Type |
Details |
Score |
Publication |
First Author: |
Helmbrecht MS |
Year: |
2015 |
Journal: |
Dev Biol |
Title: |
Loss of Npn1 from motor neurons causes postnatal deficits independent from Sema3A signaling. |
Volume: |
399 |
Issue: |
1 |
Pages: |
2-14 |
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•
•
•
•
•
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Publication |
First Author: |
Cyr AR |
Year: |
2013 |
Journal: |
Redox Biol |
Title: |
Maintenance of mitochondrial genomic integrity in the absence of manganese superoxide dismutase in mouse liver hepatocytes. |
Volume: |
1 |
|
Pages: |
172-7 |
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•
•
•
•
•
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Publication |
First Author: |
Kan HE |
Year: |
2004 |
Journal: |
J Physiol |
Title: |
Phosphorylated guanidinoacetate partly compensates for the lack of phosphocreatine in skeletal muscle of mice lacking guanidinoacetate methyltransferase. |
Volume: |
560 |
Issue: |
Pt 1 |
Pages: |
219-29 |
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•
•
•
•
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Publication |
First Author: |
Morales PE |
Year: |
2021 |
Journal: |
FASEB J |
Title: |
Skeletal muscle type-specific mitochondrial adaptation to high-fat diet relies on differential autophagy modulation. |
Volume: |
35 |
Issue: |
10 |
Pages: |
e21933 |
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•
•
•
•
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Publication |
First Author: |
Zimmermann S |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
Induction of suppressor of cytokine signaling-1 by Toxoplasma gondii contributes to immune evasion in macrophages by blocking IFN-gamma signaling. |
Volume: |
176 |
Issue: |
3 |
Pages: |
1840-7 |
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•
•
•
•
•
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Publication |
First Author: |
He H |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Parental and sexual conflicts over the Peg3 imprinted domain. |
Volume: |
6 |
|
Pages: |
38136 |
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•
•
•
•
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Publication |
First Author: |
Becker C |
Year: |
2018 |
Journal: |
EMBO Rep |
Title: |
CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis. |
Volume: |
19 |
Issue: |
5 |
|
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•
•
•
•
•
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Publication |
First Author: |
Zechel S |
Year: |
2006 |
Journal: |
Eur J Neurosci |
Title: |
FGF-2 deficiency does not alter vulnerability of the dopaminergic nigrostriatal system towards MPTP intoxication in mice. |
Volume: |
23 |
Issue: |
6 |
Pages: |
1671-5 |
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•
•
•
•
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Publication |
First Author: |
Zmuda EJ |
Year: |
2010 |
Journal: |
Mol Endocrinol |
Title: |
The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction. |
Volume: |
24 |
Issue: |
7 |
Pages: |
1423-33 |
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•
•
•
•
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Publication |
First Author: |
Takahashi N |
Year: |
1999 |
Journal: |
J Exp Med |
Title: |
Leptin is an endogenous protective protein against the toxicity exerted by tumor necrosis factor. |
Volume: |
189 |
Issue: |
1 |
Pages: |
207-12 |
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•
•
•
•
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Publication |
First Author: |
Bailly-Maitre B |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance. |
Volume: |
285 |
Issue: |
9 |
Pages: |
6198-207 |
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•
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•
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Publication |
First Author: |
Foryst-Ludwig A |
Year: |
2015 |
Journal: |
J Biol Chem |
Title: |
Adipose Tissue Lipolysis Promotes Exercise-induced Cardiac Hypertrophy Involving the Lipokine C16:1n7-Palmitoleate. |
Volume: |
290 |
Issue: |
39 |
Pages: |
23603-15 |
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•
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Publication |
First Author: |
Fischbach MA |
Year: |
2006 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2. |
Volume: |
103 |
Issue: |
44 |
Pages: |
16502-7 |
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Publication |
First Author: |
Chabory E |
Year: |
2009 |
Journal: |
J Clin Invest |
Title: |
Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice. |
Volume: |
119 |
Issue: |
7 |
Pages: |
2074-85 |
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•
•
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Publication |
First Author: |
Solopov PA |
Year: |
2022 |
Journal: |
Am J Pathol |
Title: |
Alcohol Increases Lung Angiotensin-Converting Enzyme 2 Expression and Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Subunit 1-Induced Acute Lung Injury in K18-hACE2 Transgenic Mice. |
Volume: |
192 |
Issue: |
7 |
Pages: |
990-1000 |
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•
•
•
•
•
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Publication |
First Author: |
Zerlanko BJ |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Premature senescence and increased TGFβ signaling in the absence of Tgif1. |
Volume: |
7 |
Issue: |
4 |
Pages: |
e35460 |
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•
•
•
•
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Publication |
First Author: |
Hiramatsu N |
Year: |
2015 |
Journal: |
Am J Pathol |
Title: |
Multiple Mechanisms of Unfolded Protein Response-Induced Cell Death. |
Volume: |
185 |
Issue: |
7 |
Pages: |
1800-8 |
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Publication |
First Author: |
Abdelwahid E |
Year: |
2004 |
Journal: |
Pediatr Res |
Title: |
Cellular disorganization and extensive apoptosis in the developing heart of mice that lack cardiac muscle alpha-actin: apparent cause of perinatal death. |
Volume: |
55 |
Issue: |
2 |
Pages: |
197-204 |
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•
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Publication |
First Author: |
Paolini A |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
Attenuation of autophagy impacts on muscle fibre development, starvation induced stress and fibre regeneration following acute injury. |
Volume: |
8 |
Issue: |
1 |
Pages: |
9062 |
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Publication |
First Author: |
Berrabah W |
Year: |
2014 |
Journal: |
Hepatology |
Title: |
Glucose sensing O-GlcNAcylation pathway regulates the nuclear bile acid receptor farnesoid X receptor (FXR). |
Volume: |
59 |
Issue: |
5 |
Pages: |
2022-33 |
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Publication |
First Author: |
Kawano T |
Year: |
2023 |
Journal: |
Cell Rep |
Title: |
ER proteostasis regulators cell-non-autonomously control sleep. |
Volume: |
42 |
Issue: |
3 |
Pages: |
112267 |
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Publication |
First Author: |
Tocchetti CG |
Year: |
2012 |
Journal: |
Diabetes |
Title: |
GSH or palmitate preserves mitochondrial energetic/redox balance, preventing mechanical dysfunction in metabolically challenged myocytes/hearts from type 2 diabetic mice. |
Volume: |
61 |
Issue: |
12 |
Pages: |
3094-105 |
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•
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Publication |
First Author: |
Wagner KV |
Year: |
2011 |
Journal: |
Psychoneuroendocrinology |
Title: |
Pituitary glucocorticoid receptor deletion reduces vulnerability to chronic stress. |
Volume: |
36 |
Issue: |
4 |
Pages: |
579-87 |
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Publication |
First Author: |
Cartwright IM |
Year: |
2021 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Mucosal acidosis elicits a unique molecular signature in epithelia and intestinal tissue mediated by GPR31-induced CREB phosphorylation. |
Volume: |
118 |
Issue: |
20 |
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Publication |
First Author: |
Rossner MJ |
Year: |
2008 |
Journal: |
PLoS One |
Title: |
Disturbed clockwork resetting in Sharp-1 and Sharp-2 single and double mutant mice. |
Volume: |
3 |
Issue: |
7 |
Pages: |
e2762 |
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Publication |
First Author: |
Latt HM |
Year: |
2018 |
Journal: |
Neuroscience |
Title: |
Oxytocin Inhibits Corticosterone-induced Apoptosis in Primary Hippocampal Neurons. |
Volume: |
379 |
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Pages: |
383-389 |
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Publication |
First Author: |
Stein TD |
Year: |
2002 |
Journal: |
J Neurosci |
Title: |
Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways. |
Volume: |
22 |
Issue: |
17 |
Pages: |
7380-8 |
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Publication |
First Author: |
Ducreux S |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Inverse regulation of the cytosolic Ca²⁺ buffer parvalbumin and mitochondrial volume in muscle cells via SIRT1/PGC-1α axis. |
Volume: |
7 |
Issue: |
9 |
Pages: |
e44837 |
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Publication |
First Author: |
Prell T |
Year: |
2012 |
Journal: |
Eur J Neurosci |
Title: |
The unfolded protein response in models of human mutant G93A amyotrophic lateral sclerosis. |
Volume: |
35 |
Issue: |
5 |
Pages: |
652-60 |
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Publication |
First Author: |
Schroen B |
Year: |
2004 |
Journal: |
Circ Res |
Title: |
Thrombospondin-2 is essential for myocardial matrix integrity: increased expression identifies failure-prone cardiac hypertrophy. |
Volume: |
95 |
Issue: |
5 |
Pages: |
515-22 |
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First Author: |
Vogel J |
Year: |
2003 |
Journal: |
Blood |
Title: |
Transgenic mice overexpressing erythropoietin adapt to excessive erythrocytosis by regulating blood viscosity. |
Volume: |
102 |
Issue: |
6 |
Pages: |
2278-84 |
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First Author: |
Soliz J |
Year: |
2007 |
Journal: |
Am J Physiol Regul Integr Comp Physiol |
Title: |
Acute and chronic exposure to hypoxia alters ventilatory pattern but not minute ventilation of mice overexpressing erythropoietin. |
Volume: |
293 |
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R1702-10 |
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First Author: |
Kim D |
Year: |
2001 |
Journal: |
Cell Immunol |
Title: |
Relationships between IFNgamma, IL-6, corticosterone, and Listeria monocytogenes pathogenesis in BALB/c mice. |
Volume: |
207 |
Issue: |
1 |
Pages: |
13-8 |
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Year: |
1992 |
Journal: |
Int J Neurosci |
Title: |
Strain variation in immune response and behavior following the death of cage cohorts. |
Volume: |
65 |
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First Author: |
Venkatraman JT |
Year: |
1994 |
Journal: |
Biochim Biophys Acta |
Title: |
Genotype effects on the antioxidant enzymes activity and mRNA expression in liver and kidney tissues of autoimmune-prone MRL/MpJ-lpr/lpr mice. |
Volume: |
1213 |
Issue: |
2 |
Pages: |
167-75 |
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First Author: |
Jareborg N |
Year: |
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Journal: |
Genome Res |
Title: |
Comparative analysis of noncoding regions of 77 orthologous mouse and human gene pairs. |
Volume: |
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First Author: |
Potten CS |
Year: |
2002 |
Journal: |
Cell Prolif |
Title: |
Cell kinetic studies in the murine ventral tongue epithelium: the effects of repeated exposure to keratinocyte growth factor. |
Volume: |
35 Suppl 1 |
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22-31 |
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First Author: |
Huang P |
Year: |
2006 |
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Exp Eye Res |
Title: |
Synergism between phospholipase D2 and sorbitol accumulation in diabetic cataract formation through modulation of Na,K-ATPase activity and osmotic stress. |
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Am J Physiol Regul Integr Comp Physiol |
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Sex-dependent regulation of hypoxic ventilation in mice and humans is mediated by erythropoietin. |
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Proc Natl Acad Sci U S A |
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Molecular components of signal amplification in olfactory sensory cilia. |
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Year: |
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Gene Expr Patterns |
Title: |
Unfolded Protein Response (UPR) is activated during normal lens development. |
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First Author: |
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Year: |
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Nucleic Acids Res |
Title: |
Intrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/β-catenin target gene expression. |
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Year: |
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Am J Physiol Renal Physiol |
Title: |
Dietary salt intake modulates differential splicing of the Na-K-2Cl cotransporter NKCC2. |
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Year: |
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Proc Natl Acad Sci U S A |
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Interferon induction of IFITM proteins promotes infection by human coronavirus OC43. |
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First Author: |
Kong YX |
Year: |
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Journal: |
Aging Cell |
Title: |
Increase in mitochondrial DNA mutations impairs retinal function and renders the retina vulnerable to injury. |
Volume: |
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Year: |
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Lab Invest |
Title: |
The roles of oxidative stress, endoplasmic reticulum stress, and autophagy in aldosterone/mineralocorticoid receptor-induced podocyte injury. |
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Proc Natl Acad Sci U S A |
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High expression levels of macrophage migration inhibitory factor sustain the innate immune responses of neonates. |
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First Author: |
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Year: |
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PLoS Pathog |
Title: |
The frustrated host response to Legionella pneumophila is bypassed by MyD88-dependent translation of pro-inflammatory cytokines. |
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Year: |
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Journal: |
Hum Mol Genet |
Title: |
Activating the unfolded protein response in osteocytes causes hyperostosis consistent with craniodiaphyseal dysplasia. |
Volume: |
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Year: |
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Sci Rep |
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Social rank-associated stress vulnerability predisposes individuals to cocaine attraction. |
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Year: |
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Pancreatic lipase-related protein 2 is responsible for the increased hepatic retinyl ester hydrolase activity in vitamin A-deficient mice. |
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Year: |
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Neurobiol Stress |
Title: |
Forebrain overexpression of type 1 adenylyl cyclase promotes molecular stability and behavioral resilience to physical stress. |
Volume: |
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Year: |
2021 |
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Mamm Genome |
Title: |
Alternative exon splicing and differential expression in pancreatic islets reveals candidate genes and pathways implicated in early diabetes development. |
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Year: |
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Journal: |
J Invest Dermatol |
Title: |
TRPC3 Antagonizes Pruritus in a Mouse Contact Dermatitis Model. |
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Magimaidas A |
Year: |
2016 |
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Oncotarget |
Title: |
Gadd45b deficiency promotes premature senescence and skin aging. |
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Year: |
2023 |
Journal: |
Bone |
Title: |
HIF-1α mediates osteoclast-induced disuse osteoporosis via cytoophidia in the femur of mice. |
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Year: |
2022 |
Journal: |
Biochem J |
Title: |
Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells. |
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479 |
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Year: |
2023 |
Journal: |
Hum Mol Genet |
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Insights into energy balance dysregulation from a mouse model of methylmalonic aciduria. |
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First Author: |
Barber J |
Year: |
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Journal: |
Curr Opin Struct Biol |
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Photosystem II: a multisubunit membrane protein that oxidises water. |
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Bork P |
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Journal: |
FASEB J |
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A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. |
Volume: |
11 |
Issue: |
1 |
Pages: |
68-76 |
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•
•
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Protein Domain |
Type: |
Homologous_superfamily |
Description: |
Oxygenic photosynthesis uses two multi-subunit photosystems (I and II) located in the cell membranes of cyanobacteria and in the thylakoid membranes of chloroplasts in plants and algae. Photosystem II (PSII) has a P680 reaction centre containing chlorophyll 'a' that uses light energy to carry out the oxidation (splitting) of water molecules, and to produce ATP via a proton pump. Photosystem I (PSI) has a P700 reaction centre containing chlorophyll that takes the electron and associated hydrogen donated from PSII to reduce NADP+ to NADPH. Both ATP and NADPH are subsequently used in the light-independent reactions to convert carbon dioxide to glucose using the hydrogen atom extracted from water by PSII, releasing oxygen as a by-product.PSII is a multisubunit protein-pigment complex containing polypeptides both intrinsic and extrinsic to the photosynthetic membrane [, , ]. Within the core of the complex, the chlorophyll and beta-carotene pigments are mainly bound to the antenna proteins CP43 (PsbC) and CP47 (PsbB), which pass the excitation energy on to the reaction centre proteins D1 (Qb, PsbA) and D2 (Qa, PsbD) that bind all the redox-active cofactors involved in the energy conversion process. The PSII oxygen-evolving complex (OEC) oxidises water to provide protons for use by PSI, and consists of OEE1 (PsbO), OEE2 (PsbP) and OEE3 (PsbQ). The remaining subunits in PSII are of low molecular weight (less than 10kDa), and are involved in PSII assembly, stabilisation, dimerisation, and photo-protection []. This entry represents the intrinsic antenna proteins CP43 (PsbC) and CP47 (PsbB) found in the reaction centre of PSII. These polypeptides bind to chlorophyll a and beta-carotene and pass the excitation energy on to the reaction centre []. This entry also includes the iron-stress induced chlorophyll-binding protein CP43' (IsiA), which evolved in cyanobacteria from a PSII protein to cope with light limitations and stress conditions. Under iron-deficient growth conditions, CP43' associates with PSI to form a complex that consists of a ring of 18 or more CP43' molecules around a PSI trimer, which significantly increases the light-harvesting system of PSI. IsiA can also provide photoprotection for PSII []. |
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Protein Domain |
Type: |
Family |
Description: |
Oxygenic photosynthesis uses two multi-subunit photosystems (I and II) located in the cell membranes of cyanobacteria and in the thylakoid membranes of chloroplasts in plants and algae. Photosystem II (PSII) has a P680 reaction centre containing chlorophyll 'a' that uses light energy to carry out the oxidation (splitting) of water molecules, and to produce ATP via a proton pump. Photosystem I (PSI) has a P700 reaction centre containing chlorophyll that takes the electron and associated hydrogen donated from PSII to reduce NADP+ to NADPH. Both ATP and NADPH are subsequently used in the light-independent reactions to convert carbon dioxide to glucose using the hydrogen atom extracted from water by PSII, releasing oxygen as a by-product.PSII is a multisubunit protein-pigment complex containing polypeptides both intrinsic and extrinsic to the photosynthetic membrane [, , ]. Within the core of the complex, the chlorophyll and beta-carotene pigments are mainly bound to the antenna proteins CP43 (PsbC) and CP47 (PsbB), which pass the excitation energy on to the reaction centre proteins D1 (Qb, PsbA) and D2 (Qa, PsbD) that bind all the redox-active cofactors involved in the energy conversion process. The PSII oxygen-evolving complex (OEC) oxidises water to provide protons for use by PSI, and consists of OEE1 (PsbO), OEE2 (PsbP) and OEE3 (PsbQ). The remaining subunits in PSII are of low molecular weight (less than 10kDa), and are involved in PSII assembly, stabilisation, dimerisation, and photo-protection []. This entry represents the intrinsic antenna proteins CP43 (PsbC) and CP47 (PsbB) found in the reaction centre of PSII. These polypeptides bind to chlorophyll a and beta-carotene and pass the excitation energy on to the reaction centre []. This entry also includes the iron-stress induced chlorophyll-binding protein CP43' (IsiA), which evolved in cyanobacteria from a PSII protein to cope with light limitations and stress conditions. Under iron-deficient growth conditions, CP43' associates with PSI to form a complex that consists of a ring of 18 or more CP43' molecules around a PSI trimer, which significantly increases the light-harvesting system of PSI. IsiA can also provide photoprotection for PSII []. |
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2004 |
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J Pathol |
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J Neurosci |
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Cebula M |
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PLoS One |
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Russell AL |
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2018 |
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Endocrinology |
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Krízková A |
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Behav Brain Res |
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2011 |
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Neuroscience |
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Mol Immunol |
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2022 |
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Mol Neurobiol |
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Bhat GK |
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2003 |
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Biol Reprod |
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Does leptin mediate the effect of photoperiod on immune function in mice? |
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69 |
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2016 |
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J Neurosci |
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2021 |
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Circulation |
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144 |
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18 |
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1500-1515 |
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Publication |
First Author: |
Althaus FR |
Year: |
1987 |
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Mol Biol Biochem Biophys |
Title: |
ADP-ribosylation of proteins. Enzymology and biological significance. |
Volume: |
37 |
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Publication |
First Author: |
Anantharaman V |
Year: |
2003 |
Journal: |
Genome Biol |
Title: |
New connections in the prokaryotic toxin-antitoxin network: relationship with the eukaryotic nonsense-mediated RNA decay system. |
Volume: |
4 |
Issue: |
12 |
Pages: |
R81 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1013
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1014
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
973
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Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1014
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1014
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1014
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1014
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Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1014
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Fragment?: |
false |
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Publication |
First Author: |
Smith SB |
Year: |
1995 |
Journal: |
Mouse Genome |
Title: |
Slow progressive loss of photoreceptor cells in vitiligo mice co-segregates with gradual depigmentation of the pelage |
Volume: |
93 |
Issue: |
3 |
Pages: |
871-3 |
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Publication |
First Author: |
Kamiya N |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Crystal structure of oxygen-evolving photosystem II from Thermosynechococcus vulcanus at 3.7-A resolution. |
Volume: |
100 |
Issue: |
1 |
Pages: |
98-103 |
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Publication |
First Author: |
Shi LX |
Year: |
2004 |
Journal: |
Biochim Biophys Acta |
Title: |
The low molecular mass subunits of the photosynthetic supracomplex, photosystem II. |
Volume: |
1608 |
Issue: |
2-3 |
Pages: |
75-96 |
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Publication |
First Author: |
Raymond J |
Year: |
2004 |
Journal: |
Biochim Biophys Acta |
Title: |
The evolutionary development of the protein complement of photosystem 2. |
Volume: |
1655 |
Issue: |
1-3 |
Pages: |
133-9 |
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Publication |
First Author: |
Nakajima Y |
Year: |
2018 |
Journal: |
J Biol Chem |
Title: |
Thylakoid membrane lipid sulfoquinovosyl-diacylglycerol (SQDG) is required for full functioning of photosystem II in Thermosynechococcus elongatus. |
Volume: |
293 |
Issue: |
38 |
Pages: |
14786-14797 |
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