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Search results 501 to 527 out of 527 for Acox1

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Type Details Score
Publication
11939592 | J:104835
First Author: Baes M
Year: 2002
Journal: J Neuropathol Exp Neurol
Title: The neuronal migration defect in mice with Zellweger syndrome (Pex5 knockout) is not caused by the inactivity of peroxisomal beta-oxidation.
Volume: 61
Issue: 4
Pages: 368-74
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Publication
34651140 | J:332085
First Author: Ranea-Robles P
Year: 2021
Journal: Kidney360
Title: Peroxisomal L-bifunctional protein (EHHADH) deficiency causes male-specific kidney hypertrophy and proximal tubular injury in mice.
Volume: 2
Issue: 9
Pages: 1441-1454
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Publication
30540494 | J:287917
First Author: Violante S
Year: 2019
Journal: FASEB J
Title: Peroxisomes can oxidize medium- and long-chain fatty acids through a pathway involving ABCD3 and HSD17B4.
Volume: 33
Issue: 3
Pages: 4355-4364
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Genotype
Genotype
Symbol: Ehhadh/Ehhadh Hsd17b4/Hsd17b4
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ehhadh/Ehhadh
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Publication
9525937 | -
First Author: Hayashi H
Year: 1998
Journal: J Biol Chem
Title: Molecular characterization of a glyoxysomal long chain acyl-CoA oxidase that is synthesized as a precursor of higher molecular mass in pumpkin.
Volume: 273
Issue: 14
Pages: 8301-7
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Publication
15581893 | -
First Author: Pedersen L
Year: 2005
Journal: J Mol Biol
Title: Acyl-CoA oxidase 1 from Arabidopsis thaliana. Structure of a key enzyme in plant lipid metabolism.
Volume: 345
Issue: 3
Pages: 487-500
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Publication
29018292 | J:255681
First Author: Arguin G
Year: 2017
Journal: Sci Rep
Title: The loss of P2X7 receptor expression leads to increase intestinal glucose transit and hepatic steatosis.
Volume: 7
Issue: 1
Pages: 12917
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Publication
28594915 | J:245453
First Author: Nakade Y
Year: 2017
Journal: PLoS One
Title: Conophylline inhibits non-alcoholic steatohepatitis in mice.
Volume: 12
Issue: 6
Pages: e0178436
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Publication
25424544 | J:275699
First Author: Yoo HS
Year: 2015
Journal: J Toxicol Environ Health A
Title: Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects.
Volume: 78
Issue: 1
Pages: 15-31
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Protein
D3Z2N6
Organism: Mus musculus/domesticus
Length: 83  
Fragment?: true
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Protein Domain
IPR002655 | Acyl-CoA_oxidase_C
Type: Domain
Description: Acyl-CoA oxidase (ACO) acts on CoA derivatives of fatty acids with chain lengths from 8 to 18. It catalyses the first and rate-determining step of the peroxisomal beta-oxidation of fatty acids [].Acyl-CoA oxidase is a homodimer and the polypeptide chain of the subunit is folded into the N-terminal alpha-domain, beta-domain, and C-terminal alpha-domain []. Functional differences between the peroxisomal acyl-CoA oxidases and the mitochondrial acyl-CoA dehydrogenases are attributed to structural differences in the FAD environments []. Experimental data indicate that, in the pumpkin, the expression patternof ACOX is very similar to that of the glyoxysomal enzyme 3-ketoacyl-CoA thiolase []. In humans, defects in ACOX1 are the cause of pseudoneonatal adrenoleukodystrophy, also known as peroxisomal acyl-CoA oxidase deficiency. Pseudo-NALD is a peroxisomal single-enzyme disorder. Clinical features include mental retardation, leukodystrophy, seizures, mild hepatomegaly and hearing deficit. Pseudo-NALD is characterised by increased plasma levels of very-long chain fatty acids due to a decrease in, or absence of, peroxisome acyl-CoA oxidase activity, despite the peroxisomes being intact and functioning.This entry represents the Acyl-CoA oxidase C-terminal.
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Protein Domain
IPR012258 | Acyl-CoA_oxidase
Type: Family
Description: Acyl-CoA oxidase (ACO) acts on CoA derivatives of fatty acids with chain lengths from 8 to 18. It catalyses the first and rate-determining step of the peroxisomal beta-oxidation of fatty acids and a major producer of hydrogen peroxide (H2O2) [, ].Acyl-CoA oxidase is a homodimer and the polypeptide chain of the subunit is folded into the N-terminal alpha-domain, beta-domain, and C-terminal alpha-domain [, ]. Functional differences between the peroxisomal acyl-CoA oxidases and the mitochondrial acyl-CoA dehydrogenases are attributed to structural differences in the FAD environments []. Experimental data indicate that in the pumpkin, the expression pattern of ACOX is very similar to that of the glyoxysomal enzyme 3-ketoacyl-CoA thiolase []. In humans, defects in ACOX1 are the cause of pseudoneonatal adrenoleukodystrophy, also known as peroxisomal acyl-CoA oxidase deficiency. Clinical features include mental retardation, leukodystrophy, seizures, mild hepatomegaly and hearing deficit. Pseudo-NALD is characterised by increased plasma levels of very-long chain fatty acids due to a decrease in, or absence of, peroxisome acyl-CoA oxidase activity, despite the peroxisomes being intact and functioning [].
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Protein
A0A0J9YVH1
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: true
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Protein
Q9EPL9
Organism: Mus musculus/domesticus
Length: 700  
Fragment?: false
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Protein
Q9DBS4
Organism: Mus musculus/domesticus
Length: 632  
Fragment?: false
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Protein
Q9R0H0
Organism: Mus musculus/domesticus
Length: 661  
Fragment?: false
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Protein
Q9QXD1
Organism: Mus musculus/domesticus
Length: 681  
Fragment?: false
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Protein
Q8C168
Organism: Mus musculus/domesticus
Length: 647  
Fragment?: false
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Protein
Q3UNF3
Organism: Mus musculus/domesticus
Length: 681  
Fragment?: false
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Protein
A2A848
Organism: Mus musculus/domesticus
Length: 625  
Fragment?: true
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Protein
E9Q296
Organism: Mus musculus/domesticus
Length: 685  
Fragment?: false
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Protein
Q3TAW3
Organism: Mus musculus/domesticus
Length: 673  
Fragment?: false
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Protein
Q8C178
Organism: Mus musculus/domesticus
Length: 697  
Fragment?: false
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Publication
11872165 | -
First Author: Nakajima Y
Year: 2002
Journal: J Biochem
Title: Three-dimensional structure of the flavoenzyme acyl-CoA oxidase-II from rat liver, the peroxisomal counterpart of mitochondrial acyl-CoA dehydrogenase.
Volume: 131
Issue: 3
Pages: 365-74
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Protein
E9Q5T5
Organism: Mus musculus/domesticus
Length: 201  
Fragment?: true
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Protein
Q8BW35
Organism: Mus musculus/domesticus
Length: 499  
Fragment?: true
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