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Search results 1 to 3 out of 3 for Ctnnb1

Category restricted to ProteinDomain (x)

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Categories

Category: ProteinDomain
Type Details Score
Protein Domain
Type: Domain
Description: This region tends to appear at the N terminus of proteins also containing DNA-binding HMG (high mobility group) boxes () and appears to bind the armadillo repeat of CTNNB1 (beta-catenin), forming a stable complex. Signalling by Wnt through TCF/LCF is involved in developmental patterning, induction of neural tissues, cell fate decisions and stem cell differentiation []. Isoforms of HMG T-cell factors lacking the N-terminal CTNNB1-binding domain cannot fulfil their role as transcriptional activators in T-cell differentiation [, ].
Protein Domain
Type: Family
Description: Adenomatous polyposis coli protein 2 (APC2) promotes rapid degradation of CTNNB1 (beta-catenin) and may function as a tumor suppressor. It may function in Wnt signaling [, , ].
Protein Domain
Type: Domain
Description: This entry represents the RNA recognition motif (RRM) of G3BP1, which has been identified as a phosphorylation-dependent endoribonuclease that interacts with the SH3 domain of RasGAP []. However, this interaction has been questioned []. G3BP1 binds to and cleaves the 3'-untranslated region (3'-UTR) of the c-myc mRNA in a phosphorylation-dependent manner []. G3BP1 has been linked to the formation of stress granules (SGs), membrane-less structures consisting of mRNA and protein aggregates form rapidly in response to a wide range of stresses and viral infections [, ]. G3BP1 is targeted by many viruses and may be involved in innate immune response [, ]. Its activities can be regulated through post-translational modifications [].It has also been shown that G3BP1 is a novel Dishevelled-associated protein that is methylated upon Wnt3a stimulation and that arginine methylation of G3BP1 regulates both Ctnnb1 mRNA and canonical Wnt/beta-catenin signaling []. Furthermore, G3BP1 can be associated with the 3'-UTR of beta-F1 mRNA in cytoplasmic RNA-granules, demonstrating that G3BP1 may specifically repress the translation of the transcript [].G3BP1 contains an N-terminal nuclear transfer factor 2 (NTF2)-like domain, an RNA recognition motif (RRM domain), and an Arg-Gly-rich region (RGG-rich region, or arginine methylation motif). The RRM domain and RGG-rich region are canonically associated with RNA binding [].