This entry contains proteins with a C-terminal MOFRL (multi-organism fragment with rich Leucine) domain. Proteins with this domain frequently possess an N-terminal MOFRL-associated domain. The functions of these domains are not known. Proteins with these domains include:Glycerate kinase (GLYCTK; EC 2.7.1.31), which phosphorylates D-glycerate to generate 3-phospho-D-glycerate. D-glyceric aciduria, which can lead to mental retardation or microcephaly, results frommutations in the GLYCTK gene [, ].Glycerate 2-kinase (GCK; EC 2.7.1.165), with a similar function but generates 2-phospho-D-glycerate, is found in archaea []and the thermophilic bacterium Thermotoga maritima[].Uncharacterized protein C13B9.2 from the nematode Caenorhabditis elegans.
