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Search results 1001 to 1100 out of 1161 for E2f1

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Type Details Score
Publication
12244100 | -
First Author: Piluso D
Year: 2002
Journal: J Biol Chem
Title: Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1.
Volume: 277
Issue: 48
Pages: 46799-808
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Publication
10920196 | -
First Author: Vogel JL
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Autocatalytic proteolysis of the transcription factor-coactivator C1 (HCF): a potential role for proteolytic regulation of coactivator function.
Volume: 97
Issue: 17
Pages: 9425-30
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Publication
16624878 | -
First Author: Vogel JL
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Site-specific proteolysis of the transcriptional coactivator HCF-1 can regulate its interaction with protein cofactors.
Volume: 103
Issue: 18
Pages: 6817-22
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Publication
31049581 | -
First Author: Gudkova D
Year: 2019
Journal: Nucleic Acids Res
Title: HCF-2 inhibits cell proliferation and activates differentiation-gene expression programs.
Volume: 47
Issue: 11
Pages: 5792-5808
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Publication
19153467 | -
First Author: Kulathila R
Year: 2009
Journal: Acta Crystallogr D Biol Crystallogr
Title: The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9.
Volume: 65
Issue: Pt 1
Pages: 58-66
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Publication
22021857 | -
First Author: Dueber EC
Year: 2011
Journal: Science
Title: Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination.
Volume: 334
Issue: 6054
Pages: 376-80
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Publication
21447281 | -
First Author: Damgaard RB
Year: 2011
Journal: Discov Med
Title: Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity.
Volume: 11
Issue: 58
Pages: 221-31
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Publication
12609738 | -
First Author: Izeta A
Year: 2003
Journal: Gene
Title: Primary structure and compartmentalization of Drosophila melanogaster host cell factor.
Volume: 305
Issue: 2
Pages: 175-83
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Publication
2568582 | -
First Author: Sabina RL
Year: 1989
Journal: Mol Cell Biol
Title: Expression of three stage-specific transcripts of AMP deaminase during myogenesis.
Volume: 9
Issue: 5
Pages: 2244-6
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Protein Domain
IPR043536 | HCF1/2
Type: Family
Description: This entry includes Host cell factor 1 (HCF1) and Host cell factor 2 (HCF2) from humans. They contain an N-terminal kelch domain and a C-terminal FnIII domain. However, HCF2 is smaller than HCF-1, lacking the complete central region including the HCF1 specific repeats and as a result is not subject to proteolytic processing []. This entry also includes their Drosophila melanogaster homologue, dHCF, which is involved in both activation and repression of transcription during fly development []. Host cell factor homologue hcf-1 from C. elegans controls the cell cycle through mitotic histone phosphorylation modulation and negatively regulates responses to environmental stresses [].HCF1 is associated with the activation and repression of gene expression. It is brought to specific promoters by association with DNA-sequence-specific transcription factors such as Sp1, GABP, YY1, Ronin/THAP11, and E2F1 and E2F4 []. HCFC1 recruits and is a part of several different complexes, including the SET1 histone methyltransferase complex (transcription activation), the SIN3 histone deacetylase complex (transcription repression) [], the THAP1/THAP3-HCFC1-OGT complex (required for the regulation of the transcriptional activity of RRM1) [], and the NSL complex (acetylation of nucleosomal histone H4) [].HCF2 is involved in activation of differentiation and morphogenesis gene expression programs, and in parallel in inhibition of cellular growth and metabolism [].
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Protein Domain
IPR037854 | HCF1
Type: Family
Description: Host cell factor 1 (HCFC1) is associated with the activation and repression of gene expression. It is brought to specific promoters by association with DNA-sequence-specific transcription factors such as Sp1, GABP, YY1, Ronin/THAP11, and E2F1 and E2F4 []. HCFC1 recruits and is a part of several different complexes, including the SET1 histone methyltransferase complex (transcription activation), the SIN3 histone deacetylase complex (transcription repression) [], the THAP1/THAP3-HCFC1-OGT complex (required for the regulation of the transcriptional activity of RRM1) [], and the NSL complex (acetylation of nucleosomal histone H4) []. This entry includes mammalian HCFC1 and the Drosophila homologue, dHCF. They undergo a process of proteolytic maturation to produce a heterodimeric complex of HCF-N and HCF-C subunits, by different enzymes, O-GlcNAc transferase and taspase1, respectively [, ]. They share a Kelch domain, regions biased for basic (Basic) or acidic (Acidic) amino acids, fibronectin type 3 repeats, and a nuclear localization signal [].During human herpes simplex virus infection, HCFC1 forms a multiprotein-DNA complex enabling transcription of the virus's early genes []. It is also a co-activator of EGR2/Krox20 []and the GA-binding protein GABP2 [], and represses ZBTB17/Miz-1 [].
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Protein Domain
IPR041933 | BIRC2/BIRC3_UBA
Type: Domain
Description: The entry represents the UBA domain found in c-IAPs, including BIRC2 (also known as C-IAP1) and BIRC3 (also known as C-IAP2). c-IAPs function as ubiquitin E3 ligases that mediate the ubiquitination of the substrates involved in apoptosis, nuclear factor-kappaB (NF-kappaB) signaling, and oncogenesis [, ]. Unlike other apoptosis proteins such as XIAP, c-IAPs exhibit minimal binding to caspases and may not play an important role in the inhibition of these proteases. c-IAP1 is a potent regulator of the tumor necrosis factor (TNF) receptor family and NF-kappaB signaling pathways in the cytoplasm. It can also regulate E2F1 transcription factor-mediated control of cyclin transcription in the nucleus []. c-IAP2 also influences ubiquitin-dependent pathways that modulate innate immune signalling by activation of NF-kappaB []. c-IAPs contain three N-terminal baculoviral IAP repeat (BIR) domains that enable interactions with proteins, a ubiquitin-association (UBA) domain that is responsible for the binding of polyubiquitin (polyUb), a caspase activation and recruitment domain (CARD) that serves as a protein interaction surface, and a RING domain at the carboxyl terminus that is required for ubiquitin ligase activity [, ].
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Protein Domain
IPR040221 | CDCA7/CDA7L
Type: Family
Description: This entry includes CDCA7 and CDA7L.Cell division cycle-associated protein 7 (CDCA7/JPO1) is a transcription regulator whose expression is activated by c-Myc and by E2F1 []. CDCA7 can associate with Myc in a phosphorylation-dependent manner. CDCA7 phosphorylation by AKT leads to loss of its association with Myc []. This interaction affects Myc-dependent apoptosis and transformation [, , ]. CDCA7 has also been identified as a Notch target involved in hematopoietic stem cell emergence [].Cell division cycle-associated 7-like protein (CDCA7L/JPO2/R1) is closely related to CDCA7/JPO1; and like CDCA7, it plays a role in transcriptional regulation and interacts with c-Myc []. JPO2 overexpression induces metastasis in medulloblastoma []. JPO2 can interact directly and dynamically with chromatin, the dynamics of JPO2 chromatin binding being decelerated upon interaction with LEDGF/p75, which binds and tethers JPO2 to chromatin [, ].JPO2 inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter []. JPO2 and MAOA act upstream of cyclin D1 and E2F1, and are involved in apoptotic signalling pathways [].
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Publication
18194653 | J:131292
First Author: Li J
Year: 2008
Journal: Dev Cell
Title: Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development.
Volume: 14
Issue: 1
Pages: 62-75
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Publication
11350120 | J:69581
First Author: Wang A
Year: 2001
Journal: Genomics
Title: Molecular cloning and characterization of a novel mouse epidermal differentiation gene and its promoter.
Volume: 73
Issue: 3
Pages: 284-90
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Publication
15563841 | J:94137
First Author: Evrard C
Year: 2004
Journal: Gene
Title: Functional analysis of the NPDC-1 gene.
Volume: 343
Issue: 1
Pages: 153-63
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Publication
23443259 | J:207261
 
First Author: Hou ST
Year: 2013
Journal: Sci Rep
Title: Collapsin response mediator protein 3 deacetylates histone H4 to mediate nuclear condensation and neuronal death.
Volume: 3
Pages: 1350
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Publication
19249677 | J:145939
First Author: Ianari A
Year: 2009
Journal: Cancer Cell
Title: Proapoptotic function of the retinoblastoma tumor suppressor protein.
Volume: 15
Issue: 3
Pages: 184-94
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Publication
16213226 | J:129675
First Author: Abella A
Year: 2005
Journal: Cell Metab
Title: Cdk4 promotes adipogenesis through PPARgamma activation.
Volume: 2
Issue: 4
Pages: 239-49
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Publication
24728959 | J:211181
First Author: Federico A
Year: 2014
Journal: Biol Open
Title: Hmga1/Hmga2 double knock-out mice display a "superpygmy" phenotype.
Volume: 3
Issue: 5
Pages: 372-8
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Publication
32968066 | J:303351
First Author: Oh J
Year: 2020
Journal: Nat Commun
Title: Macrophage secretion of miR-106b-5p causes renin-dependent hypertension.
Volume: 11
Issue: 1
Pages: 4798
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Publication
12588846 | J:81580
First Author: Kohn MJ
Year: 2003
Journal: Development
Title: Dp1 is required for extra-embryonic development.
Volume: 130
Issue: 7
Pages: 1295-305
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Publication
27991597 | J:243450
 
First Author: Jablonska B
Year: 2016
Journal: Nat Commun
Title: Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury.
Volume: 7
Pages: 13866
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Publication
29444430 | J:271068
First Author: Böni-Schnetzler M
Year: 2018
Journal: Cell Rep
Title: β Cell-Specific Deletion of the IL-1 Receptor Antagonist Impairs β Cell Proliferation and Insulin Secretion.
Volume: 22
Issue: 7
Pages: 1774-1786
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Publication
26459601 | J:237592
First Author: Zou Z
Year: 2015
Journal: J Cell Biol
Title: mTORC2 promotes cell survival through c-Myc-dependent up-regulation of E2F1.
Volume: 211
Issue: 1
Pages: 105-22
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Publication
28723554 | J:260578
First Author: Murata K
Year: 2017
Journal: Immunity
Title: Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis.
Volume: 47
Issue: 1
Pages: 66-79.e5
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Publication
26724859 | J:232734
First Author: Chen CL
Year: 2016
Journal: Cell Metab
Title: NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism.
Volume: 23
Issue: 1
Pages: 206-19
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Publication
22985930 | J:192757
First Author: Dingar D
Year: 2012
Journal: J Mol Cell Cardiol
Title: Anti-apoptotic function of the E2F transcription factor 4 (E2F4)/p130, a member of retinoblastoma gene family in cardiac myocytes.
Volume: 53
Issue: 6
Pages: 820-8
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Publication
19917728 | J:156401
First Author: Martinez LA
Year: 2010
Journal: Mol Cell Biol
Title: E2F3 is a mediator of DNA damage-induced apoptosis.
Volume: 30
Issue: 2
Pages: 524-36
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Publication
10708476 | J:61215
First Author: Johnson DG
Year: 2000
Journal: Mol Carcinog
Title: The paradox of E2F1: oncogene and tumor suppressor gene.
Volume: 27
Issue: 3
Pages: 151-7
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Publication
9556576 | J:47422
First Author: Gopalkrishnan RV
Year: 1998
Journal: J Biol Chem
Title: The p53 tumor suppressor inhibits transcription of the TATA-less mouse DP1 promoter.
Volume: 273
Issue: 18
Pages: 10972-8
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Publication
16969098 | J:115502
First Author: Fedele M
Year: 2006
Journal: Cell Cycle
Title: Critical role of the HMGA2 gene in pituitary adenomas.
Volume: 5
Issue: 18
Pages: 2045-8
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Publication
22431589 | J:182657
First Author: Suh SS
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: MicroRNAs/TP53 feedback circuitry in glioblastoma multiforme.
Volume: 109
Issue: 14
Pages: 5316-21
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Publication
25284223 | J:215524
First Author: Wei N
Year: 2014
Journal: Mol Cell
Title: Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damage.
Volume: 56
Issue: 2
Pages: 323-32
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Publication
19893569 | J:259107
First Author: Wu ZL
Year: 2010
Journal: Cell Death Differ
Title: Polycomb protein EZH2 regulates E2F1-dependent apoptosis through epigenetically modulating Bim expression.
Volume: 17
Issue: 5
Pages: 801-10
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Publication
31262817 | J:278407
First Author: Wang C
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Long noncoding RNA EMS connects c-Myc to cell cycle control and tumorigenesis.
Volume: 116
Issue: 29
Pages: 14620-14629
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Publication
33462236 | J:300910
First Author: Larrue C
Year: 2021
Journal: Nat Commun
Title: Adrenomedullin-CALCRL axis controls relapse-initiating drug tolerant acute myeloid leukemia cells.
Volume: 12
Issue: 1
Pages: 422
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Publication
12670868 | -
First Author: Wysocka J
Year: 2003
Journal: Genes Dev
Title: Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.
Volume: 17
Issue: 7
Pages: 896-911
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Publication
16829576 | J:111804
First Author: Ou XM
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway.
Volume: 103
Issue: 29
Pages: 10923-8
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Protein
Q922M5
Organism: Mus musculus/domesticus
Length: 438  
Fragment?: false
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Protein
H3BJV7
Organism: Mus musculus/domesticus
Length: 226  
Fragment?: true
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Protein
Q62017
Organism: Mus musculus/domesticus
Length: 187  
Fragment?: true
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Protein
H3BJN2
Organism: Mus musculus/domesticus
Length: 308  
Fragment?: true
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Publication
16360038 | -
First Author: Rubin SM
Year: 2005
Journal: Cell
Title: Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release.
Volume: 123
Issue: 6
Pages: 1093-106
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Publication
15654081 | -
First Author: Chen K
Year: 2005
Journal: J Biol Chem
Title: R1, a novel repressor of the human monoamine oxidase A.
Volume: 280
Issue: 12
Pages: 11552-9
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Publication
27013196 | -
First Author: Chan TS
Year: 2016
Journal: Cancer Res
Title: JPO2/CDCA7L and LEDGF/p75 Are Novel Mediators of PI3K/AKT Signaling and Aggressive Phenotypes in Medulloblastoma.
Volume: 76
Issue: 9
Pages: 2802-12
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Publication
24634210 | -
First Author: Hendrix J
Year: 2014
Journal: J Biol Chem
Title: Dynamics of the ternary complex formed by c-Myc interactor JPO2, transcriptional co-activator LEDGF/p75, and chromatin.
Volume: 289
Issue: 18
Pages: 12494-506
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Publication
16735438 | -
First Author: Maertens GN
Year: 2006
Journal: J Cell Sci
Title: Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin.
Volume: 119
Issue: Pt 12
Pages: 2563-71
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Publication
16616919 | J:111352
First Author: Yoshimoto T
Year: 2006
Journal: Exp Cell Res
Title: The arginine methyltransferase PRMT2 binds RB and regulates E2F function.
Volume: 312
Issue: 11
Pages: 2040-53
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Publication
10915798 | J:63800
First Author: Taniguchi N
Year: 2000
Journal: J Biol Chem
Title: The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm.
Volume: 275
Issue: 41
Pages: 31674-81
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Publication
10965153 | J:74072
First Author: Niinobe M
Year: 2000
Journal: Dev Neurosci
Title: Cellular and subcellular localization of necdin in fetal and adult mouse brain.
Volume: 22
Issue: 4
Pages: 310-9
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Publication
21131441 | J:186820
First Author: Yang IV
Year: 2011
Journal: Am J Respir Cell Mol Biol
Title: Novel regulators of the systemic response to lipopolysaccharide.
Volume: 45
Issue: 2
Pages: 393-402
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Publication
16912189 | J:113386
First Author: Hobbs CA
Year: 2006
Journal: Cancer Res
Title: Tip60 protein isoforms and altered function in skin and tumors that overexpress ornithine decarboxylase.
Volume: 66
Issue: 16
Pages: 8116-22
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Publication
22331469 | J:183798
First Author: Hasegawa N
Year: 2012
Journal: Mol Cell Biol
Title: Mediator subunits MED1 and MED24 cooperatively contribute to pubertal mammary gland development and growth of breast carcinoma cells.
Volume: 32
Issue: 8
Pages: 1483-95
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Publication
18451867 | J:154282
First Author: Nemajerova A
Year: 2008
Journal: Cell Death Differ
Title: Rb function is required for E1A-induced S-phase checkpoint activation.
Volume: 15
Issue: 9
Pages: 1440-9
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Publication
17173070 | J:122861
First Author: Prost S
Year: 2007
Journal: Oncogene
Title: E2F regulates DDB2: consequences for DNA repair in Rb-deficient cells.
Volume: 26
Issue: 24
Pages: 3572-81
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Publication
20080939 | J:158372
First Author: Almeida MQ
Year: 2010
Journal: Hum Mol Genet
Title: Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/- or Rb1+/- backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signaling.
Volume: 19
Issue: 8
Pages: 1387-98
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Publication
11731416 | J:73154
First Author: Guo Z
Year: 2001
Journal: Cancer Res
Title: Inactivation of the retinoblastoma tumor suppressor induces apoptosis protease-activating factor-1 dependent and independent apoptotic pathways during embryogenesis.
Volume: 61
Issue: 23
Pages: 8395-400
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Publication
26743080 | J:246654
First Author: Vattulainen-Collanus S
Year: 2016
Journal: J Cell Sci
Title: Loss of PPARγ in endothelial cells leads to impaired angiogenesis.
Volume: 129
Issue: 4
Pages: 693-705
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Publication
29330298 | J:257880
First Author: Enjoji S
Year: 2018
Journal: Mol Cancer Res
Title: Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis.
Volume: 16
Issue: 3
Pages: 554-563
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Publication
28855541 | J:255811
First Author: Gamper I
Year: 2017
Journal: Sci Rep
Title: Determination of the physiological and pathological roles of E2F3 in adult tissues.
Volume: 7
Issue: 1
Pages: 9932
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Publication
30115652 | J:265931
First Author: Sanchez-Parra C
Year: 2018
Journal: Diabetes
Title: Contribution of the Long Noncoding RNA H19 to β-Cell Mass Expansion in Neonatal and Adult Rodents.
Volume: 67
Issue: 11
Pages: 2254-2267
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Publication
23512667 | J:267246
First Author: Willis MS
Year: 2014
Journal: Cell Biochem Funct
Title: Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1-mediated gene expression in vivo.
Volume: 32
Issue: 1
Pages: 39-50
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Publication
28701484 | J:244849
First Author: Imperatore F
Year: 2017
Journal: EMBO J
Title: SIRT1 regulates macrophage self-renewal.
Volume: 36
Issue: 16
Pages: 2353-2372
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Publication
31862778 | J:285701
First Author: Citron F
Year: 2020
Journal: Cancer Res
Title: Downregulation of miR-223 Expression Is an Early Event during Mammary Transformation and Confers Resistance to CDK4/6 Inhibitors in Luminal Breast Cancer.
Volume: 80
Issue: 5
Pages: 1064-1077
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Publication
23149912 | J:194107
First Author: Lee JH
Year: 2013
Journal: Cancer Res
Title: DNA damage-specific control of cell death by cryptochrome in p53-mutant ras-transformed cells.
Volume: 73
Issue: 2
Pages: 785-91
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Publication
23778138 | J:201425
First Author: Zhu Y
Year: 2013
Journal: J Clin Invest
Title: Dependence receptor UNC5D mediates nerve growth factor depletion-induced neuroblastoma regression.
Volume: 123
Issue: 7
Pages: 2935-47
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Publication
29267372 | J:254690
First Author: Hauck L
Year: 2017
Journal: PLoS One
Title: Cardiac-specific ablation of the E3 ubiquitin ligase Mdm2 leads to oxidative stress, broad mitochondrial deficiency and early death.
Volume: 12
Issue: 12
Pages: e0189861
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Publication
27452520 | J:239255
First Author: Thurlings I
Year: 2017
Journal: Oncogene
Title: Synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer.
Volume: 36
Issue: 6
Pages: 829-839
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Publication
28074012 | J:259463
 
First Author: Gamell C
Year: 2017
Journal: Sci Signal
Title: Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non-small cell lung cancer.
Volume: 10
Issue: 461
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Publication
16340309 | J:107082
First Author: Paulson QX
Year: 2006
Journal: Cell Cycle
Title: E2F3a stimulates proliferation, p53-independent apoptosis and carcinogenesis in a transgenic mouse model.
Volume: 5
Issue: 2
Pages: 184-90
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Publication
25500889 | J:219600
First Author: Hu Z
Year: 2015
Journal: J Clin Invest
Title: TALEN-mediated targeting of HPV oncogenes ameliorates HPV-related cervical malignancy.
Volume: 125
Issue: 1
Pages: 425-36
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Publication
32792525 | J:299732
First Author: Zhou X
Year: 2020
Journal: Nat Commun
Title: Cellular and molecular properties of neural progenitors in the developing mammalian hypothalamus.
Volume: 11
Issue: 1
Pages: 4063
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Publication
27793841 | J:237995
First Author: Kang DW
Year: 2017
Journal: Cancer Res
Title: Phospholipase D1 Acts through Akt/TopBP1 and RB1 to Regulate the E2F1-Dependent Apoptotic Program in Cancer Cells.
Volume: 77
Issue: 1
Pages: 142-152
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Publication
10713672 | J:61095
First Author: Liao DJ
Year: 2000
Journal: Oncogene
Title: Cell cycle basis for the onset and progression of c-Myc-induced, TGFalpha-enhanced mouse mammary gland carcinogenesis.
Volume: 19
Issue: 10
Pages: 1307-17
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Publication
25445542 | J:234218
First Author: Schaefer FM
Year: 2015
Journal: Biochim Biophys Acta
Title: Bone marrow-derived c-jun N-terminal kinase-1 (JNK1) mediates liver regeneration.
Volume: 1852
Issue: 1
Pages: 137-45
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Publication
24971481 | J:230158
First Author: Kim SJ
Year: 2014
Journal: Cell Death Differ
Title: Ablation of galectin-3 induces p27(KIP1)-dependent premature senescence without oncogenic stress.
Volume: 21
Issue: 11
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