RNF141, also known as zinc finger protein 230 (ZNF230), is a RING finger protein present primarily in the nuclei of spermatogonia, the acrosome, and the tail of spermatozoa []. It may have a broad function during early development of vertebrates. It plays an important role in spermatogenesis, including spermatogenic cell proliferation and sperm maturation, as well as motility and fertilization []. It also exhibits DNA binding activity [, ]. RNF141 corresponding ZNF230 gene mutation may be associated with azoospermia []. RNF141 contains a C3HC4-type RING finger domain that may function as an activator module in transcription [].
