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Search results 201 to 300 out of 315 for Vps13a

0.037s
Type Details Score
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1914628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876153
Specimen Label: UC Davis_1876153
Detected: true
Specimen Num: 32
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1920928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876156
Specimen Label: UC Davis_1876156
Detected: true
Specimen Num: 35
GXD Expression  
Probe: MGI:4424984
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829239
Age: embryonic day 14.5
Image: euxassay_012729_01
Specimen Label: euxassay_012729_01
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4424984
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829239
Age: embryonic day 14.5
Image: euxassay_012729_02
Specimen Label: euxassay_012729_02
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4424984
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829239
Age: embryonic day 14.5
Image: euxassay_012729_03
Specimen Label: euxassay_012729_03
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4424984
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829239
Age: embryonic day 14.5
Image: euxassay_012729_04
Specimen Label: euxassay_012729_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4424984
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829239
Age: embryonic day 14.5
Image: euxassay_012729_05
Specimen Label: euxassay_012729_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4424984
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829239
Age: embryonic day 14.5
Image: euxassay_012729_06
Specimen Label: euxassay_012729_06
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:4424984
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829239
Age: embryonic day 14.5
Image: euxassay_012729_07
Specimen Label: euxassay_012729_07
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:4424984
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829239
Age: embryonic day 14.5
Image: euxassay_012729_08
Specimen Label: euxassay_012729_08
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:4424984
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829239
Age: embryonic day 14.5
Image: euxassay_012729_09
Specimen Label: euxassay_012729_09
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:4424984
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829239
Age: embryonic day 14.5
Image: euxassay_012729_10
Specimen Label: euxassay_012729_10
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:4424984
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829239
Age: embryonic day 14.5
Image: euxassay_012729_11
Specimen Label: euxassay_012729_11
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:4424984
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829239
Age: embryonic day 14.5
Image: euxassay_012729_12
Specimen Label: euxassay_012729_12
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:4424984
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829239
Age: embryonic day 14.5
Image: euxassay_012729_13
Specimen Label: euxassay_012729_13
Detected: true
Specimen Num: 13
GXD Expression  
Probe: MGI:4424984
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829239
Age: embryonic day 14.5
Image: euxassay_012729_14
Specimen Label: euxassay_012729_14
Detected: true
Specimen Num: 14
GXD Expression  
Probe: MGI:4424984
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829239
Age: embryonic day 14.5
Image: euxassay_012729_15
Specimen Label: euxassay_012729_15
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:4424984
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829239
Age: embryonic day 14.5
Image: euxassay_012729_16
Specimen Label: euxassay_012729_16
Detected: true
Specimen Num: 16
GXD Expression  
Probe: MGI:4424984
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829239
Age: embryonic day 14.5
Image: euxassay_012729_17
Specimen Label: euxassay_012729_17
Detected: true
Specimen Num: 17
GXD Expression  
Probe: MGI:4424984
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829239
Age: embryonic day 14.5
Image: euxassay_012729_18
Specimen Label: euxassay_012729_18
Detected: true
Specimen Num: 18
GXD Expression  
Probe: MGI:4424984
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829239
Age: embryonic day 14.5
Image: euxassay_012729_19
Specimen Label: euxassay_012729_19
Detected: true
Specimen Num: 19
GXD Expression  
Probe: MGI:4424984
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829239
Age: embryonic day 14.5
Image: euxassay_012729_20
Specimen Label: euxassay_012729_20
Detected: true
Specimen Num: 20
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1893928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876174
Specimen Label: UC Davis_1876174
Detected: true
Specimen Num: 6
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1893928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876175
Specimen Label: UC Davis_1876175
Detected: true
Specimen Num: 7
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1893928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876149
Specimen Label: UC Davis_1876149
Detected: true
Specimen Num: 28
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1893928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876150
Specimen Label: UC Davis_1876150
Detected: true
Specimen Num: 29
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1898628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876185
Specimen Label: UC Davis_1876185
Detected: true
Specimen Num: 16
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1718528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876179
Specimen Label: UC Davis_1876179
Detected: true
Specimen Num: 11
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1866628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876172
Specimen Label: UC Davis_1876172
Detected: true
Specimen Num: 4
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1866628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876147
Specimen Label: UC Davis_1876147
Detected: true
Specimen Num: 26
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1918028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876167
Note: vesicular gland
Specimen Label: UC Davis_1876167
Detected: true
Specimen Num: 45
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1918028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876168
Note: vesicular gland
Specimen Label: UC Davis_1876168
Detected: true
Specimen Num: 46
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1750328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876177
Specimen Label: UC Davis_1876177
Detected: true
Specimen Num: 9
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876160
Specimen Label: UC Davis_1876160
Detected: true
Specimen Num: 39
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1832128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876186
Specimen Label: UC Davis_1876186
Detected: true
Specimen Num: 17
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1832128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876187
Specimen Label: UC Davis_1876187
Detected: true
Specimen Num: 18
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1832128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876188
Specimen Label: UC Davis_1876188
Detected: true
Specimen Num: 19
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1832128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876159
Specimen Label: UC Davis_1876159
Detected: true
Specimen Num: 38
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1702128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876170
Specimen Label: UC Davis_1876170
Detected: true
Specimen Num: 2
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1702128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876171
Specimen Label: UC Davis_1876171
Detected: true
Specimen Num: 3
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1702128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876144
Specimen Label: UC Davis_1876144
Detected: true
Specimen Num: 23
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1702128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876145
Specimen Label: UC Davis_1876145
Detected: true
Specimen Num: 24
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1702128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876146
Specimen Label: UC Davis_1876146
Detected: true
Specimen Num: 25
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1929028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876161
Specimen Label: UC Davis_1876161
Detected: true
Specimen Num: 40
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1929028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876162
Specimen Label: UC Davis_1876162
Detected: true
Specimen Num: 41
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3276428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876173
Specimen Label: UC Davis_1876173
Detected: true
Specimen Num: 5
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3276428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876148
Specimen Label: UC Davis_1876148
Detected: true
Specimen Num: 27
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3281228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876169
Specimen Label: UC Davis_1876169
Detected: true
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3281228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876142
Specimen Label: UC Davis_1876142
Detected: true
Specimen Num: 21
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:2991528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876184
Specimen Label: UC Davis_1876184
Detected: true
Specimen Num: 15
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1868228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6690982
Age: postnatal adult
Image: UC Davis_1876163
Specimen Label: UC Davis_1876163
Detected: true
Specimen Num: 42
Protein
Organism: Mus musculus/domesticus
Length: 580  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 647  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 449  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 676  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 638  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 3993  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1457  
Fragment?: false
Publication
First Author: Suzuki J
Year: 2013
Journal: Science
Title: Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells.
Volume: 341
Issue: 6144
Pages: 403-6
Publication
First Author: Kim GW
Year: 2017
Journal: FEBS J
Title: Xk-related protein 8 regulates myoblast differentiation and survival.
Volume: 284
Issue: 21
Pages: 3575-3588
Protein
Organism: Mus musculus/domesticus
Length: 401  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 510  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 510  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1510  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1429  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 177  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 921  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 857  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 771  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: false
Publication
First Author: Brickner JH
Year: 1997
Journal: J Cell Biol
Title: SOI1 encodes a novel, conserved protein that promotes TGN-endosomal cycling of Kex2p and other membrane proteins by modulating the function of two TGN localization signals.
Volume: 139
Issue: 1
Pages: 23-36
Publication
First Author: Park JS
Year: 2012
Journal: J Cell Sci
Title: VPS13 regulates membrane morphogenesis during sporulation in Saccharomyces cerevisiae.
Volume: 125
Issue: Pt 12
Pages: 3004-11
Publication
First Author: Chen S
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Vps13 is required for the packaging of the ER into autophagosomes during ER-phagy.
Volume: 117
Issue: 31
Pages: 18530-18539
Publication
First Author: Ho M
Year: 1994
Journal: Cell
Title: Isolation of the gene for McLeod syndrome that encodes a novel membrane transport protein.
Volume: 77
Issue: 6
Pages: 869-80
Publication
First Author: Khamlichi S
Year: 1995
Journal: Eur J Biochem
Title: Purification and partial characterization of the erythrocyte Kx protein deficient in McLeod patients.
Volume: 228
Issue: 3
Pages: 931-4
Publication
First Author: Park JS
Year: 2020
Journal: Mol Biol Cell
Title: XK is a partner for VPS13A: a molecular link between Chorea-Acanthocytosis and McLeod Syndrome.
Volume: 31
Issue: 22
Pages: 2425-2436
Publication
First Author: Valverde DP
Year: 2019
Journal: J Cell Biol
Title: ATG2 transports lipids to promote autophagosome biogenesis.
Volume: 218
Issue: 6
Pages: 1787-1798
Protein Domain
Type: Family
Description: This family is represented by the multipass membrane protein XK, which may be involved in sodium-dependent transport of neutral amino acids or oligopeptides. It forms a heterodimer with Kell. In humans, Kell is an 93kDa type II membrane glycoprotein with endothelin-3-converting enzyme activity that is linked by a single disulphide bond to XK, that spans the membrane ten times. An absence of XK leads to clinical symptoms termed the McLeod syndrome , an X-linked multi-system disorder characterised by late onset abnormalities in the neuromuscular and hematopoietic systems [, ]. It has been shown that XK recruits the lipid transfer protein VPS13A from lipid droplets to the endoplasmic reticulum (ER) membrane and dysregulation of a VPS13A-XK complex is the common basis for Chorea-Acanthocytosis and McLeod Syndrome []. The human and mouse Xk-related (Xkr) families consist of nine and eight members, respectively, and mutations or variations in the gene of Xkr members are associated to human diseases. Xkr8 and other members of the family promote phosphatidylserine exposure in apoptotic cells [, , ].
Protein Domain
Type: Domain
Description: This domain lies towards the N terminus, just downstream from . This domain is involved in lipid binding and transport [, , ]. This domain specifically interacts with phosphatidic acid and phosphorylated forms of phosphatidyl inositol [].VPS13 proteins have been implicated in processes including vesicle fusion, autophagy, and actin regulation. They bind phospholipids and act as channels that mediate the transfer of lipids between membranes at organelle contact sites [, , ]. It has been proposed that members of this entry have the capacity to bind and likely transfer tens of glycerolipids at once. Yeast VPS13 acts at multiple cellular sites, namely the interface between mitochondria and the vacuole, on endosomes, on the nuclear-vacuole junction and the vacuole, depending on the carbon source and metabolic state. Most evidence showed that mammalian VPS13A, VPS13C and VPS13D localize at contacts between the ER and other organelles, i.e. VPS13A and VPS13D bridge the ER to mitochondria, VPS13C bridges the ER to late endosomes and lysosomes and VPS13B may localize to endosome-endosome contacts [, , ]. Mutations in human VPS13 proteins (VPS13A-D) cause different diseases such as Chorea-acanthocytosis, Cohen syndrome, Parkinson's disease, and spastic ataxia, respectively which suggests they have different functions [, ].
Protein Domain
Type: Domain
Description: This entry represents the repeating region of VPS13. This repeating region shares a common core element that includes a well-conserved P-X4-P-X13-17-G sequence [, ]. This region contains a FFAT motif which mediates VAMP binding and tethering of the ER.VPS13 proteins have been implicated in processes including vesicle fusion, autophagy, and actin regulation. They bind phospholipids and act as channels that mediate the transfer of lipids between membranes at organelle contact sites [, , ]. It has been proposed that members of this entry have the capacity to bind and likely transfer tens of glycerolipids at once. Yeast VPS13 acts at multiple cellular sites, namely the interface between mitochondria and the vacuole, on endosomes, on the nuclear-vacuole junction and the vacuole, depending on the carbon source and metabolic state. Most evidence showed that mammalian VPS13A, VPS13C and VPS13D localize at contacts between the ER and other organelles, i.e. VPS13A and VPS13D bridge the ER to mitochondria, VPS13C bridges the ER to late endosomes and lysosomes and VPS13B may localize to endosome-endosome contacts [, , ]. Mutations in human VPS13 proteins (VPS13A-D) cause different diseases such as Chorea-acanthocytosis, Cohen syndrome, Parkinson's disease, and spastic ataxia, respectively which suggests they have different functions [, ].
Protein Domain
Type: Domain
Description: This is the N-terminal chorein domain of VPS13 and ATG2 proteins, which is highly conserved. ATG2 proteins are involved in autophagosome assembly, playing a key role in nonvesicular lipid transfer [, , , ]. This domain has a scoop shape whose concave surface is lined by hydrophobic residues which bind glycerophospholipids.VPS13 proteins have been implicated in processes including vesicle fusion, autophagy, and actin regulation. They bind phospholipids and act as channels that mediate the transfer of lipids between membranes at organelle contact sites [, , ]. It has been proposed that members of this entry have the capacity to bind and likely transfer tens of glycerolipids at once. Yeast VPS13 acts at multiple cellular sites, namely the interface between mitochondria and the vacuole, on endosomes, on the nuclear-vacuole junction and the vacuole, depending on the carbon source and metabolic state. Most evidence showed that mammalian VPS13A, VPS13C and VPS13D localize at contacts between the ER and other organelles, i.e. VPS13A and VPS13D bridge the ER to mitochondria, VPS13C bridges the ER to late endosomes and lysosomes and VPS13B may localize to endosome-endosome contacts [, , ]. Mutations in human VPS13 proteins (VPS13A-D) cause different diseases such as Chorea-acanthocytosis, Cohen syndrome, Parkinson's disease, and spastic ataxia, respectively which suggests they have different functions [, ].
Protein
Organism: Mus musculus/domesticus
Length: 3748  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 3748  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 4359  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 4390  
Fragment?: false
Publication  
First Author: Kolakowski D
Year: 2021
Journal: Int J Mol Sci
Title: The GTPase Arf1 Is a Determinant of Yeast Vps13 Localization to the Golgi Apparatus.
Volume: 22
Issue: 22
Protein
Organism: Mus musculus/domesticus
Length: 2339  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 3211  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 46  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1918  
Fragment?: true
Publication
First Author: Koizumi K
Year: 2013
Journal: Development
Title: Identification of SHRUBBY, a SHORT-ROOT and SCARECROW interacting protein that controls root growth and radial patterning.
Volume: 140
Issue: 6
Pages: 1292-300
Publication
First Author: De M
Year: 2017
Journal: J Cell Biol
Title: The Vps13p-Cdc31p complex is directly required for TGN late endosome transport and TGN homotypic fusion.
Volume: 216
Issue: 2
Pages: 425-439