suppress macrophages, inducing therapy resistance in TP53-deficient B-cell malignancies. |
Volume: |
139 |
Issue: |
25 |
Pages: |
3617-3629 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li MX |
Year: |
1999 |
Journal: |
Biochim Biophys Acta |
Title: |
Aberrations of ammonia metabolism in ornithine carbamoyltransferase-deficient spf-ash mice and their prevention by treatment with urea cycle intermediate amino acids and an ornithine aminotransferase inactivator. |
Volume: |
1455 |
Issue: |
1 |
Pages: |
1-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Markovics A |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
Immune Recognition of Citrullinated Proteoglycan Aggrecan Epitopes in Mice with Proteoglycan-Induced Arthritis and in Patients with Rheumatoid Arthritis. |
Volume: |
11 |
Issue: |
7 |
Pages: |
e0160284 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mackey JR |
Year: |
1998 |
Journal: |
Cancer Res |
Title: |
Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines. |
Volume: |
58 |
Issue: |
19 |
Pages: |
4349-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Granados JZ |
Year: |
2020 |
Journal: |
PLoS One |
Title: |
Activated whole-body arginine pathway in high-active mice. |
Volume: |
15 |
Issue: |
6 |
Pages: |
e0235095 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meyer M |
Year: |
1997 |
Journal: |
J Mol Biol |
Title: |
In vitro binding of the response regulator CitB and of its carboxy-terminal domain to A + T-rich DNA target sequences in the control region of the divergent citC and citS operons of Klebsiella pneumoniae. |
Volume: |
269 |
Issue: |
5 |
Pages: |
719-31 |
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•
•
•
•
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Publication |
First Author: |
Ingmer H |
Year: |
1998 |
Journal: |
Mol Microbiol |
Title: |
Destabilized inheritance of pSC101 and other Escherichia coli plasmids by DpiA, a novel two-component system regulator. |
Volume: |
29 |
Issue: |
1 |
Pages: |
49-59 |
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•
•
•
•
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Publication |
First Author: |
Wintjens R |
Year: |
1996 |
Journal: |
J Mol Biol |
Title: |
Structural classification of HTH DNA-binding domains and protein-DNA interaction modes. |
Volume: |
262 |
Issue: |
2 |
Pages: |
294-313 |
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•
•
•
•
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Publication |
First Author: |
Müller CW |
Year: |
2001 |
Journal: |
Curr Opin Struct Biol |
Title: |
Transcription factors: global and detailed views. |
Volume: |
11 |
Issue: |
1 |
Pages: |
26-32 |
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•
•
•
•
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Publication |
First Author: |
Bott M |
Year: |
1997 |
Journal: |
Arch Microbiol |
Title: |
Anaerobic citrate metabolism and its regulation in enterobacteria. |
Volume: |
167 |
Issue: |
2-3 |
Pages: |
78-88 |
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•
•
•
•
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Protein Domain |
Type: |
Family |
Description: |
Members of this group are response regulators containing CheY-like receiver and HTH (helix-turn-helix) DNA-binding domains. Several members of this group have been characterised as response regulators controlling the genes involved in metabolism of citrate or C4-dicarboxylates (aspartate, fumarate, malate, and succinate). In Klebsiella pneumoniae, the phosphorylation of CitB, subsequent conformational changes and increase of apparent DNA-binding affinity (10 to 100-fold), and specific binding to the two sites in the citC-citS intergenic region have been shown experimentally []. The DcuS/R system in Escherichia coli is involved in C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system []. The DpiB/A system (synonyms: CriR, CitB, but note that the name CitB can also be used for unrelated proteins) is involved in transcriptional regulation of the cit operon (citrate-specific fermentation genes) and of genes involved in plasmid inheritance [].Response regulators of the microbial two-component signal transduction systems typically consist of an N-terminal CheY-like receiver domain and a C-terminal output (usually DNA-binding) domain [, ]. In response to an environmental stimulus, a phosphoryl group is transferred from the His residue of sensor histidine kinase to an Asp residue in the CheY-like receiver domain of the cognate response regulator. Phosphorylation of the CheY-like receiver domain induces conformational changes that activate an associated output domain. Phosphorylation-induced conformational changes in the response regulator molecule have been demonstrated in direct structural studies []. In members of this group, these conformational changes affect the binding of the associated HTH domains to their recognition sites on the chromosomal DNA.HTH domains are very diverse with respect to their sequence, as well as the specific binding sites that they recognise [, , ]. There have been several attempts to classify them [, ]. A detailed sequence analysis of response regulator proteins has been hampered by the remarkable sequence conservation of their N-terminal CheY-like receiver domain, which largely masked (dis)similarities of the DNA-binding domains of various response regulators.For additional information please see [, ]. |
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
192
|
Fragment?: |
false |
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•
•
•
|
Publication |
First Author: |
Galsgaard KD |
Year: |
2020 |
Journal: |
Am J Physiol Gastrointest Liver Physiol |
Title: |
Glucagon receptor signaling is not required for N-carbamoyl glutamate- and l-citrulline-induced ureagenesis in mice. |
Volume: |
318 |
Issue: |
5 |
Pages: |
G912-G927 |
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•
•
•
•
•
|
Publication |
First Author: |
Zientz E |
Year: |
1998 |
Journal: |
J Bacteriol |
Title: |
Fumarate regulation of gene expression in Escherichia coli by the DcuSR (dcuSR genes) two-component regulatory system. |
Volume: |
180 |
Issue: |
20 |
Pages: |
5421-5 |
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•
•
•
•
•
|
Publication |
First Author: |
Lewis RJ |
Year: |
2002 |
Journal: |
J Mol Biol |
Title: |
Dimer formation and transcription activation in the sporulation response regulator Spo0A. |
Volume: |
316 |
Issue: |
2 |
Pages: |
235-45 |
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•
•
•
•
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Publication |
First Author: |
Volz K |
Year: |
1993 |
Journal: |
Biochemistry |
Title: |
Structural conservation in the CheY superfamily. |
Volume: |
32 |
Issue: |
44 |
Pages: |
11741-53 |
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•
•
•
•
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Publication |
First Author: |
Stock AM |
Year: |
2000 |
Journal: |
Annu Rev Biochem |
Title: |
Two-component signal transduction. |
Volume: |
69 |
|
Pages: |
183-215 |
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•
•
•
•
|
Publication |
First Author: |
West AH |
Year: |
2001 |
Journal: |
Trends Biochem Sci |
Title: |
Histidine kinases and response regulator proteins in two-component signaling systems. |
Volume: |
26 |
Issue: |
6 |
Pages: |
369-76 |
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