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Search results 201 to 300 out of 390 for Fancd2

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Type Details Score
Gene
Type: gene
Organism: macaque, rhesus
Publication
First Author: Yang Y
Year: 2015
Journal: Nucleic Acids Res
Title: FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress.
Volume: 43
Issue: 17
Pages: 8325-39
Allele
Name: Fancd2 opposite strand; targeted mutation 1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Allele
Name: Fancd2 opposite strand; targeted mutation 2e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele
Name: Fancd2 opposite strand; targeted mutation 2a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
Publication
First Author: Takahashi Y
Year: 1999
Journal: J Exp Med
Title: Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice.
Volume: 190
Issue: 3
Pages: 399-410
Publication
First Author: Sato K
Year: 2012
Journal: Nucleic Acids Res
Title: DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI.
Volume: 40
Issue: 10
Pages: 4553-61
Publication
First Author: Wilson JB
Year: 2008
Journal: Oncogene
Title: FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3.
Volume: 27
Issue: 26
Pages: 3641-52
Allele  
Name: Fancd2 opposite strand; gene trap IST13579D2, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Strain
Attribute String: mutant strain, coisogenic, targeted mutation
Strain
Attribute String: coisogenic, mutant strain, targeted mutation
Allele  
Name: Fancd2 opposite strand; gene trap IST14023H12, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Interaction Experiment
Description: Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability.
Interaction Experiment
Description: Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
Interaction Experiment
Description: mTOR regulates DNA damage response through NF-B-mediated FANCD2 pathway in hematopoietic cells.
Interaction Experiment
Description: Fancd2 is required for nuclear retention of Foxo3a in hematopoietic stem cell maintenance.
Publication
First Author: Yuan F
Year: 2009
Journal: J Biol Chem
Title: FANCI protein binds to DNA and interacts with FANCD2 to recognize branched structures.
Volume: 284
Issue: 36
Pages: 24443-52
Publication
First Author: Seki S
Year: 2007
Journal: Genes Cells
Title: A requirement of FancL and FancD2 monoubiquitination in DNA repair.
Volume: 12
Issue: 3
Pages: 299-310
Publication
First Author: Marek LR
Year: 2006
Journal: DNA Repair (Amst)
Title: Drosophila homologs of FANCD2 and FANCL function in DNA repair.
Volume: 5
Issue: 11
Pages: 1317-26
Allele
Name: Fanconi anemia, complementation group D2; endonuclease-mediated mutation 1, Tingting Zhang
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: Fanconi anemia, complementation group D2; targeted mutation 1, Scott Houghtaling
Allele Type: Targeted
Attribute String: Null/knockout
Interaction Experiment
Description: CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage.
Genotype
Symbol: Fancd2/Fancd2
Background: B6.129S4-Fancd2
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Fancd2/Fancd2
Background: 129S4/SvJae-Fancd2
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Fancd2/Fancd2
Background: involves: 129S4/SvJae * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Fancd2/Fancd2 Usp1/Usp1
Background: involves: 129S5/SvEvBrd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Aldh2/Aldh2 Fancd2/Fancd2
Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Fancd2/Fancd2
Background: C57BL/6-Fancd2
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Alpi A
Year: 2007
Journal: Mol Cell Biol
Title: UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination.
Volume: 27
Issue: 24
Pages: 8421-30
Publication
First Author: Smogorzewska A
Year: 2007
Journal: Cell
Title: Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.
Volume: 129
Issue: 2
Pages: 289-301
Publication
First Author: Singh TR
Year: 2009
Journal: Blood
Title: Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M.
Volume: 114
Issue: 1
Pages: 174-80
GXD Expression  
Probe: MGI:6694992
Assay Type: Immunohistochemistry
Annotation Date: 2023-11-01
Strength: Present
Sex: Female
Emaps: EMAPS:1657819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:7544998
Age: embryonic day 11.5
Note: Co-localized staining of Fancd2 was shown. The proportion of Fancd2 positive cells was significantly decreased compared with the wild-type (quantified in Fig 7B).
Specimen Label: 7A E11.5 -/-
Detected: true
Specimen Num: 26
GXD Expression  
Probe: MGI:6694992
Assay Type: Immunohistochemistry
Annotation Date: 2023-11-01
Strength: Present
Sex: Female
Emaps: EMAPS:1657820
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:7544998
Age: embryonic day 12.5
Note: Co-localized staining of Fancd2 was shown. The proportion of Fancd2 positive cells was significantly decreased compared with the wild-type (quantified in Fig 7B).
Specimen Label: 7A E12.5 -/-
Detected: true
Specimen Num: 28
GO Term
Publication
First Author: Ciccia A
Year: 2007
Journal: Mol Cell
Title: Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM.
Volume: 25
Issue: 3
Pages: 331-43
Publication
First Author: Kato Y
Year: 2015
Journal: Hum Mol Genet
Title: FANCB is essential in the male germline and regulates H3K9 methylation on the sex chromosomes during meiosis.
Volume: 24
Issue: 18
Pages: 5234-49
Publication
First Author: Meetei AR
Year: 2003
Journal: Nat Genet
Title: A novel ubiquitin ligase is deficient in Fanconi anemia.
Volume: 35
Issue: 2
Pages: 165-70
Protein
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: false
Protein Domain
Type: Family
Description: Fanconi anemia (FA) is a human disorder characterized by cancer susceptibility and cellular sensitivity to DNA crosslinks and other damages. This entry represents FANCG, which is part of the FA core complex required for the monoubiquitylation of FANCD2 and the FANCI heterodimer. The FA complex coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination []. Besides being part of the FA complex, FANCG also promotes formation of a protein complex containing BRCA2, FANCD2 and XRCC3 [].
Protein Domain
Type: Domain
Description: This entry represents the second of three UBC-like domains found in the FANCL protein, which is the catalytic E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia). Eight subunits encoded by the Fanconi anaemia gene products form a multisubunit nuclear complex which is required for mono-ubiquitination of a downstream FA protein, FANCD2 [, ].
Protein Domain
Type: Domain
Description: This entry represents the third of three UBC-like domains found in the FANCL protein, which is the catalytic E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia). Eight subunits encoded by the Fanconi anaemia gene products form a multisubunit nuclear complex which is required for mono-ubiquitination of a downstream FA protein, FANCD2 [].
Protein
Organism: Mus musculus/domesticus
Length: 1330  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: false
Publication
First Author: Hodson C
Year: 2011
Journal: J Biol Chem
Title: Structural analysis of human FANCL, the E3 ligase in the Fanconi anemia pathway.
Volume: 286
Issue: 37
Pages: 32628-37
Protein Domain
Type: Family
Description: Fanconi anemia-associated protein of 24kDa (FAAP24) plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. It regulates FANCD2 monoubiquitination upon DNA damage. When repressed, it induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents. It targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA [].Fanconi anemia (FA) is a human disorder characterized by cancer susceptibility and cellular sensitivity to DNA crosslinks and other damages. The FA complex repairs the interstrand cross-linking (ICL) lesions and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination. It is required for the monoubiquitylation of FANCD2 and FANCI heterodimer. The FA core complex consists of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FANCT (UBET2), FAAP100 and FAAP24 [, ].
Protein Domain
Type: Domain
Description: Fanconi Anaemia (FA) is a cancer predisposition disorder characterised by chromosome fragility and hypersensitivity to genotoxic agents that suggest defects in the molecular mechanisms of DNA damage signalling and repair. In response to DNA damage, the FA core complex monoubiquitinates the FANCD2 protein. This ubiquitination targets FANCD2 to nuclear foci where it interacts with a variety of DNA repair proteins.The FA group E protein (FANCE) has an important role in DNA repair, functioning as the FANCD2-binding protein in the FA core complex []. This entry represents the C-terminal domain of FANCE, which consists predominantly of helices and does not contain any β-strands. This domain folds in a continuous right-handed solenoidal pattern from its N terminus to its C terminus.
Protein
Organism: Mus musculus/domesticus
Length: 591  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 660  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 169  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 229  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 412  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 43  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 73  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 558  
Fragment?: false
Protein Domain
Type: Family
Description: Fanconi anemia (FA) is a human disorder characterized by cancer susceptibility and cellular sensitivity to DNA crosslinks and other damages. The FA complex repairs the interstrand cross-linking (ICL) lesions and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination. It is required for the monoubiquitylation of FANCD2 and FANCI heterodimer. The FA core complex consists of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FANCT (UBET2), FAAP100 and FAAP24 [, ].This entry represents FANCC [].
Protein Domain
Type: Domain
Description: FANCI and FANCD2 form a complex central to the Fanconi anemia (FA) pathway, which is essential for the repair of DNA interstrand cross-links. FANCI has four distinct alpha solenoid (α-α superhelical) segments (S1-S4). Two mostly helical segments intervene between solenoids 1 and 2 (HD1), and between solenoids 2 and 3 (HD2) [].This entry represents the solenoid 1 cap (S1-cap) domain of the Fanconi anemia complementation group I protein (FANCI).
Protein Domain
Type: Domain
Description: FANCI and FANCD2 form a complex central to the Fanconi anemia (FA) pathway, which is essential for the repair of DNA interstrand cross-links. FANCI has four distinct alpha solenoid (α-α superhelical) segments (S1-S4). Two mostly helical segments intervene between solenoids 1 and 2 (HD1), and between solenoids 2 and 3 (HD2) [].This is the solenoid 1 (S1) domain of the Fanconi anemia group I protein (FANCI).
Protein Domain
Type: Domain
Description: FANCI and FANCD2 form a complex central to the Fanconi anemia (FA) pathway, which is essential for the repair of DNA interstrand cross-links. FANCI has four distinct alpha solenoid (α-α superhelical) segments (S1-S4). Two mostly helical segments intervene between solenoids 1 and 2 (HD1), and between solenoids 2 and 3 (HD2) [].This is the helical domain 1 (HD1) of the Fanconi anemia complementation group I protein (FANCI).
Protein Domain
Type: Domain
Description: FANCI and FANCD2 form a complex central to the Fanconi anemia (FA) pathway, which is essential for the repair of DNA interstrand cross-links. FANCI has four distinct alpha solenoid (α-α superhelical) segments (S1-S4). Two mostly helical segments intervene between solenoids 1 and 2 (HD1), and between solenoids 2 and 3 (HD2) [].This is the helical domain 2 (HD2) of the Fanconi anemia complementation group I protein (FANCI).
Protein Domain
Type: Domain
Description: FANCI and FANCD2 form a complex central to the Fanconi anemia (FA) pathway, which is essential for the repair of DNA interstrand cross-links. FANCI has four distinct alpha solenoid (α-α superhelical) segments (S1-S4). Two mostly helical segments intervene between solenoids 1 and 2 (HD1), and between solenoids 2 and 3 (HD2) [].This is the solenoid 3 (S3) domain of the Fanconi anemia group I protein (FANCI).
Protein Domain
Type: Domain
Description: FANCI and FANCD2 form a complex central to the Fanconi anemia (FA) pathway, which is essential for the repair of DNA interstrand cross-links. FANCI has four distinct alpha solenoid (α-α superhelical) segments (S1-S4). Two mostly helical segments intervene between solenoids 1 and 2 (HD1), and between solenoids 2 and 3 (HD2) [].This is the solenoid 4 (S4) domain of the Fanconi anemia group I protein (FANCI).
Protein Domain
Type: Domain
Description: FANCI and FANCD2 form a complex central to the Fanconi anemia (FA) pathway, which is essential for the repair of DNA interstrand cross-links. FANCI has four distinct alpha solenoid (α-α superhelical) segments (S1-S4). Two mostly helical segments intervene between solenoids 1 and 2 (HD1), and between solenoids 2 and 3 (HD2) [].This is the solenoid 2 (S2) domain of the Fanconi anemia group I protein (FANCI).
Protein Domain
Type: Family
Description: Fanconi anemia (FA) is a human disorder characterized by cancer susceptibility and cellular sensitivity to DNA crosslinks and other damages. The FA complex repairs the interstrand cross-linking (ICL) lesions and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination. It is required for the monoubiquitylation of FANCD2 and FANCI heterodimer. The FA core complex consists of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FANCT (UBET2), FAAP100 and FAAP24 [, ].This entry represents FANCA [].
Protein
Organism: Mus musculus/domesticus
Length: 384  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 462  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 71  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 484  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 151  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 406  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 412  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 526  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 355  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 171  
Fragment?: false
Publication
First Author: Nookala RK
Year: 2007
Journal: Nucleic Acids Res
Title: Insights into Fanconi Anaemia from the structure of human FANCE.
Volume: 35
Issue: 5
Pages: 1638-48
Publication
First Author: Joo W
Year: 2011
Journal: Science
Title: Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway.
Volume: 333
Issue: 6040
Pages: 312-6